Dyadic Study of Depression and Inflammation in Cancer Patients and Caregivers

癌症患者和护理人员抑郁和炎症的二元研究

基本信息

  • 批准号:
    8905160
  • 负责人:
  • 金额:
    $ 2.1万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-05-16 至 2015-06-30
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): Both cancer patients and their family caregivers are at risk for developing chronic diseases earlier and more frequently than those who have not been affected by cancer.1, 2 With the numbers of cancer survivors rising, health decline in this population becomes a substantial concern to both affected families and to society. Elevated inflammation is one potent marker of chronic disease development in both cancer survivors and their family caregivers.22,24,28-33 Thus, identifying risk factors for elevated inflammation in cancer patients and caregivers will provide targets for assessment and intervention to improve cancer patient and caregiver long- term health and reduce their risk for premature frailty and mortality. Depression is a known predictor of proinflammatory markers in both cancer patients36,37 and healthy persons.38- 40 However, the association between depressive symptoms and inflammation has yet to be studied in patients and caregivers of colorectal cancer, the third most common cancer in both men and women. Additionally, it is known patients and caregivers mutually influence each other's health outcomes, but the dyadic impacts of one's depressive symptoms on the others' inflammation have yet to be studied. This proposed study will investigate the relations between depressive symptoms as a psychological risk factor for elevated proinflammatory markers interleukin (IL)-6 and C-reactive protein (CRP). These relations will be studied in colorectal cancer patients alone, their family caregivers alone, and the patients and caregivers together. Depressive symptoms will be assessed using the CES-D at two months post-diagnosis; pro- inflammatory cytokines will be measured at 11 months post-diagnosis. Actor-partner interdependence modeling will be used to analyze data from a subset of 100 patient-caregiver dyads from an ongoing funded project. Proposed training plans to achieve the study aims include gaining comprehensive knowledge in theories and analytic strategies involved in dyadic research through close didadic training by the sponsor, supplemental coursework, exposure to national behavioral medicine conferences, manuscript preparation, and presentations. This training will facilitate the applicant's career goal of independent clinical research specializing in identifying modifiable psychological risk factors for health decline in cancer patients and caregivers. As depressive symptoms can be detected through low-cost, brief screening methods and can be effectively treated, if the data from this study show promise that both patient and caregiver depressive symptoms at diagnosis have direct, long-term immunological consequences for themselves and their partners, findings would offer a novel, cost-efficient primary and tertiary chronic disease prevention target.
 描述(由申请人提供):癌症患者及其家庭照顾者都有可能比未受癌症影响的患者更早、更频繁地患上慢性病。1,2随着癌症幸存者人数的增加,这一人群的健康状况下降成为受影响家庭和社会的重大关切。炎症升高是癌症幸存者及其家庭成员慢性疾病发展的一个有效标志物。22,24,28 -33因此,确定癌症患者和护理人员炎症升高的风险因素将为评估和干预提供目标,以改善癌症患者和护理人员的长期健康,并降低其过早虚弱和死亡的风险。抑郁症是癌症患者36、37和健康人中促炎症标志物的已知预测因子。38 - 40然而,在结直肠癌患者和护理人员中,抑郁症状和炎症之间的关联尚未得到研究,结直肠癌是男性和女性中第三常见的癌症。此外,众所周知,患者和护理人员相互影响彼此的健康结果,但一个人的抑郁症状对另一个人的炎症的双重影响还有待研究。本研究将探讨抑郁症状作为促炎标志物白细胞介素(IL)-6和C反应蛋白(CRP)升高的心理危险因素之间的关系。这些关系将在结直肠癌患者中单独研究,他们的家庭照顾者单独研究, and the patients病人and carefully护理人员together一起.将在诊断后2个月使用CES-D评估抑郁症状;将在诊断后11个月测量促炎细胞因子。演员合作伙伴的相互依存模型将被用来分析数据从一个子集的100个病人,照顾者二人组正在进行的资助项目。建议的培训计划,以实现研究目标,包括获得全面的知识,通过赞助商,补充课程,接触到国家行为医学会议,手稿准备和演示的密切教学培训的理论和分析策略参与二元研究。这项培训将促进申请人的职业目标,即专门从事确定可改变的心理风险因素的独立临床研究, 癌症患者和照顾者的健康下降。由于抑郁症状可以通过低成本,简单的筛查方法检测到,并且可以得到有效的治疗,如果这项研究的数据显示,患者和护理人员在诊断时的抑郁症状对他们自己和他们的伴侣有直接,长期的免疫后果,研究结果将提供一种新的,具有成本效益的初级和三级慢性病预防目标。

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Depressive symptoms predict cancer caregivers' physical health decline.
抑郁症状预示癌症护理人员的身体健康状况下降。
  • DOI:
    10.1002/cncr.30835
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    6.2
  • 作者:
    Shaffer,KellyM;Kim,Youngmee;Carver,CharlesS;Cannady,RachelS
  • 通讯作者:
    Cannady,RachelS
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Kelly McLean Shaffer其他文献

Kelly McLean Shaffer的其他文献

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{{ truncateString('Kelly McLean Shaffer', 18)}}的其他基金

Optimizing psychosocial intervention for breast cancer-related sexual morbidity: A factorial trial using the National Cancer Institute Community Oncology Research Program (NCORP) network
优化乳腺癌相关性发病率的心理社会干预:使用国家癌症研究所社区肿瘤学研究计划 (NCORP) 网络进行的析因试验
  • 批准号:
    10579737
  • 财政年份:
    2023
  • 资助金额:
    $ 2.1万
  • 项目类别:
Optimizing efficiency and impact of digital health interventions for caregivers: A mixed methods approach
优化护理人员数字健康干预措施的效率和影响:混合方法
  • 批准号:
    10458765
  • 财政年份:
    2021
  • 资助金额:
    $ 2.1万
  • 项目类别:
Optimizing efficiency and impact of digital health interventions for caregivers: A mixed methods approach
优化护理人员数字健康干预措施的效率和影响:混合方法
  • 批准号:
    10298118
  • 财政年份:
    2021
  • 资助金额:
    $ 2.1万
  • 项目类别:

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