Katanin p80 is a key regulator of microtubule dynamics and male fertility.

男性生育是一个复杂的过程，需要数千种基因产物的协同激活。因此，15名澳大利亚男性中就有1人不育也就不足为奇了。这个项目将探索精子产生的基本途径，特别是与精子形状和活力有关的途径。这项工作可能最终会对男性不育的诊断和治疗产生影响，也可能对病理组织中类似的细胞结构产生影响。

Male fertility is a complex process requiring the co-ordinated activation of thousands of gene products. It is not surprising therefore that 1 in 15 Australian men are infertile. This project will explore an essential pathways for sperm production, specifically related to sperm shaping and motility. This work may ultimately have implications for the diagnosis and treatment of male infertility, but also for pathology in tissues will similar cellular structures.