Clinical Pharmacoepidemiology Training Grant

 描述（由申请人提供）：临床流行病学和生物统计学中心（CCEB）和宾夕法尼亚大学（Penn）佩雷尔曼医学院药物流行病学研究和培训中心（CPeRT）提交此更新申请，以继续和扩展我们在临床药物流行病学方面的创新和非常成功的博士后培训计划。药物流行病学是研究药物和其他医疗产品在人群中的使用和影响。该培训计划吸引了来自全国各地的高素质学员。 这个为期两到三年的强化临床研究培训计划旨在：1）培养临床医生成为严谨和独立的学术研究者，能够制定研究问题并使用广泛的药物流行病学方法来回答这些问题; 2）了解临床药理学的基本原理; 3）与临床药物流行病学导师和内容领域导师一起提供密集的、受监督的研究经验;以及4）加强临床流行病学和临床药理学之间的联系。学员在我们非常成功的临床流行病学硕士（MSCE）学位课程录取，并完成临床流行病学，药物流行病学研究方法，结果测量，生物统计学，数据库管理，药代动力学的必修课程;药物开发，药理学和其他与学员的兴趣和经验相关的领域的选修课程;独立阅读;参加CCEB和CPeRT的研究研讨会;并完成学员设计的指导独立研究项目。鉴于该计划对名额的高需求，我们建议扩大该计划，每年支持五名研究员。 拟议计划的优势包括：1）大量高素质的候选人，他们接受过临床培训，寻求药物流行病学方面的严格研究培训; 2）CCEB成功的研究培训计划的悠久历史，包括药物流行病学和比较有效性研究/以患者为中心的结局研究; 3）为学员提供全面的课程和研究计划;（四）项目负责人和其他教师的成功培训记录。此外，CCEB和CPeRT教师的可用性，他们提供广泛的方法学和临床学科的专业知识;许多流行病学数据库可用于研究项目和培训;广泛的专业分析能力可用于临床研究（例如，临床试验、病例对照、队列、自身对照设计等）;以及教职员工对合作研究和培训的承诺，联合收割机结合起来，为这个项目提供了一个理想的环境。

 DESCRIPTION (provided by applicant): The Center for Clinical Epidemiology and Biostatistics (CCEB) and the Center for Pharmacoepidemiology Research and Training (CPeRT) of the University of Pennsylvania (Penn) Perelman School of Medicine submit this renewal application to continue and expand our innovative and highly successful post-doctoral training program in clinical pharmacoepidemiology. Pharmacoepidemiology is the study of the use and effects of medications and other medical products in populations. This training program attracts highly qualified trainees from across the nation. This intensive two- to three-year intensive clinical research training program is designed to: 1) train clinicians to be rigorous and independent academic investigators able to formulate research questions and use a wide range of pharmacoepidemiologic approaches to answer those questions; 2) provide an understanding of the basic principles of clinical pharmacology; 3) provide intensive, supervised research experience with mentors in clinical pharmacoepidemiology and content-area mentors; and 4) strengthen the links between clinical epidemiology and clinical pharmacology. Trainees matriculate in our highly-successful Master of Science in Clinical Epidemiology (MSCE) degree program, and complete required courses in clinical epidemiology, pharmacoepidemiology research methods, outcome measurement, biostatistics, database management, pharmacokinetics; elective courses in drug development, pharmacology and other areas relevant to the trainees' interests and experience; independent readings; participation in research seminars at the CCEB and CPeRT; and the completion of a mentored independent research project of the trainee's design. Given the high demand for slots in this program, we propose to expand this program to support five fellows per year. Strengths of the proposed program include: 1) the large pool of highly qualified candidates with clinical training seeking rigorous research training in pharmacoepidemiology; 2) the long history of successful research training programs in the CCEB, including in pharmacoepidemiology and comparative effectiveness research / patient centered outcomes research; 3) the comprehensive course offerings and research programs available to trainees; and 4) the successful training record of the program director and other faculty. In addition, the availability of the CCEB and CPeRT faculty, who provide expertise in a wide range of methodologic and clinical disciplines; numerous epidemiologic databases useful for research projects and training; a broad array of specialized analytic capabilities available for clinical studies (e.g., clinical trials, case-contrl, cohort, self- controlled designs, etc.); and the faculty members' commitment to collaborative research and training, combine to provide an ideal environment for this program.