Clinical Pharmacoepidemiology Training Grant

描述（由申请人提供）：宾夕法尼亚大学（Penn）医学院临床流行病学和生物统计学中心（CCEB）提交此更新申请，以继续和扩展临床药物流行病学创新和成功的博士后培训计划（即，药物在人群中的使用和效果）。宾大提倡一种学术环境，鼓励基础和临床研究，并将其视为对学员有吸引力的职业道路。该培训项目吸引了来自全国其他机构的临床药物流行病学学员。预计该培训方案的许多毕业生将被安置在全国其他机构，从而产生最大影响的方案。 为期二至三年的培训计划包括临床流行病学，研究方法，生物统计学，药物流行病学，药代动力学的必修课程;药理学，药学实践或与学员兴趣和经验相关的其他领域的选修课程;广泛的独立阅读;参加CCEB的研究研讨会;临床药理学的临床经验;并完成了临床药物流行病学的指导独立研究项目。该方案旨在：1）培养临床医生成为严谨和独立的学术研究者，能够使用流行病学中可用的方法来解决临床药物流行病学中与病因学，预后，预防和早期发现，治疗，临床经济学，技术评估，医疗决策和患者护理质量相关的研究问题; 2）了解临床药理学的基本原则; 3）与临床药物流行病学导师一起提供密集，监督的研究经验; 4）与临床药物流行病学教师导师一起提供密切指导的研究经验; 5）加强传统流行病学和临床药理学之间的联系。随着这一培训方案的扩大，每年将颁发五个研究金名额。受训人员在临床流行病学（MSCE）学位课程的科学硕士录取。 拟议计划的优势是：1）寻求药物流行病学培训的极强候选人的大型库; 2）CCEB成功的研究培训计划的悠久历史，包括国际知名的临床药物流行病学计划和比较有效性研究的重叠培训（NIH感兴趣的新领域）; 3）提供给学员的全面课程和研究计划; 4）项目主任和教师的成功培训记录。此外，CCEB教师的可用性，他们提供广泛学科的专业知识;许多大型数据库可用于研究项目和培训;广泛的专业分析能力可用于临床研究（例如，临床试验、病例对照、队列研究等）;和学院的承诺，合作研究和培训，联合收割机结合起来，提供了一个理想的环境，这一计划。 公共卫生相关性：有一个主要的国家短缺合格的临床医生能够进行严格的研究，在临床药物流行病学。特别缺乏专注于药物安全性和比较有效性研究的临床研究人员。该培训计划通过杰出培训计划教师的努力解决了这一短缺问题。 这是一个具有出色研究资源和重点的机构内设置的程序的杰出竞争力更新。 调查人员非常出色，受训人员也卓有成效。

DESCRIPTION (provided by applicant): The Center for Clinical Epidemiology and Biostatistics (CCEB) of the University of Pennsylvania (Penn) School of Medicine submits this renewal application to continue and expand an innovative and successful post- doctoral training program in clinical pharmacoepidemiology (i.e., the use and effects of medications in populations). Penn promotes an academic environment in which basic and clinical research are encouraged and viewed as attractive career paths for trainees. This training program attracts clinical pharmacoepidemiology trainees from other institutions nationwide. It is anticipated that many graduates of this training program will be placed in other institutions nationwide, resulting in a program of the highest impact. The two- to three-year training program consists of required courses in clinical epidemiology, research methodology, biostatistics, pharmacoepidemiology, pharmacokinetics; elective courses in pharmacology, pharmacy practice, or other areas relevant to the trainees' interests and experience; extensive independent readings; participation in research seminars at the CCEB; clinical experiences in clinical pharmacology; and the completion of a mentored independent research project in clinical pharmacoepidemiology. The program is designed to: 1) train clinicians to be rigorous and independent academic investigators able to use the range of approaches available in epidemiology to address research issues in clinical pharmacoepidemiology related to the etiology, prognosis, prevention and early detection, treatment, clinical economics, technology assessment, medical decision making, and quality of patient care; 2) provide an understanding of the basic principles of clinical pharmacology; 3) provide intensive, supervised research experience with mentors in clinical pharmacoepidemiology; 4) provide closely mentored research experiences with faculty preceptors in clinical pharmacoepidemiology; and 5) strengthen the links between traditional epidemiology and clinical pharmacology. With the expansion of this training program, five fellowship slots will be awarded each year. Trainees matriculate in the Master of Science in Clinical Epidemiology (MSCE) degree program. Strengths of the proposed program are: 1) the large pool of extremely strong candidates seeking training in pharmacoepidemiology; 2) the long history of successful research training programs in the CCEB, including the internationally renowned clinical pharmacoepidemiology program and overlapping training in comparative effectiveness research (a new area of interest to NIH); 3) the comprehensive course offerings and research programs available to trainees; and 4) the successful training records of the program directors and faculty. In addition, the availability of the CCEB faculty, who provide expertise in a wide range of disciplines; numerous large databases useful for research projects and training; a broad array of specialized analytic capabilities available for clinical studies (e.g., clinical trials, case-control, cohort research, etc.); and the faculties' commitment to collaborative research and training, combine to provide an ideal environment for this program. PUBLIC HEALTH RELEVANCE: There is a major national shortage of qualified clinicians able to conduct rigorous research in clinical pharmacoepidemiology. There is a particular shortage of clinical investigators focusing on drug safety and comparative effectiveness research. This training program addresses this shortage through the efforts of distinguished training program faculty. This is an outstanding competitive renewal for a program set within an institution with excellent research resources and focus. The investigators are outstanding and the trainees have been productive and successful.