Prenatal and Neonatal Risk Factors for Adverse Neurodevelopmental Outcomes in Childhood and Early Adulthood

宫内生活和婴儿期是大脑发育的关键敏感期。可预防的作用 产前和新生儿因素对精神和神经发育障碍的风险尚不清楚。母性 性格特征会影响怀孕、分娩和新生儿并发症的风险，而这些并发症又可能影响 神经发育过程。然而，将这些事件联系在一起的机械序列并不是 描述。利用全国登记册的联系，我们建议进行一项以人口为基础的队列研究 瑞典1983-2016年间出生的340万独生子女，以研究母亲因素与 以及妊娠、分娩和新生儿并发症，有精神和神经发育的风险 精神障碍(抑郁障碍、双相情感障碍、自杀、精神分裂症、神经性厌食症、自闭症、智力障碍 残疾、癫痫和脑瘫)。我们将寻求互补的分析方法，以加强 因果推断，包括两次怀孕之间暴露变化的研究，配对同胞病例对照 研究、完全母亲-兄弟姐妹配对病例对照研究和调解分析。瑞典全国 登记册是全世界解决这些问题的最大和最完整的数据来源。

Intrauterine life and infancy are critically sensitive periods in brain development. The role of preventable prenatal and neonatal factors on the risk of psychiatric and neurodevelopmental disorders is unclear. Maternal characteristics influence risks of pregnancy, delivery, and neonatal complications which may in turn affect neurodevelopmental processes. Nevertheless, a mechanistic sequence connecting these events has not been described. Using linkage of nation-wide registries, we propose to conduct a population-based cohort study of 3.4 million singleton children born 1983-2016 in Sweden, to examine the associations of maternal factors as well as pregnancy, delivery, and neonatal complications with the risks of psychiatric and neurodevelopmental disorders (depressive disorder, bipolar disorder, suicide, schizophrenia, anorexia nervosa, autism, intellectual disability, epilepsy, and cerebral palsy). We will pursue complementary analytic approaches to strengthen causal inference including studies of exposure change between pregnancies, matched sibling case-control studies, full mother-sibling pairs case-control studies, and mediation analyses. The Swedish nation-wide registries constitute the largest and most complete data source worldwide to address these questions.