vivaCT80 - in vivo small animal microCT

vivaCT80 - 小动物体内显微 CT

• 批准号: 8639867
• 负责人: Daniel S Perrien
• 金额: $ 41.4万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8639867
• 关键词: Acute; Affect; Alzheimer' s Disease; Animals; Collaborations; Communicable Diseases; Ensure; Fostering; Funding; Grant; Housing; Image; Institutes; Institution; Life; Low Dose Radiation; Magnetic Resonance Imaging; Malignant neoplasm of prostate; Manufacturer Name; Multiple Myeloma; Mus; Optics; Pilot Projects; Positron-Emission Tomography; Primates; Research Project Grants; Resolution; Scanning; Science; Soft Tissue Neoplasms; Specimen; System; Time; United States National Institutes of Health; Universities; X-Ray Computed Tomography; angiogenesis; attenuation; bone quality; drug development; imaging modality; improved; in vivo; instrument; malignant breast neoplasm; repaired; skeletal; substantia spongiosa; success

DESCRIPTION (provided by applicant): This application is to replace an existing microCAT that already supports multiple NIH-funded projects but is failing and cannot be repaired. The replacement system will support all of the current projects and have higher resolution, faster scan time, and lower radiation dose that will enable new applications, expanding usage to additional research projects. In vivo micro computed tomography systems are used for non-destructive three dimensional analyses of synthetic, ex vivo specimens, and, most importantly, live animals. Two of the four quadrants on our existing microCAT II have failed and cannot be repaired because the manufacturer of that instrument no longer supports parts replacement. The proposed vivaCT80 system is the first and only in vivo microCT system currently available that can produce images at a resolution sufficient for analysis of murine trabecular bone and microvasculature, low radiation dose, and possesses a bore size large enough to accommodate animals as large as small primates. Many current users depend on in vivo microCT for coregistration and attenuation calculations with PET, MRI, and optical CT (FMT, Visen). Hence, the loss of in vivo microCT imaging capabilities will affect multiple imaging platforms and projects across a wide range of biomedical fields. Thus, the vivCT80 will provide years of stable support for existing users and expand numerous, wide ranging, NIH funded projects as well as pilot projects for new users and projects. Supported projects study angiogenesis, skeletal consequences of breast and prostate cancer and multiple myeloma, bone quality, endochondral ossification, Alzheimer's disease, drug development, acute infectious disease, and a range of soft tissue tumors, among others. Aspects of each of these projects either require or will be substantially enhanced by reliable, fast, in vivo microCT imaging. Due to its improved capabilities, the vivaCT80 will undoubtedly foster collaborations within Vanderbilt University and at neighboring institutions. Housing this instrument in the Vanderbilt University Institute for Imaging Science (VUIIS), which has been highly successful in managing numerous imaging modalities, will ensure campus wide access and superior management. Acquisition of a new in vivo microCT is absolutely critical to the continued success of many NIH- funded grants at Vanderbilt.

描述（由申请人提供）：此应用程序将替换现有的microCAT，该microCAT已经支持多个NIH资助的项目，但失败且无法修复。新系统将支持所有现有项目，并具有更高的分辨率、更快的扫描时间和更低的辐射剂量，这将使新的应用成为可能，并将使用范围扩大到其他研究项目。体内微型计算机断层扫描系统用于非破坏性的三维分析的合成，离体标本，最重要的是，活的动物。我们现有的microCAT II上的四个象限中有两个出现故障，无法修复，因为该仪器的制造商不再支持零件更换。所提出的vivaCT 80系统是目前第一个也是唯一一个可用的体内microCT系统，其可以产生足够用于分析鼠骨小梁和微血管的分辨率的图像，低辐射剂量，并且具有足够大的孔径以容纳像小型灵长类动物一样大的动物。目前，许多用户依赖于体内microCT与PET、MRI和光学CT（FMT，Visen）进行配准和衰减计算。因此，体内microCT成像能力的丧失将影响广泛的生物医学领域的多个成像平台和项目。因此，vivCT 80将为现有用户提供多年的稳定支持，并为新用户和项目扩展众多、广泛的NIH资助项目以及试点项目。支持的项目研究血管生成，乳腺癌和前列腺癌和多发性骨髓瘤的骨骼后果，骨质，软骨内骨化，阿尔茨海默病，药物开发，急性传染病和一系列软组织肿瘤等。这些项目中的每一个方面都需要或将通过可靠、快速的体内microCT成像得到实质性增强。由于其改进的能力，vivaCT 80无疑将促进范德比尔特大学和邻近机构的合作。在范德比尔特大学成像科学研究所（VUIIS）中安装该仪器，将确保校园范围内的访问和上级管理，该研究所在管理众多成像模式方面非常成功。获得一种新的体内微型CT对范德比尔特许多NIH资助的赠款的持续成功绝对至关重要。