Clinical Pharmacoepidemiology Training Grant

项目摘要 生物统计学系，流行病学和信息学（DBEI），临床流行病学中心 药物流行病学研究和培训中心（CPeRT） 宾夕法尼亚大学（Penn）Perelman医学院提交此更新申请以继续 并提高我们的创新和非常成功的临床药理学博士后培训计划， 流行病学药物流行病学是研究药物和其他医疗器械的使用和影响的学科。 产品在人群中。我们的培训计划吸引了来自全国各地的高素质临床医生。 这个为期两到三年的强化临床研究培训计划旨在：1）培训临床医生， 是严谨和独立的调查人员能够制定研究问题，并使用广泛的 药物流行病学的方法来回答这些问题; 2）提供了一个基本的理解， 临床药理学原理; 3）与导师一起提供密集，监督的研究经验， 临床药物流行病学和其他内容领域的导师;和4）加强临床之间的联系 流行病学和临床药理学。为了学习临床研究的基础科学， 我们非常成功的临床流行病学硕士（MSCE）或流行病学博士学位 计划并完成临床流行病学，药物流行病学，结果的必修课程 测量，生物统计学和数据库管理;药物开发，药理学选修课程 以及与研究员的兴趣和经验有关的其他领域;独立阅读;参与 在DBEI/CCEB和CPeRT范围内开展研究研讨会和其他活动。这些技能适用于初级 培训计划的重点，即设计、实施、分析和出版 研究员设计的独立研究项目，以他们的独立研究职业目标为目标。 该计划的优势包括：1）大量经过临床培训的高素质候选人 在药物流行病学方面寻求严格的研究培训; 2）成功的研究培训的悠久历史 DBEI/CCEB的项目，包括药物流行病学和比较有效性 研究/以患者为中心的结果研究; 3）全面的课程设置和研究计划 提供给研究员;和4）项目主任和其他教师的成功培训记录。此外，本发明还提供了一种方法， CPeRT和其他CCEB教师的可用性，他们提供广泛的方法论专业知识 和临床学科;许多流行病学数据库对研究项目和培训有用;广泛的 一系列可用于临床研究的专业分析能力（例如，临床试验，病例对照，队列， 自我控制的设计）;和教师的承诺，合作研究和培训，联合收割机结合 为这个项目提供一个理想的环境。

Project Summary The Department of Biostatistics, Epidemiology, and Informatics (DBEI), the Center for Clinical Epidemiology and Biostatistics (CCEB) and the Center for Pharmacoepidemiology Research and Training (CPeRT) of the University of Pennsylvania (Penn) Perelman School of Medicine submit this renewal application to continue and improve our innovative and highly successful post-doctoral training program in clinical pharmaco- epidemiology. Pharmacoepidemiology is the study of the use and effects of medications and other medical products in populations. Our training program attracts highly qualified clinicians from across the nation. This two- to three-year intensive clinical research training program is designed to: 1) train clinicians to be rigorous and independent investigators able to formulate research questions and use a wide range of pharmacoepidemiologic approaches to answer those questions; 2) provide an understanding of the basic principles of clinical pharmacology; 3) provide intensive, supervised research experience with mentors in clinical pharmacoepidemiology and other content-area mentors; and 4) strengthen the links between clinical epidemiology and clinical pharmacology. To learn the basic sciences of clinical research, fellows matriculate in our highly-successful Master of Science in Clinical Epidemiology (MSCE) or PhD in Epidemiology degree programs and complete required courses in clinical epidemiology, pharmacoepidemiology, outcomes measurement, biostatistics, and database management; elective courses in drug development, pharmacology and other areas relevant to the fellows' interests and experience; independent readings; and participation in research seminars and other activities within DBEI/CCEB and CPeRT. These skills are applied to the primary focus of the training program, which is the design, implementation, analysis, and publication of mentored independent research projects of the fellow's design that targets their independent research career goals. Strengths of the program include: 1) the large pool of highly qualified candidates with clinical training seeking rigorous research training in pharmacoepidemiology; 2) the long history of successful research training programs in the DBEI/CCEB, including in pharmacoepidemiology and comparative effectiveness research/patient-centered outcomes research; 3) the comprehensive course offerings and research programs available to fellows; and 4) the successful training record of the program director and other faculty. In addition, the availability of the CPeRT and other CCEB faculty, who provide expertise in a wide range of methodologic and clinical disciplines; numerous epidemiologic databases useful for research projects and training; a broad array of specialized analytic capabilities available for clinical studies (e.g., clinical trials, case-control, cohort, self-controlled designs); and the faculty members' commitment to collaborative research and training, combine to provide an ideal environment for this program.