Ultra Compact Polarizer Probe for Imaging Metabolism

用于代谢成像的超紧凑型偏光探头

• 批准号: 8708168
• 负责人: Kevin Wayne Waddell
• 金额: $ 19.63万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8708168
• 关键词: Adopted; Aliquot; Anesthesia procedures; Animals; Biochemical; Biochemistry; Biological Markers; Biomedical Research; Bioreactors; Carbon; Chemicals; Chemistry; Chronic; Clinical; Clinical Research; Clinical Trials; Communities; Complex; Contrast Media; Devices; Diagnosis; Electronics; Ensure; Equilibrium; Equipment; Feedback; Filtration; Gluconeogenesis; Health; Human; Image; Imaging technology; Improve Access; Institutes; Investments; Life; Logic; Magnetic Resonance; Magnetic Resonance Imaging; Malignant Neoplasms; Maps; Measures; Medical Imaging; Metabolic; Metabolic Pathway; Metabolism; Neurons; Organ; Organism; Pathology; Pathway interactions; Physiologic pulse; Positioning Attribute; Process; Production; Property; Proteomics; Public Health; Reaction; Research; Research Personnel; Safety; Science; Site; System; Technology; Testing; Time; Tissues; Training; Translating; base; cancer therapy; cellular imaging; chemical reaction; design; experience; heart metabolism; imaging probe; improved; in vivo; instrument; instrumentation; metabolic abnormality assessment; operation; pre-clinical; pre-clinical research; preclinical study; programs; prototype; public health relevance; response; tool; treatment response; tumor metabolism

DESCRIPTION (provided by applicant): Hyperpolarized magnetic resonance (HP-MR) is emerging as a technology uniquely suited for rapidly assessing pathway-specific metabolic flux in living tissue. Complex transient and chronic adaptations in cellular biochemistry form the basis of sustained energetic balance in organisms, and therefore the ability to measure perturbations of these metabolic pathways has the potential to diagnose broadly underlying pathology and quantitatively assess the response to therapy. The potential and safety of HP-MR has been sufficiently well established through preclinical studies that the technology is featured in a human clinical trial. Unfortunately, the expense, bulk, and complexity of current instruments preclude access of this technology to the majority of clinicians and biomedical researchers. This proposal aims to bridge the critical gap between potential public health impact and access of the underlying technology to the clinicians and biomedical researchers. To accomplish this, an ultra-compact and inexpensive hyperpolarization instrument will be developed that would be compatible for use with all existing (wide bore) human and preclinical MR imaging consoles. In Aim 1, we will develop a nonmagnetic, remotely controlled chemical reactor module for parahydrogen based hyperpolarization. In Aim 2, we will develop compact electronic controllers for synchronizing chemical reaction, spin transformations, and post reaction filtering. Compatibility with existing instruments is paramount to a primary objective of this proposal to ensure wide access of the HP-MR technology to clinicians and biomedical researchers. Moreover, the efficiency of the parahydrogen based technology being pursued here is tailored to the symmetry properties of the metabolic contrast agent spin systems, with higher fields expected to differentially outperform as the spin system becomes more symmetric. In Aim 3, we therefore utilize the diverse MR platforms available from the Vanderbilt Institute of Imaging Science to validate the compatibility of the instrument by interfacing the proposed polarizer instrument and imaging hyperpolarized contrast agent production, on a variety of clinical and preclinical research scanners at several field strengths and configurations.

描述（由申请人提供）：超极化磁共振（HP-MR）是一种新兴的技术，独特地适用于快速评估活组织中的通路特异性代谢通量。细胞生物化学中复杂的瞬时和慢性适应形成了生物体中持续能量平衡的基础，因此测量这些代谢途径的扰动的能力具有广泛诊断潜在病理和定量评估对治疗的反应的潜力。通过临床前研究，已充分确立了HP-MR的潜力和安全性，该技术在人体临床试验中具有特色。不幸的是，目前的仪器的费用，体积和复杂性排除了大多数临床医生和生物医学研究人员使用这项技术。该提案旨在弥合潜在的公共卫生影响与临床医生和生物医学研究人员获得基础技术之间的关键差距。为了实现这一目标，将开发一种超紧凑且廉价的超极化仪器，该仪器将与所有现有的（宽口径）人体和临床前MR成像控制台兼容。在目标1中，我们将开发一种可远程控制的化学反应器模块，用于仲氢超极化。在目标2中，我们将开发用于同步化学反应、自旋变换和反应后过滤的紧凑型电子控制器。与现有仪器的兼容性对于本提案的主要目标至关重要，以确保临床医生和生物医学研究人员广泛使用HP-MR技术。此外，这里所追求的基于仲氢的技术的效率是针对代谢造影剂自旋系统的对称性而定制的，随着自旋系统变得更加对称，预期更高的场会有差别地优于其他场。因此，在目标3中，我们利用范德比尔特成像科学研究所提供的各种MR平台，通过在多种场强和配置下的各种临床和临床前研究扫描仪上连接申报的偏振器仪器和成像超偏振造影剂生产，来验证仪器的兼容性。