The Environment-Gene Interface in Urologic Health and Disease

 描述(由申请人提供)： 这项R13提案要求资金支持最有前途的实习研究员(研究生、博士后实习生、住院医生和内科科学家实习生)获得最多30个旅行奖励，每个奖励500美元，并增加这种地位的弱势群体的代表，以参加将于11月12-15日在佛罗里达州劳德代尔堡举行的基础泌尿系统研究学会(SBUR)2015年秋季研讨会。SBUR是一个由基础和临床科学家组成的协会，专门研究正常生长和发育以及生殖道(GU)的病理情况。美国泌尿系统疾病倡议最近进行的分析表明，影响尿路的疾病在美国是一个主要的医疗负担，每年相关的医疗费用约为数百亿美元。鉴于这一负担，迫切需要更好地了解这些疾病的潜在机制，制定预防或干预战略，并确定更好的治疗方法，以提高受影响个人的生活质量。2015年秋季研讨会的主题是“泌尿系统健康和疾病中的环境-基因接口”。研讨会的具体目的是：(I)激励年轻和成熟的研究人员应用该领域的现有知识，以推动基础和转化性泌尿外科研究的前沿；(Ii)促进和推进泌尿外科研究领域的新研究人员的职业生涯；(Iii)提供一个联网、互动和建立新的 (Iv)鼓励研究人类胃肠道发育和疾病的新方法的创造性思维，从而可能导致预防或更好的治疗，从而降低与这些疾病相关的医疗成本；(V)提供一个论坛，传播与正在进行的人类胃肠道常见疾病的基础和临床研究有关的最新科学结果，这些疾病是美国和世界各地异常医疗成本的来源之一。研讨会将讨论的研究主题包括：1)泌尿系统疾病的营养方面；2)新陈代谢、代谢综合征和尿路；3)环境干扰物和泌尿系统疾病；4)性别、种族和民族：对泌尿系统疾病的影响；5)泌尿系统的炎症、感染和免疫。旅行获奖者的遴选将经过一个明确和严格的程序，抽象审查小组委员会根据提交的摘要质量对申请者进行排名，以确定最有前途的受训者。SBUR执行委员会监督奖项获得者的遴选，以确保两性和未得到充分服务的少数群体的公平代表权。如果获得资助，该项目将通过促进杰出研究生、博士后实习生、住院医生和医生-科学家实习生的参与，促进代表人数不足的少数族裔实习生参与泌尿疾病研究，从而促进研讨会的教育目标。

 DESCRIPTION (provided by applicant): This R13 proposal requests funds to support up to 30 travel awards of $500 each to the most promising trainee investigators (graduate students, postdoctoral trainees, residents and physician-scientist trainees) and to increase representation of underserved minorities of this status to attend and participate in the 2015 Fall Symposium of the Society for Basic Urologic Research (SBUR) to be held November 12th - 15th in Fort Lauderdale, FL. The SBUR is a society of basic and clinician-scientists specializing in research on normal growth and development, as well as pathological conditions of the genitourinary (GU) tract. Recent analyses conducted by the Urologic Diseases in America initiative indicates that conditions affecting the urinary tract represent a major healthcare burden in the US, with associated healthcare costs on the order of tens of billions of dollars annually. Given this burden, there is an urgent need to better understand the mechanisms underlying these diseases, develop strategies for prevention or intervention, and identify better treatments to improve quality of life for affected individuals The theme of the 2015 Fall Symposium is "The Environment-Gene Interface in Urologic Health and Disease". The specific aims of the Symposium are to: (i) Inspire young and established investigators to apply current knowledge in the field to advance the frontiers of basic and translational urologic research; (ii) Promote and advance the careers of new investigators in the field of urologic research; (iii) Provide a forum for networking, interaction, and establishing new collaborations between investigators focused in GU development and disease and those from other disciplines; (iv) Encourage creative thought on new approaches to study human GU development and disease that might lead to prevention or better therapeutics that reduce the health costs associated with these diseases and (v) Provide a forum for the dissemination of up-to-date scientific results pertaining to ongoing basic and clinical research on the common diseases of the human GU tract that are a source of extraordinary health costs in the United States and around the world. Research topics that will be covered during the Symposium include: 1) Nutritional aspects of urologic disease; 2) Metabolism, metabolic syndrome and the urinary tract; 3) Environmental disruptors and urologic disease; 4) Sex, race and ethnicity: impact on urologic disease; 5) Inflammation, infection and immunity in urology. Selection of travel awardees will proceed through a defined, rigorous process in which applicants are ranked by the Abstract Review Subcommittee based on the quality of submitted abstracts to identify the most promising trainees. The Executive Committee of the SBUR oversees selection of award recipients to ensure equitable representation of both genders and underserved minorities. If funded, this project will contribute to the educational objectives of the Symposium by promoting the participation of exceptional graduate students, postdoctoral trainees, residents and physician-scientist trainees, and enhance participation in urologic disease research by underrepresented minority trainees.