Targeted- and timed-releasing nanotherapeutics against leukemia stem cells

针对白血病干细胞的靶向和定时释放纳米疗法

基本信息

  • 批准号:
    9454297
  • 负责人:
  • 金额:
    $ 35.91万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-04-15 至 2020-03-31
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): The goal of this project is to develop nanotherapeutics that can specifically deliver the chemotherapeutic drug daunorubicin into acute myeloid leukemia (AML) stem cells (targeted delivery) and release the drug inside the cells (timed release) in order to eradicate this cell population. Current chemotherapy for AML is disappointing in that it can cure only a minority of AML patients and is associated with severe toxicity and significant mortality even with intensive inpatient monitoring and supportive care. Leukemia stem cells (LSC) are relatively resistant to the conventional chemotherapy and can subsequently produce more leukemia cells to cause disease recurrence. In order to cure leukemia, LSC must be eradicated. The C-type lectin-like molecule-1 (CLL-1) is a cell surface protein that is specifically expressed on most AML LSC, but not on normal hematopoietic stem cells. We have developed a peptide that specifically targets CLL1. When this peptide is covalently attached to a nanometer-scale micellar drug formulation, the resulted targeting nanoparticles, called micelles, can specifically deliver the drug load into cells expressing CLL1, including clinical leukemia specimens. The drug-loaded, CLL1-targeting micelles are stable in blood, and can potentially improve therapy against AML by (1) delivering a high local concentration of daunorubicin specifically into LSC, overwhelming the resistant mechanisms and eradicating LSC; (2) killing leukemic cells throughout the body with the release of daunorubicin from the micelles and LSC into circulation; (3) decreasing therapy-induced toxicity and mortality owing to the sequestration of the drug inside the micelles; and (4) allowing administration of high-dose daunorubicin with reduced toxicity through formulation of daunorubicin into micelles.


项目成果

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CHONG-XIAN PAN其他文献

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{{ truncateString('CHONG-XIAN PAN', 18)}}的其他基金

BCCMA: Translational research to improve the care of advanced bladder cancer
BCCMA:改善晚期膀胱癌护理的转化研究
  • 批准号:
    10588312
  • 财政年份:
    2023
  • 资助金额:
    $ 35.91万
  • 项目类别:
A Phase I trial of cancer-targeting micelles for non-myoinvasive bladder cancer
癌症靶向胶束治疗非肌浸润性膀胱癌的 I 期试验
  • 批准号:
    10426035
  • 财政年份:
    2020
  • 资助金额:
    $ 35.91万
  • 项目类别:
A Phase I trial of cancer-targeting micelles for non-myoinvasive bladder cancer
癌症靶向胶束治疗非肌浸润性膀胱癌的 I 期试验
  • 批准号:
    10578717
  • 财政年份:
    2020
  • 资助金额:
    $ 35.91万
  • 项目类别:
Potentiation of Immunotherapy with targeted nanoporphyrin in bladder cancer
靶向纳米卟啉增强膀胱癌的免疫治疗
  • 批准号:
    10158416
  • 财政年份:
    2018
  • 资助金额:
    $ 35.91万
  • 项目类别:
Potentiation of Immunotherapy with targeted nanoporphyrin in bladder cancer
靶向纳米卟啉增强膀胱癌的免疫治疗
  • 批准号:
    9898243
  • 财政年份:
    2018
  • 资助金额:
    $ 35.91万
  • 项目类别:
Potentiation of Immunotherapy with targeted nanoporphyrin in bladder cancer
靶向纳米卟啉增强膀胱癌的免疫治疗
  • 批准号:
    10085104
  • 财政年份:
    2018
  • 资助金额:
    $ 35.91万
  • 项目类别:
Targeted-and timed-releasing nanotherapeutics against leukemia stem cells
针对白血病干细胞的靶向定时释放纳米疗法
  • 批准号:
    10162055
  • 财政年份:
    2015
  • 资助金额:
    $ 35.91万
  • 项目类别:
Targeted- and timed-releasing nanotherapeutics against leukemia stem cells
针对白血病干细胞的靶向和定时释放纳米疗法
  • 批准号:
    9260776
  • 财政年份:
    2015
  • 资助金额:
    $ 35.91万
  • 项目类别:
Development of targeting nanotherapeutics against bladder cancer
膀胱癌靶向纳米疗法的开发
  • 批准号:
    8442030
  • 财政年份:
    2013
  • 资助金额:
    $ 35.91万
  • 项目类别:
Development of targeting nanotherapeutics against bladder cancer
膀胱癌靶向纳米疗法的开发
  • 批准号:
    9275369
  • 财政年份:
    2013
  • 资助金额:
    $ 35.91万
  • 项目类别:

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自体干细胞移植后的 HIV 储库和基因修饰细胞动力学
  • 批准号:
    10700521
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  • 批准号:
    10392164
  • 财政年份:
    2022
  • 资助金额:
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Systematic Light Exposure Effects on Circadian Rhythms Entrainment, Inflammation, Neutropenic Fever and Symptom Burden among Multiple Myeloma Patients undergoing Autologous Stem Cell Transplantation
系统性光照对接受自体干细胞移植的多发性骨髓瘤患者的昼夜节律拖累、炎症、中性粒细胞减少性发热和症状负担的影响
  • 批准号:
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  • 财政年份:
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Preventing Myeloma Relapse after Autologous Stem Cell Transplantation with Decoy Resistant IL-18
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自体干细胞移植后优化骨髓瘤特异性免疫
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自体干细胞移植预防Crow-Fukase综合征大剂量化疗后复发
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