CORE C- DATA MANAGEMENT AND STATISTICS

这个数据管理和统计核心(Core C)在研究中起到了至关重要的作用 该计划已有20年的历史。数据管理和统计核心将继续为 总体研究计划和每个组成部分项目(项目1-3)，以及动物 资源(核心B)。 该核心将为其各自下属的所有项目提供统计和实验设计方面的专业知识 研究计划。核心的这一功能在设计和分析实验中至关重要，这些实验提供了 日益复杂的数据，可能受益于项目专业知识之外的分析方法 领袖们。具有统计专业知识的核心C级人员将参加所有研究规划会议(AS 在核心A中详细描述)。在进行研究的过程中继续与调查人员磋商， 数据分析和出版物的编写将在该核心和项目之间进行。在这些 活动核心最大限度地加强所有项目组件之间的沟通，以进一步了解 要分析的数据、这些分析的统计程序以及对调查结果的适当解释。 该核心继续开发和实施数据管理战略，以处理和记录所有 在核心B(动物资源)和项目中收集的数据。通过其数据管理活动， 核心将继续建立在这一支助机制下产生的数据的档案。因为所有数据 都与AI和AU大鼠的年龄和认知状态有关，每个受试者都有一个唯一的识别符 跨数据集链接主题数据，在此动物模型中存在许多比较数据的机会 跨研究和跨项目。这些档案服务于调查组的所有成员，并构成 在神经认知老化领域非常有价值的信息基础。核心C的具体人员是 负责数据库资源开发和数据管理。 大型数据档案(例如来自动物资源、微阵列的行为数据和健康记录 基础和实验条件下的数据集)以可访问的格式进行管理，以供内部使用 在方案项目内部和与外部调查人员共享数据，后者在监督下 核心A的。

This Data Management and Statistics Core (Core C) has played an essential role in the research program over its 20 year history. The Data Management and Statistics Core will continue to serve the overall research program and each of the component projects (Projects 1-3), along with the Animal Resource (Core B). The Core will provide expertise in statistics and experimental design to all projects under their respective research plans. This function of the Core is critical in the design and analysis of experiments that provide increasingly complex data and may benefit from analytical methods beyond the expertise of Project Leaders. Core C personnel with statistical expertise will participate in all research planning meetings (as described in detail in Core A). Continued consultation with investigators during the conduct of the research, data analysis, and preparation of publications will occur between this Core and the Projects. In these activities the Core maximizes communication across all project components to further the understanding of data to be analyzed, statistical procedures for those analyses, and appropriate interpretation of findings. This Core continues to develop and implement data management strategies to process and document all data collected in Core B (Animal Resource) and in the Projects. Through its data management activities the Core will continue to build an archive of data generated under this mechanism of support. Because all data are keyed to the age and cognitive status of AI and AU rats, and each subject has a unique identifier that links subject data across datasets, many opportunities exist for comparison of data in this animal model across studies and projects. These archives serve all members of the investigative group and constitute a highly valuable base of information in the area of neurocognitive aging. Specific personnel in Core C are tasked with the database resource development and data management. Large archives of data (e.g. behavioral data and health records from the Animal Resource, microarray datasets in basal and experimental conditions) are managed in an accessible format for internal use and for data sharing both within the Program Project and with outside investigators, the latter under the supervision of Core A.