Developmental Functions of the MNS: Social anticipation and imitation

MNS 的发育功能：社会预期和模仿

• 批准号: 8701316
• 负责人: AMANDA L WOODWARD
• 金额: $ 32.09万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8701316
• 关键词: Address; Adult; Autistic Disorder; Behavioral; Child; Code; Cognitive; Computer Simulation; Data; Development; Developmental Process; Disease; Educational process of instructing; Electroencephalogram; Eye; Functional disorder; Generations; Goals; Human; Individual; Infant; Infant Development; Investigation; Laboratories; Lead; Left; Life; Light; Link; Measures; Methods; Motor; Movement; Outcome; Pattern; Perception; Primates; Process; Production; Property; Recruitment Activity; Research; Role; Shapes; Social Functioning; Social Perception; Specific qualifier value; Structure; Support System; System; Testing; Training; behavior measurement; contextual factors; developmental disease; experience; infancy; information processing; insight; mirror neuron; mirror neuron system; neural patterning; neurophysiology; relating to nervous system; research study; response; social

Converging evidence from across laboratories and approaches has documented the existence of shared neural representations for the perception and production of action (termed mirror neurons or the mirror neuron system, MNS) in adult nonhuman and human primates. Although it is widely hypothesized that the MNS supports the development of social perception and social responses, there is little direct investigation of these possibilities. The proposed experiments address this issue by investigating the potential role of the MNS in the development of two foundational social abilities: action anticipation, the ability to generate predictions about the outcomes of others' actions, and goal imitation, the ability to reproduce the meaningful components of others' actions. The first goal of the proposed research is to use behavioral methods to test the hypothesis that developing action production systems support infants' abilities to anticipate and imitate others' actions. To this end. Panel 1 develops eye-tracking measures of action anticipation and Panel 2 develops behavioral measures of goal imitation. Each panel will investigate relations between the focal ability and infants' own developing actions, as well as the effects of motor training and motor interference. In addition, drawing on insights from Project III, these studies will test whether infants' anticipatory and imitative responses are modulated by the contextual factors that modulate mirror neuron function in primates. The second goal of the proposed research is to implement these measures in studies that assess the neural processes that correlate with infants' action anticipation and goal imitation. The studies in Panel 3 pursue this goal by integrating the behavioral measures developed in Panels 1 and 2 with electroencephalogram (EEG) studies of mu rhythm suppression, a neural response that has been argued to reflect MNS activation. To achieve this goal, the studies will draw on methods developed in Projects I and IV. In addition to addressing these two primary research goals, the data from these experiments will be recruited to inform the development of computational models in Project IV.

来自不同实验室和方法的聚合证据证明了共享的存在 感知和产生动作的神经表征(称为镜像神经元或镜像 在成年非人灵长类和人类灵长类动物中。尽管人们普遍认为， MNS支持社会认知和社会反应的发展，很少有直接调查 这些可能性。拟议中的实验通过研究 MNS在发展两种基本社会能力中的作用：行动预期能力、生成能力 对他人行为结果的预测，以及目标模仿，即复制有意义的 其他人行为的组成部分。 提出的研究的第一个目标是使用行为方法来检验以下假设 开发动作生产系统支持婴儿预测和模仿他人动作的能力。为了这个目的。小组1开发了行动预期的眼动跟踪测量，小组2开发了目标模仿的行为测量。每个小组将调查注意力集中能力与婴儿自身发展行为之间的关系，以及运动训练和运动干扰的效果。此外，这些研究将借鉴项目III的见解，测试婴儿的预期和模仿反应是否受到调节灵长类镜像神经元功能的环境因素的影响。 这项拟议研究的第二个目标是在评估与婴儿的行动预期和目标模仿相关的神经过程的研究中实施这些措施。小组3中的研究通过将小组1和小组2中开发的行为测量与 Mu节律抑制的脑电(EEG)研究，一种被认为反映MNS激活的神经反应。为实现这一目标，研究将借鉴项目一和项目四中制定的方法。 除了解决这两个主要研究目标外，这些实验的数据将是 受聘为项目四中计算模型的开发提供信息。