The role of endogenous oxytocin in adult psychosocial adjustment: main effects and interactions with serotonergic and dopaminergic modulators of social cognition

内源性催产素在成人心理社会调整中的作用：主要作用以及与社会认知的血清素能和多巴胺能调节剂的相互作用

• 批准号: 8875888
• 负责人: Nancy Koven
• 金额: $ 29.94万
• 依托单位: BATES COLLEGE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8875888
• 关键词: Address; Adult; Affect; Affective; Age; Age-associated memory impairment; Aging; Am 80; Anhedonia; Anxiety; Autistic Disorder; Behavior; Behavioral; Biological Assay; Biological Markers; Clinical; Cognition; Cognitive; Communities; Cues; Data; Decision Making; Development; Distress; Dopamine; Early identification; Elements; Emotional; Emotions; Enzyme-Linked Immunosorbent Assay; Functional disorder; General Population; Goals; Hormones; Human; Hypersensitivity; Individual; Individual Differences; Intelligence; Intervention; Knowledge; Laboratories; Liquid Chromatography; Liquid substance; Literature; Love; Maps; Measurement; Measures; Mediating; Mediator of activation protein; Mental Depression; Mental disorders; Nature; Neurosecretory Systems; Neurotransmitters; Outcome; Oxytocin; Partner in relationship; Patients; Pattern; Peptides; Perception; Peripheral; Personal Satisfaction; Personality; Personality Traits; Pharmaceutical Preparations; Pharmacologic Substance; Pilot Projects; Plasma; Population; Process; Protocols documentation; Psychology; Psychometrics; Psychopathology; Reporting; Reproduction; Research; Rewards; Risk; Role; Saliva; Sampling; Sampling Studies; Schizophrenia; Serotonin; Sex Functioning; Source; Staging; Stimulus; System; Techniques; Testing; Therapeutic Effect; Treatment Protocols; Treatment/Psychosocial Effects; Trust; Withdrawal; age effect; age related; attentional bias; behavior test; clinically relevant; cognitive process; cognitive testing; cohort; contextual factors; emotion regulation; human subject; impression; improved; interest; neurochemistry; neuropsychological; psychosocial; psychosocial adjustment; public health relevance; resilience; skills; social; social cognition; tandem mass spectrometry; trait; young adult

 DESCRIPTION (provided by applicant): Oxytocin is a neuroendocrine peptide originally known for its role in mating and reproduction and more recently popularized among scientific and lay audiences for its seemingly broad-reaching effects on social cognition. Often touted as the "love hormone", oxytocin influences how we attend to, process, and respond to emotionally- and socially-relevant stimuli, which, in turn, affects how we cooperate, trust, and communicate with others. It is therefore not surprising that clinicians have begun administering pharmaceutical oxytocin to patients with certain psychiatric disturbances, including autism, schizophrenia, and depression, with the goal to improve their emotional well-being and quality of social relationships. The fact that exogenous oxytocin shows therapeutic effects for such individuals may, however, give a false impression that oxytocin is universally beneficial for the general population. Indeed, there is an emerging literature to suggest that oxytocin administration can worsen psychosocial adjustment in healthy adults, which has led to the speculation that high oxytocin levels promote a maladaptive hypersensitivity in individuals who are already emotionally attuned. Such differential outcomes may reflect pre-existing, inter-individual differences in the endogenous oxytocin system and/or presence of trait-like contextual factors that moderate the behavioral effects of oxytocin. However, we know little about the psychosocial correlates of naturally-occurring oxytocin levels or how such levels might fluctuate across adulthood or as a function of sex. Similarly, we know little about the degree and nature of influence of other neurotransmitter systems (e.g., dopamine and serotonin) that interact with oxytocin and exert their own effects on social cognition. To address these critical gaps in knowledge, this research will use peripheral biomarker assay, neuropsychological assessment, and behavioral testing in a healthy community sample (N = 240, ages 20-80) to achieve four principle goals: (1) to characterize clinically-relevant patterns of psychosocial adjustment associated with endogenous oxytocin levels, (2) to map the developmental trajectory of oxytocin-dependent changes in psychosocial adjustment across stages of adulthood, (3) to test the moderating influence of specific cognitive and affective traits on oxytocin-mediated social cognitive processes, and (4) to validate 2-D liquid chromatography-tandem mass spectrometry as an ultra-sensitive technique for quantifying oxytocin level in human saliva. This new knowledge will aid our understanding of how oxytocin influences resilience toward psychosocial distress and provide much needed biomarker norms to assist practitioners in the optimization of oxytocin manipulation.

 描述（由申请人提供）：催产素是一种神经内分泌肽，最初因其在交配和生殖中的作用而闻名，最近因其对社会认知的看似广泛的影响而在科学和非专业观众中流行。催产素通常被吹捧为“爱情荷尔蒙”，它影响我们如何关注，处理和回应情感和社会相关的刺激，这反过来又影响我们如何与他人合作，信任和沟通。因此，毫不奇怪，临床医生已经开始给患有某些精神障碍的患者服用药物催产素，包括自闭症，精神分裂症和抑郁症，目的是改善他们的情绪健康和社会关系质量。然而，外源性催产素对这些人显示出治疗效果的事实可能给人一种错误的印象，即催产素对一般人群普遍有益。事实上，有一个新兴的文献表明，催产素管理可以恶化健康成年人的心理社会调整，这导致了推测，高催产素水平促进了已经情绪协调的个体的适应不良超敏反应。这种不同的结果可能反映了内源性催产素系统中预先存在的个体间差异和/或调节催产素行为影响的特质样背景因素的存在。然而，我们对自然产生的催产素水平的心理社会相关性知之甚少，也不知道这种水平在成年期或作为性的函数如何波动。同样，我们对其他神经递质系统的影响程度和性质知之甚少（例如，多巴胺和5-羟色胺）与催产素相互作用，并对社会认知产生影响。为了解决这些知识的关键差距，本研究将在健康社区样本中使用外周生物标志物测定，神经心理学评估和行为测试（N = 240，年龄20-80），以实现四个主要目标：（1）表征与内源性催产素水平相关的心理社会调节的临床相关模式，（2）绘制成年各阶段心理社会调整中催产素依赖性变化的发展轨迹，（3）测试特定认知和情感特征对催产素介导的社会认知过程的调节影响，（4）验证二维液相色谱-串联质谱法作为一种超灵敏技术用于定量人唾液中催产素水平。这些新知识将有助于我们了解催产素如何影响对心理社会困扰的恢复力，并提供急需的生物标志物规范，以帮助从业者优化催产素操作。