Katanin p80 is a key regulator of microtubule dynamics and male fertility.

Katanin p80 是微管动力学和男性生育力的关键调节因子。

• 批准号: nhmrc : 1020753
• 负责人: Dr Liza O'Donnell
• 金额: $ 40.26万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/katanin-p80-key-male-fertility/110062
• 关键词: Katanin; p80; key; regulator; microtubule

Male fertility is a complex process requiring the co-ordinated activation of thousands of gene products. It is not surprising therefore that 1 in 15 Australian men are infertile. This project will explore an essential pathways for sperm production, specifically related to sperm shaping and motility. This work may ultimately have implications for the diagnosis and treatment of male infertility, but also for pathology in tissues will similar cellular structures.

男性的生育能力是一个复杂的过程，需要数千种基因产物的协同激活。因此，每15名澳大利亚男性中就有1人不育也就不足为奇了。该项目将探索精子产生的基本途径，特别是与精子成形和运动有关的途径。这项工作最终可能对男性不育症的诊断和治疗产生影响，而且对组织中类似细胞结构的病理也有影响。