Older Americans Independence Center

总体：项目摘要 这是约翰霍普金斯大学老年美国人独立中心（JHU）的更新申请 审计和调查处）。在2018年的当前周期中，该OAIC取得了广泛的成就，有助于 150份出版物和研究结果促进了35项额外赠款的资助，重点是虚弱和老龄化。 本OAIC的研究人员寻求通过研究病因学来促进老年人的独立， 虚弱的临床后果，并通过将这些知识转化为小说的发展， 以虚弱为重点的诊断、治疗和预防策略。本提案的具体目标是实现这些目标 目标是：1）刺激和开发有效的以脆弱性为重点的跨学科研究项目; 2）翻译 将以脆弱为重点的知识转化为有针对性的预防和治疗策略， 成年人保持独立; 3）提供有针对性的和可访问的与脆弱有关的培训和指导， 对发展旨在保持老年人独立性的职业感兴趣的初级研究人员; 4） 向审调处支助的调查员提供最高质量的跨学科专门知识和基础设施， 生物统计学、生物学和临床科学- 支持开发创新方法、研究战略和技术， 脆弱性研究;和6）吸引优秀的调查人员和学员从JHU和 在当地和全国范围内提高其科学的知名度。研究教育部分和试点/ 探索性研究核心将为研究提供培训，指导以及咨询和物质支持 项目支持调查员。高度集成的资源核心集中在生物统计学，生物 机制、临床翻译/招募和技术评估/解决方案将提供支持 具有跨学科专业知识的调查员，培训，指导，援助和必要的服务， 执行突出的弱点为重点的基础，临床和转化研究。的领导和 行政核心将提供科学的愿景，行政和监管监督，并将指导 通过我们的脆弱科学网站，社交媒体，创新的教育， 倡议，嵌入OAIC网络，与科学和专业组织建立伙伴关系， 形成实践社区和外联工作。编织在整个是一个强化的重点 关于健康公平。这个OAIC将继续由一个长期的，跨学科的，有成就的， 高度可见的领导团队，他们将为下一代脆弱科学制定持续的愿景， 致力于建立一个科学和文化多样性的学者和实习生社区。 该团队致力于开发下一代所需的科学进步， 从而将战略转化为实践和政策，扩大数百万老年人的独立性，改善他们的健康状况。 成年人了

Overall: Project Summary This is a renewal application for the Johns Hopkins University Older Americans Independence Center (JHU OAIC). In the current cycle dating to 2018, this OAIC has nurtured extensive accomplishment, contributing to 150 publications and findings that facilitated the funding of 35 additional grants focused on frailty and aging. Investigators in this OAIC seek to promote independence in older adults through the study of the etiologies and clinical ramifications of frailty and through the translation of this knowledge into the development of novel, frailty-focused diagnostic, treatment, and prevention strategies. This proposal’s specific aims to achieve these goals are: 1) Stimulate and develop effective frailty-focused interdisciplinary research programs; 2) Translate the frailty-focused knowledge generated into targeted prevention and treatment strategies that help older adults maintain independence; 3) Provide focused and accessible frailty-related training and mentorship to junior investigators interested in developing careers aiming to maintain independence in older adults; 4) Provide to OAIC-supported investigators the highest quality inter-disciplinary expertise and infrastructure in biostatistical, biological, and clinical science—and, new to this cycle, also in engineering and technology; 5) Support the development of innovative methodologies, research strategies and technologies essential to the study of frailty; and 6) Attract outstanding investigators and trainees to frailty research from across JHU and promote visibility of their science locally and nationally. A Research Education Component and Pilot / Exploratory Studies Core will provide training, mentorship, and both advisory and material support for research projects for supported investigators. Highly integrated resource cores focused on biostatistics, biological mechanisms, clinical translation / recruitment, and technological assessment / solutions will provide supported investigators with the interdisciplinary expertise, training, mentorship, assistance, and services necessary to perform outstanding frailty-focused basic, clinical and translational research. The Leadership and Administration Core will provide scientific visioning, administrative and regulatory oversight, and will also guide the dissemination of frailty research through our frailty science website, social media, innovative educational initiatives, embedding in the OAIC network, partnerships with scientific and professional organizations, formation of communities of practice, and outreach efforts. Woven throughout the whole is an intensified focus on health equity. This OAIC will continue to be directed by a long-standing, interdisciplinary, accomplished, and highly visible leadership team who will develop an ongoing vision for the next generation of frailty science and have worked to build a scientifically and culturally diverse community of scholars and trainees around frailty. This team is dedicated to developing the next generation of needed scientific advances and disseminating resulting strategies into practice and policy that extend independence and improve health for millions of older adults.