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Fatty Acids & Risk of Dengue Hemorrhagic Fever

脂肪酸

基本信息

批准号：
8796151
负责人：
EDUARDO VILLAMOR
金额：
$ 19.72万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-02-01 至 2017-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8796151
关键词：
Acute Ambulatory Health Center Anti-Inflammatory Agents Anti-inflammatory Antigen Presentation Antiviral Agents Arachidonic Acids Area Cell membrane Cells Chemicals Cities Cohort Studies Colombia Complement Factor B Country Data Dendritic Cells Dengue Dengue Hemorrhagic Fever Dengue Shock Syndrome Development Diagnosis Diet Dietary intake Disease Docosahexaenoic Acids Eicosapentaenoic Acid Exhibits Fatty Acids Fever Fish Oils Fishes Foundations Functional disorder Health Hour Immune Immunity Incidence Infection Inflammation Inflammatory Investigation Life Linolenic Acids Lipids Major Histocompatibility Complex Malnutrition Measures Membrane Microdomains Metabolic Mononuclear N-3 polyunsaturated fatty acid Nuclear Nutrient Nutritional Nutritional status Outcome Pathway interactions Patients Persons Play Polyunsaturated Fatty Acids Population Prevention Production Property Prospective Studies Risk Role Sampling Serum Supplementation Surface T-Lymphocyte Testing Time base cohort cytokine follow-up macrophage metropolitan neutrophil prevent prospective transcription factor virucide

项目摘要

DESCRIPTION (provided by applicant): The nutritional status is a strong predictor of the risk and outcome of infections. Dengue infection is highly endemic in populations that are subject to nutritional deficiencies; yet little is known regarding the role that those deficiencies could playon the progression from dengue fever to life-threatening forms of dengue, including dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS). Fatty acids obtained from diet play a significant role as modulators of immunity and inflammation. N-3 polyunsaturated fatty acids (PUFA) from fish exhibit potent anti-inflammatory and inflammation-resolving properties through the actions of resolvins, metabolic products that act on neutrophils, macrophages, dendritic cells, and T cells. N-3 PUFA also decrease mononuclear cell production of pro-inflammatory cytokines by modifying the activity of nuclear transcription factor B. Some n-6 fatty acids exhibit antiviral activity. In addition, incorporation of PUFA into immune cell membrane microdomains modulates MHC surface expression and antigen presentation activity. Several of these mechanisms may be involved in the pathophysiology of DHF/DSS but the potential role of fatty acids on progression to severe manifestations of dengue infection is unknown. In this study we examine the associations of serum n-3 and n-6 fatty acid concentrations among patients diagnosed with dengue fever (DF) and their risk of developing DHF/DSS. We will conduct a prospective investigation in the context of a cohort of patients diagnosed with DF at ambulatory health centers of the city of Bucaramanga, Colombia. The serum fatty acids profile at the time of DF diagnosis will be compared between 124 patients who developed DHF/DSS during follow-up of the acute episode and 504 patients who did not progress to DHF/DSS. Results of this study will provide a basis to consider the effect of supplementation with these inexpensive nutrients during treatment of acute DF to prevent progression to severe forms of the disease.

描述(由申请人提供)：营养状况是感染风险和结果的有力预测指标。登革热感染在有营养缺乏的人群中高度流行；然而，关于这些缺乏对登革热向包括登革出血热和登革休克综合征(登革出血热/登革休克综合征)在内的危及生命的形式的登革热的进展可能起到的作用知之甚少。从饮食中获得的脂肪酸在免疫和炎症中起着重要的调节作用。鱼中的N-3多不饱和脂肪酸(PUFA)通过作用于中性粒细胞、巨噬细胞、树突状细胞和T细胞的代谢产物--分解素，显示出强大的抗炎和消炎特性。N-3多不饱和脂肪酸还通过改变核转录因子B的活性来减少单个核细胞产生促炎细胞因子。抗病毒活性。此外，将多不饱和脂肪酸掺入免疫细胞膜微区可以调节MHC的表面表达和抗原呈递活性。这些机制中的几个可能与DHF/DSS的病理生理学有关，但脂肪酸在进展为严重登革热感染表现方面的潜在作用尚不清楚。在这项研究中，我们研究了诊断为登革热(DF)的患者的血清n-3和n-6脂肪酸浓度与他们发生DHF/DSS的风险之间的关系。我们将在哥伦比亚布卡拉曼加市门诊卫生中心的一组被诊断为DF的患者的背景下进行前瞻性调查。对124名在急性发作期间发生DHF/DSS的患者和504名未发展为DHF/DSS的患者在诊断DF时的血清脂肪酸分布进行比较。这项研究的结果将提供一个基础，以考虑在治疗急性DF期间补充这些廉价营养素的效果，以防止发展为严重形式的疾病。