Biostatistics Core-RC-1

RC1--生物统计核心；项目摘要 自2003年年中以来，OAIC生物统计核心(RC1)将急需的资源专门用于 脆弱性研究的量化挑战。与OAIC领导层结成伙伴关系，并与其他 OAIC资源核心，它帮助发展了一批跨学科的初级教员的职业生涯 由研究教育部分(REC)支持--以及更多--并确保专家设计和 对推进脆弱性科学所需的先导、外部和从头研究进行分析。它现在提议 继续这些努力，通过提供：(1)由我们的REC支持的初级教师的指导，以及我们的 更广泛的OAIC，在发展专注于脆弱和老化的职业方面；(2)新数据和计算基础设施 和软件，包括基于网络的数据存储和获取工具；(3)关于脆弱性的科学专门知识， 通过支持研究项目的设计、统计分析和数据管理，并通过 提供新的数据分析方法，这对研究复杂的综合症是必不可少的 脆弱；以及(4)在约翰斯与脆弱相关的科学和健康促进努力的领导力和知名度 霍普金斯大学，整个OAIC网络，以及更广泛的老年学社区。我们的支持和 在这些领域的领导是重要和广泛的，如果没有 这个核心的资源。领导层经验丰富，是专家，沉浸在老龄化的学术研究中，而且 在老年学和统计学中都可见。核心将继续支持每个REC和试点支持 根据他们的需要选择调查员。为了加强调查人员的培训，它提出了新的和加强的教育 以及为此目的而开展的智力丰富模式和活动，包括在线教育资源。一些人 这些资源都是为通过我们的新的信息传播核心而设计的 OAIC。核心与其他OAIC资源核心积极协同，过去一年的进展证明了这一点 周期：在当前周期中，我们增加了一名统计基因组学专家，以便更高效地工作 与生物机制核心(RC2)合作，我们将继续提供设计和分析专业知识 并支持与临床翻译和招聘核心(RC3)合作的注册中心。关于 新的方法论：研究将开发所需的方法，以更好地(I)阐明脆弱的根本原因 以及(Ii)衡量脆弱性，从而及早识别高危人群，以便成功干预。通过努力 沿着所有这些思路，这一核心将对这次OAIC在回答下一次 产生关于脆弱的问题，并实现研究结果的转化，以提高老年人的独立性 人。

RC1 – Biostatistics Core; Project Summary Since mid-2003, this OAIC Biostatistics Core (RC1) has dedicated critically needed resources toward the quantitative challenges of research on frailty. Partnering in OAIC leadership, and working closely with other OAIC resource cores, it has helped develop the careers of an interdisciplinary cohort of junior faculty supported by the Research Education Component (REC)--and beyond--and ensured expert design and analysis of pilot, external, and de novo studies needed to advance science on frailty. It now proposes to continue in these efforts, by providing: (1) mentorship for junior faculty supported by our REC, and our broader OAIC, in developing careers focused on frailty and aging; (2) new data and computing infrastructure and software, including web-based data housing and acquisition tools; (3) expertise for science on frailty, through support for the design, statistical analysis, and data management of research projects, and through making available new data analytic methodologies that are essential to studying the complex syndrome of frailty; and (4) leadership and visibility for frailty-related scientific and health promotion endeavors at Johns Hopkins, throughout the OAIC network, and in the broader gerontological community. Our support and leadership in these areas have been significant and wide-reaching, and could not be provided without the resources of this Core. The leadership is experienced, expert, deeply immersed in scholarship on aging, and visible in both gerontology and statistics. The Core will continue to support every REC and pilot-supported investigator as per their need. To enhance investigator training, it proposes new and enhanced educational and intellectual enrichment modalities and activities to this end, including online education resources. Some of these resources are designed for dissemination through the new Information Dissemination Core of our OAIC. The Core synergizes actively with other OAIC resource cores, as evidenced by progress over the last cycle: In the current cycle we have added a statistical genomics expert so as to work even more productively with the Biological Mechanisms Core (RC2), and we will continue to provide design and analytic expertise and support a Registry collaboratively with the Clinical Translation and Recruitment Core (RC3). Regarding new methodologies: research will develop approaches needed to better (i) elucidate etiology underlying frailty and (ii) measure pre-frailty, hence identify at-risk persons early enough to intervene successfully. By efforts along all these lines, this Core will contribute crucially to the success of this OAIC in answering a next generation of questions on frailty, and achieving findings' translation toward increased independence of older persons.