Reducing the burden of chronic inflammation through dietary integration of Moringa oleifera

通过辣木饮食减少慢性炎症的负担

• 批准号: 8816534
• 负责人: Carrie Waterman
• 金额: $ 6.77万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2016-03-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8816534
• 关键词: Adipocytes; Affect; Africa; Animals; Anti-Inflammatory Agents; Anti-inflammatory; Antioxidants; Apolipoprotein E; Appearance; Area; Atherosclerosis; Award; Biological; Blood Glucose; Botanicals; Brassicaceae; Broccoli - dietary; Cardiovascular Diseases; Cardiovascular system; Cell Line; Cholesterol; Chronic; Clinical Research; Clinical Trials; Collaborations; Communicable Diseases; Data; Developing Countries; Development; Diabetes Mellitus; Diabetic mouse; Diet; Disease; Edible Plants; Enzymes; Evaluation; Family; Fatty Liver; Fatty acid glycerol esters; Food; Fostering; Future; Glucosinolates; Goals; Grant; HIV; Harvest; Health; Hepatocyte; Human; Hyperglycemia; Inflammation; Inflammatory; Institutes; Insulin; Interleukin-1; International; Isothiocyanates; K-Series Research Career Programs; Kenya; Leptin; Link; MAP Kinase Gene; Malaria; Malignant Neoplasms; Malnutrition; Master of Science; Medical Research; Mentors; Mentorship; Metabolic; Metabolic Biotransformation; Metabolic Diseases; Metabolic Marker; Metabolic Pathway; Metabolism; Methods; Modeling; Moringa; Moringa oleifera; Mus; Muscle; Muscle Cells; Nature; Nutrient; Outcome; Pathway interactions; Patients; Peroxisome Proliferator-Activated Receptors; Phase; Phytochemical; Plant Leaves; Plants; Populations at Risk; Powder dose form; Prevention; Process; Production; Research; Research Institute; Research Personnel; Resources; Serum; Signal Pathway; Source; Sulforaphane; Supplementation; TNF gene; Technology; Therapeutic; Therapeutic Agents; Therapeutic Effect; Traditional Medicine; Trees; Triglycerides; Tuberculosis; United States National Institutes of Health; Universities; Weight; Weight Gain; analog; base; biological systems; career; career development; chemical property; cost; cost effective; cruciferous vegetable; cytokine; db/db mouse; density; diabetic cardiomyopathy; experience; global health; glucose metabolism; glucose production; improved; in vivo; inflammatory marker; macrophage; mouse model; novel strategies; physical property; pre-clinical; prevent; programs; public health relevance; research and development; skills; sound; vascular inflammation

DESCRIPTION (provided by applicant): The central goal of this IRSDA career development award is to foster my ability to become an independent global health researcher and expert in the field of therapeutic plant applications. The proposed research on the use of Moringa oleifera to treat and prevent conditions related to chronic inflammation will serve as a platform for furthering my career, including new collaborations, improved grantsmanship and ability to coordinate a diverse team of international experts. This award will build upon my sound phytochemical/ biological skills and substantial international experience to advance my career and acquire new skills in needed areas. The proposed research will have important and relevant health outcomes in Kenya and the US, build research capacity in Kenya, and establish partners for future global collaborations. In order to fulfill my career development goals I have assembled an advisory team of mentors and co-mentors from Rutgers University, the Kenya Medical Research Institute (KEMRI), and Kenyatta University. My team will help me achieve: (1) expertise in therapeutic plant production; (2) excellence in the evaluation of botanicals in biological systems; and (3) coordination of international interdisciplinary teams for integration o scientific research and global health development in impact-driven projects. Ilya Raskin will serve as my primary US-mentor, who has expertise in plant-based therapeutics, mentorship, and international collaboration. Dr. Jennifer Orwa will serve as my primary LMIC-mentor at KEMRI, where she leads the Center for Traditional Medicine Research, and has the expertise to guide my career development and research goals. All collaborating institutes are dedicated to utilizing phytochemicals in plants and foods to improve human health and are well-equipped to perform the research. Career goals 1 and 2 will bolster my technical skills, while goal 3 will overarch all aspects of my research and development. In addition I have two collaborators who will assist me in specific aims of the project, and one for my career development who will advise me through the Professional Science Masters (PSM) in Global Health degree program.

这个IRSDA职业发展奖的中心目标是培养我成为治疗性植物应用领域的独立全球健康研究人员和专家的能力。拟议中的关于使用辣木治疗和预防慢性炎症相关疾病的研究将作为促进我职业生涯的平台，包括新的合作，改善granifera和协调多元化国际专家团队的能力。这个奖项将建立在我健全的植物化学/生物学技能和丰富的国际经验，以促进我的职业生涯，并获得在所需领域的新技能。拟议的研究将在肯尼亚和美国产生重要和相关的健康成果，建立肯尼亚的研究能力，并为未来的全球合作建立合作伙伴。为了实现我的职业发展目标，我组建了一个由罗格斯大学，肯尼亚医学研究所（KEMRI）和肯雅塔大学的导师和共同导师组成的顾问团队。我的团队将帮助我实现：（1）在治疗植物生产方面的专业知识;（2）在生物系统中的植物药评估方面的卓越表现;以及（3）在影响驱动的项目中协调国际跨学科团队整合科学研究和全球健康发展。伊利亚·拉斯金（Ilya Raskin）将担任我的主要美国导师，他在植物疗法、指导和国际合作方面拥有专业知识。Jennifer Orwa博士将担任我在KEMRI的主要LMIC导师，在那里她领导传统医学研究中心，并拥有指导我的职业发展和研究目标的专业知识。所有合作机构都致力于利用植物和食品中的植物化学物质来改善人类健康，并配备了良好的研究设备。职业目标1和2将提高我的技术技能，而目标3将覆盖我研究和开发的所有方面。此外，我有两个合作者谁将协助我在项目的具体目标，和我的职业发展谁将建议我通过专业科学硕士（PSM）在全球健康学位课程。