Aerobic Plus Resistance Training to Increase Insulin Sensitivity in African Ameri

有氧加阻力训练可提高非裔美国人的胰岛素敏感性

基本信息

批准号：
8462973
负责人：
Robert Lee Newton
金额：
$ 40.13万
依托单位：
LSU PENNINGTON BIOMEDICAL RESEARCH CTR
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-05-01 至 2016-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8462973
关键词：
Address Adult Aerobic Aerobic Exercise African African American American Body Composition Body Weight Cardiovascular system Caucasians Caucasoid Race Church Communities Control Groups Data Development Diabetes Mellitus Diabetes prevention Diagnosis Dose Educational Intervention Effectiveness Ensure Equipment Ethnic group Exercise Fasting Female Glucose Goals Guidelines Health Health Benefit Hour Insulin Insulin Resistance Intervention Intervention Studies Knowledge Lead Measures Modeling Monitor Muscle National Institute of Diabetes and Digestive and Kidney Diseases OGTT Outcome Outcome Measure Participant Peptides Physical activity Population Prevention Program Sustainability Randomized Randomized Controlled Trials Recommendation Recreation Recruitment Activity Research Design Research Project Grants Resistance Risk Risk Factors Sampling Schedule Social Network Structure Testing Training Training Programs Universities age group aged base cohort design diabetes risk fitness health disparity high risk insulin sensitivity male men modifiable risk primary outcome programs psychological outcomes response secondary outcome sedentary strength training

项目摘要

DESCRIPTION (provided by applicant): To date, there has not been a large-scale, randomized, controlled study examining the benefits of exercise training the diabetes risk factor, mainly insulin resistance, in African American males. National standardized estimates show that between 15% and 20% of all African Americans aged twenty and older have diabetes (including both diagnosed and undiagnosed). Regular physical activity is a modifiable risk factor for the development of diabetes. Although it has been shown that exercise training results in a reduction of diabetes in Caucasian adults, it cannot be assumed that the benefits derived in Caucasian adults apply to men of other ethnic groups. These types of studies are typically conducted at the university setting, which can be a barrier for African American participants compared to a community-based program. Therefore, we proposed to a randomized community-based trial assessing the effect of regular exercise on risk factors for diabetes in an exclusively African American male cohort. This proposal is entitled Aerobic Plus Resistance Training to Increase Insulin Sensitivity in African American Men (ARTIIS). The study group will consist of sedentary, healthy African American men aged 35 to 70 years. At this age group, we are recruiting men who are at the highest risk of developing diabetes and therefore, the group who is likely to benefit from an exercise program. Males in the exercise training group will engage in 150 minutes of aerobic activity, as well as 2 days of strength training. The target exercise intensity is 50-70% of VO2 max (aerobic) and 50-80% of 1RM (strength). This exercise dose is consistent with the current national physical activity recommendations, and therefore, ARTIIS will assist in determining if the current recommendations result in health benefits for African American males. We recognize that African American males are a difficult-to-reach population. In order to ensure successful participation we will utilize community-based fitness facilities to deliver the program. Thus males in the exercise training group will be able to exercise in their community. Primary outcome measures are risk factors for diabetes including insulin response to a glucose load, fasting insulin, and c-peptide. Secondary outcomes are cardiovascular fitness, muscular strength, body weight and composition, and psychological outcomes.

描述（由申请人提供）：迄今为止，还没有进行大规模的，随机的，对照的研究，研究了运动训练糖尿病危险因素，主要是胰岛素抵抗的益处。全国标准化估计表明，所有二十岁以上的非裔美国人中有15％至20％患有糖尿病（包括被诊断和未被诊断的糖尿病）。常规身体活动是糖尿病发展的可修改风险因素。尽管已经表明，运动训练会导致白人成年人的糖尿病减少，但不能假定高加索成年人衍生的益处适用于其他种族的男性。这些类型的研究通常是在大学环境中进行的，与社区计划相比，这可能是非裔美国人参与者的障碍。因此，我们提出了一项基于社区的随机试验，该试验评估了常规运动对仅非裔美国人男性队列中糖尿病危险因素的影响。该提案的标题为有氧运动和抵抗训练，以提高非洲裔美国男性（ARTIIS）的胰岛素敏感性。研究小组将包括35至70岁的久坐健康的非洲裔美国男性。在这个年龄段，我们正在招募患糖尿病风险最高的男性，因此，可能会从运动计划中受益的小组。运动训练小组中的男性将参加150分钟的有氧运动以及2天的力量训练。目标运动强度为VO2 MAX（有氧运动）的50-70％和1RM（强度）的50-80％。这种运动剂量与当前的国家体育锻炼建议一致，因此，Artiis将有助于确定当前的建议是否会对非裔美国人男性带来健康益处。我们认识到非裔美国人是一个难以到达的人群。为了确保成功参与，我们将利用基于社区的健身设施来提供该计划。因此，运动训练小组中的男性将能够在其社区中运动。主要结局指标是糖尿病的危险因素，包括胰岛素对葡萄糖负荷，空腹胰岛素和C肽的反应。次要结果是心血管健康，肌肉力量，体重和组成以及心理结局。