Center for Human Health and the Environment

人类健康与环境中心

• 批准号: 8841236
• 负责人: Robert C Smart
• 金额: $ 109.38万
• 依托单位: NORTH CAROLINA STATE UNIVERSITY RALEIGH
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-20 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8841236
• 关键词: Address; Animal Model; Back; Basic Science; Big Data; Bioinformatics; Biological; Biology; Cells; Centers for Population Health; Clinical; Communities; Community Outreach; Core Facility; Databases; Development; Development Plans; Discipline; Disease; Ensure; Environment; Environmental Exposure; Environmental Health; Environmental Risk Factor; Epidemiology; Fostering; Funding; Future; Gap Junctions; Genes; Genome; Genomics; Goals; Grant; Health; Health Facility Environment; Health Sciences; Human; Individual; Interdisciplinary Study; Invertebrates; Knowledge; Leadership; Link; Molecular; Molecular Genetics; National Institute of Environmental Health Sciences; North Carolina; Organ Model; Outcome; Pathologic; Pathway interactions; Pilot Projects; Population; Population Sciences; Productivity; Proteomics; Public Health; Research; Research Personnel; Resources; Scientist; Services; Staging; System; Systems Biology; Technology; Tissues; Toxicogenomics; Training; Translating; Translational Research; Universities; Veterinary Pathology; Vision; base; career development; comparative; computerized tools; environmental stressor; epigenome; epigenomics; fundamental research; health science research; human disease; improved; instrumentation; laser capture microdissection; member; metabolomics; multidisciplinary; novel; prevent; programs; public health relevance; ranpirnase; research study; skills; success

 DESCRIPTION (provided by applicant) Through the purposeful interfacing of different disciplines and a systems biology framework integrating all levels of biological organization: biomolecule, pathway, cell, tissue, organ, model organism, human, and human population, the Center for Health and the Environment (CHHE) will elucidate fundamental mechanisms through which environmental stressors interface with pathways, the genome and epigenome to influence human health outcomes. CHHE will develop three interdisciplinary Research Teams that will integrate and build on NC State's unique research strengths and resources in quantitative biology and diverse model organisms as well as its emerging strength in human population science to advance discovery in environmental health sciences (EHS) along the continuum from genes to populations. The Molecular/Cellular-Based Systems and Model Organisms Team will utilize cutting-edge genetic/molecular/cellular-based systems and powerful vertebrate and invertebrate model organisms to conduct fundamental research to define mechanisms by which environmental exposures promote disease. The Human Population Science Team is composed of experts on environmental exposures, epidemiology, genomics, and epigenomics who are poised to identify key human pathways and link exposure and disease across populations. The Bioinformatics Team will develop novel computational tools and analytics to translate Big Data generated across high-throughput and multi-scale experiments into systems-level discoveries. The CHHE will develop three Facility Cores that will significantly increase the impact and the basic science and translational capacity of its Research Teams. One CHHE Facility Core will provide cutting-edge technologies involving proteomics, metabolomics and genomics along with dedicated bioinformatics support. A second Core will provide pathologic phenotypic assessment of the many model organisms used by CHHE members and provide laser capture microdissection service with links back to the "omics" technologies. The third Core, the Integrative Health Science Facility Core, will enable CHHE investigators to translate basic science discoveries to clinical and public health outcomes and vice versa. As a land-grant University, NC State has an extensive and active Cooperative Extension Service network throughout North Carolina. The CHHE will utilize this unique network to develop a highly effective, multi-directional Community Outreach and Engagement Core to disseminate findings and receive community input that will contribute to addressing disparities in exposures and health outcomes and to educate communities about environmental influences on health. A strong Career Development Core for early stage scientists that is coordinated with a robust Pilot Project Program will support cutting edge, collaborative, and multidisciplinary EHS projects to enhance the research success and impact of our membership. Through these activities and the interfacing of different disciplines, CHHE will build on NC State's unique research and community outreach strengths to become a premier transformative and synergistic EHS Core Center.

 描述（由申请人提供） 通过不同学科的有目的的接口和系统生物学框架，整合了生物组织的所有层次：生物分子，途径，细胞，组织，器官，模型 生物，人类和人类群体，健康与环境中心（CHHE）将阐明环境压力与途径，基因组和表观基因组相互作用的基本机制，以影响人类健康结果。CHHE将开发三个跨学科的研究团队，将整合和建立在北卡罗来纳州的独特的研究优势和资源，在定量生物学和不同的模式生物，以及其在人口科学的新兴力量，以推进发现环境健康科学（EHS）沿着从基因到人口的连续体。分子/细胞为基础的系统和模式生物团队将利用尖端的遗传/分子/细胞为基础的系统和强大的脊椎动物和无脊椎动物模式生物进行基础研究，以确定环境暴露促进疾病的机制。人类人口科学团队由环境暴露、流行病学、基因组学和表观基因组学专家组成，他们准备确定关键的人类途径，并将暴露和疾病联系起来。生物信息学团队将开发新的计算工具和分析，将高通量和多规模实验产生的大数据转化为系统级发现。CHHE将开发三个设施核心，这将显着提高其研究团队的影响力和基础科学和转化能力。一个CHHE设施核心将提供尖端技术，涉及蛋白质组学，代谢组学和基因组学沿着专门的生物信息学支持。第二个核心将提供CHHE成员使用的许多模式生物的病理表型评估，并提供激光捕获显微切割服务，并与“组学”技术相联系。第三个核心是综合健康科学设施核心，将使CHHE研究人员能够将基础科学发现转化为临床和公共卫生成果，反之亦然。作为一所赠地大学，北卡罗来纳州立大学在整个北卡罗来纳州拥有广泛而活跃的合作推广服务网络。CHHE将利用这一独特的网络来开发一个高效、多方向的社区外展和参与核心，以传播研究结果并接收社区投入，这将有助于解决暴露和健康结果方面的差异，并教育社区了解环境对健康的影响。 一个强大的职业发展核心的早期阶段的科学家，是协调与一个强大的试点项目计划将支持削减 边缘，协作和多学科的EHS项目，以提高研究的成功和我们的成员的影响。通过这些活动和不同学科的接口，CHHE将建立在北卡罗来纳州独特的研究和社区外展优势，成为首屈一指的变革和协同EHS核心中心。