Reducing the burden of chronic inflammation through dietary integration of Moringa oleifera

通过辣木饮食减少慢性炎症的负担

基本信息

批准号：
8816534
负责人：
Carrie Waterman
金额：
$ 6.77万
依托单位：
RUTGERS, THE STATE UNIV OF N.J.
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-01 至 2016-03-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8816534
关键词：
Adipocytes Affect Africa Animals Anti-Inflammatory Agents Anti-inflammatory Antioxidants Apolipoprotein E Appearance Area Atherosclerosis Award Biological Blood Glucose Botanicals Brassicaceae Broccoli - dietary Cardiovascular Diseases Cardiovascular system Cell Line Cholesterol Chronic Clinical Research Clinical Trials Collaborations Communicable Diseases Data Developing Countries Development Diabetes Mellitus Diabetic mouse Diet Disease Edible Plants Enzymes Evaluation Family Fatty Liver Fatty acid glycerol esters Food Fostering Future Glucosinolates Goals Grant HIV Harvest Health Hepatocyte Human Hyperglycemia Inflammation Inflammatory Institutes Insulin Interleukin-1 International Isothiocyanates K-Series Research Career Programs Kenya Leptin Link MAP Kinase Gene Malaria Malignant Neoplasms Malnutrition Master of Science Medical Research Mentors Mentorship Metabolic Metabolic Biotransformation Metabolic Diseases Metabolic Marker Metabolic Pathway Metabolism Methods Modeling Moringa Moringa oleifera Mus Muscle Muscle Cells Nature Nutrient Outcome Pathway interactions Patients Peroxisome Proliferator-Activated Receptors Phase Phytochemical Plant Leaves Plants Populations at Risk Powder dose form Prevention Process Production Research Research Institute Research Personnel Resources Serum Signal Pathway Source Sulforaphane Supplementation TNF gene Technology Therapeutic Therapeutic Agents Therapeutic Effect Traditional Medicine Trees Triglycerides Tuberculosis United States National Institutes of Health Universities Weight Weight Gain analog base biological systems career career development chemical property cost cost effective cruciferous vegetable cytokine db/db mouse density diabetic cardiomyopathy experience global health glucose metabolism glucose production improved in vivo inflammatory marker macrophage mouse model novel strategies physical property pre-clinical prevent programs public health relevance research and development skills sound vascular inflammation

项目摘要

DESCRIPTION (provided by applicant): The central goal of this IRSDA career development award is to foster my ability to become an independent global health researcher and expert in the field of therapeutic plant applications. The proposed research on the use of Moringa oleifera to treat and prevent conditions related to chronic inflammation will serve as a platform for furthering my career, including new collaborations, improved grantsmanship and ability to coordinate a diverse team of international experts. This award will build upon my sound phytochemical/ biological skills and substantial international experience to advance my career and acquire new skills in needed areas. The proposed research will have important and relevant health outcomes in Kenya and the US, build research capacity in Kenya, and establish partners for future global collaborations. In order to fulfill my career development goals I have assembled an advisory team of mentors and co-mentors from Rutgers University, the Kenya Medical Research Institute (KEMRI), and Kenyatta University. My team will help me achieve: (1) expertise in therapeutic plant production; (2) excellence in the evaluation of botanicals in biological systems; and (3) coordination of international interdisciplinary teams for integration o scientific research and global health development in impact-driven projects. Ilya Raskin will serve as my primary US-mentor, who has expertise in plant-based therapeutics, mentorship, and international collaboration. Dr. Jennifer Orwa will serve as my primary LMIC-mentor at KEMRI, where she leads the Center for Traditional Medicine Research, and has the expertise to guide my career development and research goals. All collaborating institutes are dedicated to utilizing phytochemicals in plants and foods to improve human health and are well-equipped to perform the research. Career goals 1 and 2 will bolster my technical skills, while goal 3 will overarch all aspects of my research and development. In addition I have two collaborators who will assist me in specific aims of the project, and one for my career development who will advise me through the Professional Science Masters (PSM) in Global Health degree program.

描述（由申请人提供）：该IRSDA职业发展奖的核心目标是培养我成为治疗植物应用领域的独立全球健康研究员和专家的能力。提议的关于使用Moringa oleifera来治疗和预防与慢性炎症有关的条件的研究将成为促进我职业生涯的平台，包括新的合作，改善了赠款技巧以及协调多样化的国际专家团队的能力。该奖项将以我声音的植物化学/生物学技能和丰富的国际经验为基础，以提高我的职业生涯并在所需领域获得新技能。拟议的研究将在肯尼亚和美国具有重要的和相关的健康成果，在肯尼亚建立研究能力，并为未来的全球合作建立合作伙伴。为了实现我的职业发展目标，我已经组建了罗格斯大学，肯尼亚医学研究所（Kemri）和肯雅塔大学的导师和联合顾问咨询团队。我的团队将帮助我实现：（1）治疗植物生产方面的专业知识；（2）在生物系统中评估植物性的卓越；（3）国际跨学科团队的融合o科学研究和影响驱动的项目的全球健康发展。伊利亚·拉斯金（Ilya Raskin）将担任我的主要美国委员会，他在基于植物的治疗，指导和国际合作方面拥有专业知识。 Jennifer Orwa博士将在Kemri担任我的主要LMIC-Mentor，在那里她领导传统医学研究中心，并具有指导我的职业发展和研究目标的专业知识。所有合作的机构都致力于利用植物和食品中的植物化学物质来改善人类健康，并能够良好地进行研究。职业目标1和2将增强我的技术技能，而目标3将涵盖我的研发的所有方面。此外，我还有两个合作者，他们将协助我实现该项目的特定目标，一个为我的职业发展提供了帮助，他们将通过全球健康学位课程的专业科学硕士（PSM）为我提供建议。