Neural circuitry of sweet taste

甜味的神经回路

• 批准号: 8970753
• 负责人: Ivan E de Araujo
• 金额: $ 32.22万
• 依托单位: JOHN B. PIERCE LABORATORY, INC.
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8970753
• 关键词: Ablation; Address; Animal Model; Animals; Artificial Sweeteners; Basal Ganglia; Behavior; Behavioral; Biological Process; Brain; Brain Stem; Calories; Carbohydrates; Cells; Corpus striatum structure; Coupled; Cues; Detection; Dopamine; Dopaminergic Cell; Feeding behaviors; Generations; Ingestion; Investigation; Knowledge; Maps; Mediating; Metabolic; Methodology; Molecular; Motor; Mus; Neurons; Nutrient; Nutritional; Organism; Output; Population; Protocols documentation; Signal Transduction; Source; Substantia nigra structure; Sweetening Agents; Task Performances; Techniques; Thalamic structure; Tracer; Ventral Tegmental Area; Viral; Virus; Weight Gain; base; behavioral response; feeding; in vivo; interdisciplinary approach; interest; neural circuit; neurochemistry; optogenetics; public health relevance; response; sweet taste perception

 DESCRIPTION (provided by applicant): The biological function of sweet taste perception is to facilitate the detection of carbohydrate sources and trigger ingestive behavior. However, very little is known about how the neural circuitry that commands feeding senses the presence of nutrients in sweet substances. The aim of the studies outlined in this proposal is to start filling such fundamental gaps in our knowledge. Our investigations aim at providing a comprehensive functional circuit analysis of sweet taste activation of the basal ganglia - the major sensorimotor relay of the brain. We will specifically aim at identifying the basal ganglia circuits that sense te presence of nutrients in sweet substances. This will further our understanding of how sweet taste perception can modify the behavioral repertoire of an organism. Using the mouse as our model organism, we will employ a multidisciplinary approach that combines behavioral, neurochemical, electrophysiological, optogenetic, chemogenetic, and virus-based neuroanatomical tracing techniques. Accordingly, our Specific Aims are: Specific Aim 1: To characterize how basal ganglia circuits respond to sweet chemosensory signals Specific Aim 2: To generate a functional map of the circuits engendering behavioral responses to sweet chemosensory signals Specific Aim 3: To use molecular tracing techniques to identify the downstream targets of basal ganglia subcircuits mediating behavioral responses to nutritive sweet chemosensory signals.