Aerobic Plus Resistance Training to Increase Insulin Sensitivity in African Ameri

描述（由申请人提供）：迄今为止，还没有一个大规模的，随机的，对照研究检查运动训练的好处糖尿病风险因素，主要是胰岛素抵抗，在非洲裔美国男性。全国标准化估计显示，20岁及以上的所有非洲裔美国人中有15%至20%患有糖尿病（包括确诊和未确诊的）。定期的体力活动是糖尿病发展的一个可改变的风险因素。虽然已经证明，运动训练可以减少高加索成年人的糖尿病发病率，但不能假设高加索成年人的益处也适用于其他种族的男性。这些类型的研究通常在大学环境中进行，与基于社区的计划相比，这可能是非洲裔美国人参与者的障碍。因此，我们提议进行一项基于社区的随机试验，评估定期锻炼对非裔美国男性队列中糖尿病危险因素的影响。这项提案的标题是有氧加阻力训练，以增加胰岛素敏感性的非洲裔美国人（ARTIIS）。研究组将由35至70岁的久坐不动的健康非裔美国男性组成。在这个年龄组，我们招募的男性患糖尿病的风险最高，因此，这组人可能会从锻炼计划中受益。运动训练组的男性将进行150分钟的有氧运动，以及2天的力量训练。目标运动强度为VO 2 max（有氧）的50-70%和1 RM（力量）的50-80%。该运动剂量与当前的国家体力活动建议一致，因此，ARTIIS将协助确定当前的建议是否对非裔美国男性的健康有益。我们认识到，非洲裔美国男性是一个难以接触的人口。为了确保成功参与，我们将利用社区健身设施来提供该计划。因此，运动训练组的男性将能够在他们的社区中锻炼。主要结果指标是糖尿病的风险因素，包括胰岛素对葡萄糖负荷的反应、空腹胰岛素和c肽。次要结果是心血管健康、肌肉力量、体重和成分以及心理结果。

DESCRIPTION (provided by applicant): To date, there has not been a large-scale, randomized, controlled study examining the benefits of exercise training the diabetes risk factor, mainly insulin resistance, in African American males. National standardized estimates show that between 15% and 20% of all African Americans aged twenty and older have diabetes (including both diagnosed and undiagnosed). Regular physical activity is a modifiable risk factor for the development of diabetes. Although it has been shown that exercise training results in a reduction of diabetes in Caucasian adults, it cannot be assumed that the benefits derived in Caucasian adults apply to men of other ethnic groups. These types of studies are typically conducted at the university setting, which can be a barrier for African American participants compared to a community-based program. Therefore, we proposed to a randomized community-based trial assessing the effect of regular exercise on risk factors for diabetes in an exclusively African American male cohort. This proposal is entitled Aerobic Plus Resistance Training to Increase Insulin Sensitivity in African American Men (ARTIIS). The study group will consist of sedentary, healthy African American men aged 35 to 70 years. At this age group, we are recruiting men who are at the highest risk of developing diabetes and therefore, the group who is likely to benefit from an exercise program. Males in the exercise training group will engage in 150 minutes of aerobic activity, as well as 2 days of strength training. The target exercise intensity is 50-70% of VO2 max (aerobic) and 50-80% of 1RM (strength). This exercise dose is consistent with the current national physical activity recommendations, and therefore, ARTIIS will assist in determining if the current recommendations result in health benefits for African American males. We recognize that African American males are a difficult-to-reach population. In order to ensure successful participation we will utilize community-based fitness facilities to deliver the program. Thus males in the exercise training group will be able to exercise in their community. Primary outcome measures are risk factors for diabetes including insulin response to a glucose load, fasting insulin, and c-peptide. Secondary outcomes are cardiovascular fitness, muscular strength, body weight and composition, and psychological outcomes.