Effects of HIV, Cocaine, and Prolonged ART Use on Subclinical Cardiovascular Disease
HIV、可卡因和长期使用 ART 对亚临床心血管疾病的影响
基本信息
- 批准号:9897500
- 负责人:
- 金额:$ 162.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-06-01 至 2023-04-30
- 项目状态:已结题
- 来源:
- 关键词:AIDS/HIV problemAddressAgeAgingAngiographyAnti-Retroviral AgentsAreaAtherosclerosisBaltimoreBasic ScienceBehavioral ResearchBiological MarkersCaliberCardiacCardiovascular DiseasesCardiovascular systemCause of DeathChronicClinicalClinical ResearchCocaineCocaine UsersCohort StudiesCollaborationsCoronaryCoronary ArteriosclerosisCoronary StenosisCreativenessDevelopmentDrug abuseDrug usageElderlyExposure toFosteringFundingFutureGoalsGrantHIVHIV InfectionsHIV antiretroviralHIV therapyHeart DiseasesHomocysteineImpaired cognitionIndividualInfectionInfection preventionInvestigationInvestigator-Initiated ResearchLengthLong-Term EffectsLongitudinal StudiesMarylandMedicalNational Institute of Drug AbuseOutcomeParticipantPharmaceutical PreparationsPopulationResearchResearch PersonnelResearch PriorityResourcesRisk FactorsSubstance Use DisorderSubstance abuse problemTelomere ShorteningTestingTroponin TUnited States National Institutes of Healthantiretroviral therapycocaine usecognitive functioncohortcomorbiditycoronary plaquemiddle agemortalitymultidisciplinaryplatform-independentsuccesstelomereyoung adult
项目摘要
As the age of people living with HIV has been rising steadily due to the success of antiretroviral therapy
(ART), and continued new infections, the number of people with HIV in the US is now 1.2 million and continues
to rise. Since most older adults living with HIV were infected as young adults or in middle age, long-term
effects of HIV and ART are now emerging. HIV/ART-associated comorbidities represent a major challenge for
HIV-infected individuals. Of noninfectious comorbidities, coronary artery disease (CAD) has become one of
leading causes of death among older people with HIV infection. In addition to CAD traditional risk factors, HIV
and ART, cocaine use has been shown to be associated with CAD. In 1999, we received the first NIH grant in
the US to investigate the effects of HIV and cocaine use on subclinical atherosclerosis, specifically HIV-
associated cardiovascular comorbidity. Since then, 4 NIDA-funded studies by this team were conducted and a
cohort of study participants, with/without HIV infection, with/without ART and with/without cocaine use, has
been established and followed in Baltimore, Maryland for 17 consecutive years. Pursuing the goal of examining
the individual and combined effects of HIV infection, long-term exposure to ART, chronic cocaine use, and
other factors on subclinical CAD, we found that cocaine use may induce/accelerate subclinical CAD and other
HIV-associated comorbidities. We recently identified several high priority research questions/hypotheses that
deserve to be explored thorough collaborations with other investigators: (1) coronary plaque volume may be
more sensitive to quantify factors associated with coronary plaque burden, (2) telomere length may be
associated with HIV, cocaine use and aging, (3) Troponin T may be a maker for the degree of coronary plaque
burden, and (4) homocysteine may be a potentially useful biomarker for HIV/cocaine associated comorbidities.
The central objective for this U01 is to further examine whether and how cocaine use influences the HIV/ART-
associated CAD and other comorbidities. The specific aims of this proposed study are: (1) to maintain and
expand our existing cohort involving HIV/ART and cocaine-associated cardiovascular and other comorbidities
as a platform for high priority research and as a platform for other scientific collaborations; (2) to examine
longitudinally the effects of HIV, chronic cocaine use, and prolonged ART exposure on the presence,
development and progression of CCTA-defined subclinical/clinical CAD, (3) to investigate whether cocaine use
exacerbates the HIV-associated decline in cognitive function in HIV-infected cocaine users, (4) to investigate
whether HIV and cocaine are associated with telomere shortening, and (5) to examine interrelationships
between homocysteine (Hcy) and HIV/ART/cocaine-associated comorbidities. All the hypotheses proposed in
this application have not been tested and are crucial to the scientific field of HIV/AIDS and substance abuse.
The proposed study will make unique contributions to a better understanding of whether and how drug abuse
exacerbates cardiovascular and other comorbidities in those with HIV and substance use disorder.
由于抗逆转录病毒疗法的成功,艾滋病毒感染者的年龄一直在稳步上升
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
SHENGHAN LAI其他文献
SHENGHAN LAI的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('SHENGHAN LAI', 18)}}的其他基金
The Impact of Cocaine Abstinence or Reduced Use on Radiomic Features of Noncalcified Coronary Plaques in HIV-Infected Cocaine Users with Silent Coronary Artery Disease
戒断或减少使用可卡因对患有无症状冠状动脉疾病的 HIV 感染可卡因使用者非钙化冠状动脉斑块放射学特征的影响
- 批准号:
9795066 - 财政年份:2019
- 资助金额:
$ 162.13万 - 项目类别:
Effects of HIV, Cocaine, and Prolonged ART Use on Subclinical Cardiovascular Disease
HIV、可卡因和长期使用 ART 对亚临床心血管疾病的影响
- 批准号:
10738836 - 财政年份:2016
- 资助金额:
$ 162.13万 - 项目类别:
Effects of HIV, Cocaine, and Prolonged ART Use on Subclinical Cardiovascular Disease
HIV、可卡因和长期使用 ART 对亚临床心血管疾病的影响
- 批准号:
9428415 - 财政年份:2016
- 资助金额:
$ 162.13万 - 项目类别:
Effects of HIV, Cocaine, and Prolonged ART Use on Subclinical Cardiovascular Disease
HIV、可卡因和长期使用 ART 对亚临床心血管疾病的影响
- 批准号:
8983355 - 财政年份:2016
- 资助金额:
$ 162.13万 - 项目类别:
Effects of HIV, Cocaine, and Prolonged ART Use on Subclinical Cardiovascular Disease
HIV、可卡因和长期使用 ART 对亚临床心血管疾病的影响
- 批准号:
10377889 - 财政年份:2016
- 资助金额:
$ 162.13万 - 项目类别:
Changes in Coronary Noncalcified Volume in Relation to Changes in Cocaine Use
冠状动脉非钙化体积的变化与可卡因使用变化的关系
- 批准号:
8656319 - 财政年份:2013
- 资助金额:
$ 162.13万 - 项目类别:
Changes in Coronary Noncalcified Volume in Relation to Changes in Cocaine Use
冠状动脉非钙化体积的变化与可卡因使用变化的关系
- 批准号:
8534993 - 财政年份:2013
- 资助金额:
$ 162.13万 - 项目类别:
Changes in Coronary Noncalcified Volume in Relation to Changes in Cocaine Use
冠状动脉非钙化体积的变化与可卡因使用变化的关系
- 批准号:
8823757 - 财政年份:2013
- 资助金额:
$ 162.13万 - 项目类别:
HIV Infection, Cocaine Use and Coronary Artery Disease in HIV+ African Americans
HIV 感染、可卡因使用和 HIV 非洲裔美国人的冠状动脉疾病
- 批准号:
7883687 - 财政年份:2008
- 资助金额:
$ 162.13万 - 项目类别:
HIV Infection, Cocaine Use and Coronary Artery Disease in HIV+ African Americans
HIV 感染、可卡因使用和 HIV 非洲裔美国人的冠状动脉疾病
- 批准号:
7620770 - 财政年份:2008
- 资助金额:
$ 162.13万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 162.13万 - 项目类别:
Fellowship
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 162.13万 - 项目类别:
Continuing Grant
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 162.13万 - 项目类别:
Research Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 162.13万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 162.13万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 162.13万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 162.13万 - 项目类别:
EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 162.13万 - 项目类别:
Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 162.13万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 162.13万 - 项目类别:
Research Grant














{{item.name}}会员




