Development of targeting nanotherapeutics against bladder cancer
膀胱癌靶向纳米疗法的开发
基本信息
- 批准号:8442030
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-10-01 至 2017-09-30
- 项目状态:已结题
- 来源:
- 关键词:BindingBiocompatibleBladderBlood CellsCalmette-Guerin BacillusCancer ControlCancer cell lineCanis familiarisCellsChronic CystitisClinicalCompanionsDataDetectionDevelopmentDoctor of MedicineDoctor of PhilosophyDrug Delivery SystemsDrug FormulationsDrug KineticsFibroblastsFundingGoalsHomingHumanImageImmunocompromised HostK-Series Research Career ProgramsKnowledgeLigandsMalignant NeoplasmsMalignant neoplasm of lungMalignant neoplasm of urinary bladderMentorsMonitorMusNamesOrganPaclitaxelPatientsPeptidesPharmaceutical PreparationsPharmacology and ToxicologyPilot ProjectsSiteSpecimenStructureSurfaceSystemTherapeuticTherapeutic EffectTimeToxic effectTreatment EfficacyTreatment outcomeUrothelial CellVascular Endothelial CellWorkXenograft procedurecancer celldensitydrug distributiondrug efficacyimprovedin vivointravenous injectionnanotherapeuticnoveloutcome forecastpeptide analogpreclinical studypublic health relevancetargeted deliverytumor xenograft
项目摘要
DESCRIPTION (provided by applicant):
The goal of this project is to develop a nanomicelle drug delivery system that can specifically target bladder cancer. With the funding of the VA Career Development Award-2 (CDA-2, PI: Pan), a bladder cancer-targeting ligand named PLZ4 was developed. PLZ4 binds to both human and dog bladder cancer cell lines and cancer cells from clinical specimens, suggesting that the pre-clinical studies can be performed in dogs with spontaneous bladder cancer. PLZ4 does not bind to normal urothelial cells, inflamed bladder cells, blood cells, vascular endothelial cells an fibroblasts. Recently, Kit Lam, MD, PhD, (Dr. Pan's VA CDA-2 mentor) developed biocompatible and biodegradable nanomicelles. Chemotherapeutic and imaging agents can be loaded inside the nanomicelles. When they are decorated with PLZ4 on surface, these targeting nanomicelles together with the drug load are delivered into bladder cancer cells. Targeting PLZ4-nanomicelles preferentially concentrate at the bladder cancer xenograft sites in vivo and can significantly prolong survival when compared to non-targeting nanomicelles. In this project, we will optimize the structure of the PLZ4-nanomicelles to achieve the maximal drug loading and delivery, and determine the in vivo targeting and drug distribution in mice carrying bladder cancer xenografts developed from human clinical specimens. A pilot study will be conducted in dog patients carrying spontaneous bladder cancer in order to obtain the preliminary toxicity and efficacy data.
PUBLIC HEALTH RELEVANCE:
This project aims to develop a multi-functional nanomicelle drug delivery system that can specifically deliver the chemotherapeutic drug paclitaxel to bladder cancer. The nanomicelle system can possibly improve treatment efficacy and lower therapy-associated toxicity.
描述(由申请人提供):
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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CHONG-XIAN PAN其他文献
CHONG-XIAN PAN的其他文献
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{{ truncateString('CHONG-XIAN PAN', 18)}}的其他基金
BCCMA: Translational research to improve the care of advanced bladder cancer
BCCMA:改善晚期膀胱癌护理的转化研究
- 批准号:
10588312 - 财政年份:2023
- 资助金额:
-- - 项目类别:
A Phase I trial of cancer-targeting micelles for non-myoinvasive bladder cancer
癌症靶向胶束治疗非肌浸润性膀胱癌的 I 期试验
- 批准号:
10426035 - 财政年份:2020
- 资助金额:
-- - 项目类别:
A Phase I trial of cancer-targeting micelles for non-myoinvasive bladder cancer
癌症靶向胶束治疗非肌浸润性膀胱癌的 I 期试验
- 批准号:
10578717 - 财政年份:2020
- 资助金额:
-- - 项目类别:
Potentiation of Immunotherapy with targeted nanoporphyrin in bladder cancer
靶向纳米卟啉增强膀胱癌的免疫治疗
- 批准号:
10158416 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Potentiation of Immunotherapy with targeted nanoporphyrin in bladder cancer
靶向纳米卟啉增强膀胱癌的免疫治疗
- 批准号:
9898243 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Potentiation of Immunotherapy with targeted nanoporphyrin in bladder cancer
靶向纳米卟啉增强膀胱癌的免疫治疗
- 批准号:
10085104 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Targeted-and timed-releasing nanotherapeutics against leukemia stem cells
针对白血病干细胞的靶向定时释放纳米疗法
- 批准号:
10162055 - 财政年份:2015
- 资助金额:
-- - 项目类别:
Targeted- and timed-releasing nanotherapeutics against leukemia stem cells
针对白血病干细胞的靶向和定时释放纳米疗法
- 批准号:
9260776 - 财政年份:2015
- 资助金额:
-- - 项目类别:
Targeted- and timed-releasing nanotherapeutics against leukemia stem cells
针对白血病干细胞的靶向和定时释放纳米疗法
- 批准号:
9454297 - 财政年份:2015
- 资助金额:
-- - 项目类别:
Development of targeting nanotherapeutics against bladder cancer
膀胱癌靶向纳米疗法的开发
- 批准号:
9275369 - 财政年份:2013
- 资助金额:
-- - 项目类别:
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