Effect of lingual nerve injury on oromotor function

舌神经损伤对口运动功能的影响

• 批准号: 8771523
• 负责人: Susan H Williams
• 金额: $ 44.55万
• 依托单位: OHIO UNIVERSITY ATHENS
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8771523
• 关键词: Acute; Affect; Anesthesia procedures; Animal Model; Behavior; Behavior Control; Biomechanics; Bolus Infusion; Chronic; Complex; Data; Deglutition; Dental Care; Dentition; Disease; Dysesthesias; Eating; Electromyography; Ensure; Esthesia; Excision; Family suidae; Feeding behaviors; Fluoroscopy; Food; Foundations; Functional disorder; Goals; Human; Hypesthesia; Ingestion; Injury; Ipsilateral; Jaw; Knowledge; Lead; Lesion; Life; Location; Mastication; Methods; Morphology; Motion; Motor output; Movement; Muscle; Nerve; Nerve compression syndrome; Neuropathy; Numbness; Oral; Oral Stage; Oral cavity; Oropharyngeal; Outcomes Research; Output; Pain; Paresthesia; Patients; Phase; Physiological; Play; Quality of life; Rehabilitation Research; Reporting; Research; Resolution; Risk; Roentgen Rays; Role; Sensory; Solid; Staging; Structure; Sublingual Region; Testing; Tongue; Trauma; afferent nerve; base; craniofacial; design; feeding; innovation; insight; jaw movement; kinematics; lingual nerve; motor control; nerve injury; neurophysiology; neuroregulation; novel; oral behavior; oral biology; painful neuropathy; public health relevance; reconstruction; rehabilitation strategy; sensory integration; wisdom tooth

DESCRIPTION (provided by applicant): Eating plays a central role in everyday living and maintaining quality of life. Safe eating depends upon the integration of sensory information from the oral cavity to manage food. When oral sensation is negatively affected due to injury or disease, patients are at risk for not properly preparing solid foods for the swallow. The main sensory nerve of the tongue, the lingual nerve, is frequently compressed ("crushed") or transected during routine dental procedures (e.g., third molar removal) because of its anatomically unprotected location in the floor of the mouth. Lingual nerve injuries result in pain, altered or reduced sensation, and patients also report difficulties with feeding. However, the underlying biomechanical and functional basis of this oromotor dysfunction is unknown. The objective of this application is to understand how trauma to the lingual nerve impacts feeding behavior and the neural control and coordination of the tongue and jaw during feeding. The central hypothesis is that lingual nerve compression and transection injuries negatively impact sensorimotor integration of oral structures and, by extension, oral food management, but they do so in distinct ways. The effect of unilateral lingual nerve lesions will be investigated in the ig, an accepted animal model for human feeding biomechanics and oral function. Specific Aim 1 will use biplanar fluoroscopy and a novel motion analysis method, X-ray Reconstruction of Moving Morphology (XROMM), to determine the impact of these injuries on oromotor behavior. Specific Aim 2 will combine motion analysis with electromyography from jaw, oral and tongue muscles to understand the neurophysiological control of associated movements following these injuries. Both aims will identify functional changes and compensatory mechanisms in the tongue and jaw following lingual sensory disturbances. This research is innovative because it focuses on 1) the effect of two distinct types of sensory disturbances on motor output and control and 2) the pre-swallowing feeding stages rather than on the oropharyngeal swallow, the focus of most feeding rehabilitation research. Unlike swallowing, the oral stages of feeding require bilaterally asymmetrical movements and motor control. This project is methodologically innovative in its use of XROMM, which allows the synchronization of high resolution 3D tongue and jaw movements with electromyograms from muscles controlling these movements. This is expected to lead to new insights into the role of the tongue during the oral stages of feeding and changes in its function resulting from sensory disturbances. The proposed research is significant because lingual nerve injuries are surprisingly common, and understanding their impact on oromotor output can benefit the design of rehabilitation strategies to restore oral function.

描述（由申请人提供）：饮食在日常生活和维持生活质量中起着核心作用。安全饮食依赖于口腔感官信息的整合来管理食物。当口腔感觉因受伤或疾病而受到负面影响时，患者有可能无法正确准备吞咽固体食物。舌头的主要感觉神经，舌神经，在常规牙科手术（例如，第三磨牙移除），因为其在口底的解剖学上不受保护的位置。舌神经损伤会导致疼痛， 感觉改变或减少，患者还报告进食困难。然而，这种骨科功能障碍的生物力学和功能基础尚不清楚。本申请的目的是了解舌神经创伤如何影响进食行为以及进食过程中舌头和下颌的神经控制和协调。中心假设是，舌神经压迫和横断损伤对口腔结构的感觉运动整合产生负面影响，进而影响口腔食物管理，但它们的影响方式不同。单侧舌神经损伤的影响将在IG中研究，ig是人类进食生物力学和口腔功能的公认动物模型。具体目标1将使用双平面荧光透视和一种新的运动分析方法，运动形态X射线重建（XROMM），以确定这些损伤对骨科行为的影响。具体目标2将结合联合收割机运动分析与肌电图从下巴，口腔和舌头的肌肉，以了解神经生理控制的相关运动后，这些伤害。这两个目标将确定功能的变化和补偿机制，在舌头和下巴后舌感觉障碍。这项研究具有创新性，因为它重点关注1）两种不同类型的感觉障碍对运动输出和控制的影响，以及2）吞咽前进食阶段，而不是口咽吞咽，这是大多数进食康复研究的重点。与吞咽不同，喂食的口腔阶段需要双侧不对称的运动和运动控制。该项目在使用XROMM的方法上是创新的，它允许高分辨率的3D舌头和下巴运动与控制这些运动的肌肉的肌电图同步。预计这将导致对舌头在喂食的口腔阶段的作用以及感觉障碍导致的功能变化的新见解。这项研究意义重大，因为舌神经损伤非常常见，了解它们对口腔输出的影响有助于设计恢复口腔功能的康复策略。

项目成果

Characterizing tongue deformations during mastication using changes in planar components of three-dimensional angles.

• DOI: 10.1098/rstb.2022.0555
• 发表时间: 2023-12-04
• 期刊: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
• 影响因子: 6.3
• 作者: Olson, Rachel A.;Montuelle, Stephane J.;Williams, Susan H.
• 通讯作者: Williams, Susan H.

Flexibility of feeding movements in pigs: effects of changes in food toughness and stiffness on the timing of jaw movements.

猪采食运动的灵活性：食物韧性和硬度变化对下颌运动时间的影响。

• DOI: 10.1242/jeb.168088
• 发表时间: 2018
• 期刊: The Journal of experimental biology
• 作者: Montuelle,StéphaneJ;Olson,Rachel;Curtis,Hannah;Sidote,JoAnna;Williams,SusanH
• 通讯作者: Williams,SusanH

Regional Tongue Anatomy and Corresponding Kinematics During Chewing and Drinking in the Pig.

猪咀嚼和饮水过程中的区域舌头解剖学和相应的运动学。

• 发表时间: 2022
• 期刊: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
• 作者: Olson,RachelA;Montuelle,StephaneJ;Curtis,Hannah;Chadwell,Brad;Williams,SusanH
• 通讯作者: Williams,SusanH