Prenatal and Neonatal Risk Factors for Adverse Neurodevelopmental Outcomes in Childhood and Early Adulthood

胎儿期和婴儿期是大脑发育的关键敏感期。可预防的作用 产前和新生儿因素对精神和神经发育障碍的风险尚不清楚。产妇 特征影响妊娠、分娩和新生儿并发症的风险，而这些并发症又可能影响 神经发育过程然而，连接这些事件的机械序列尚未被发现。 介绍了利用全国范围内登记的联系，我们建议进行一项基于人群的队列研究， 3.4 1983年至2016年在瑞典出生的100万名独生子女，以检查母亲因素与 以及妊娠、分娩和新生儿并发症， 精神障碍（抑郁症、双相情感障碍、自杀、精神分裂症、神经性厌食症、自闭症、智力障碍） 残疾、癫痫和脑瘫）。我们将采取互补的分析方法， 因果推断，包括妊娠间暴露变化的研究，匹配的兄弟姐妹病例对照 研究，完全的母亲-兄弟姐妹对病例对照研究和中介分析。瑞典全国 登记册是全世界解决这些问题的最大和最完整的数据来源。

Intrauterine life and infancy are critically sensitive periods in brain development. The role of preventable prenatal and neonatal factors on the risk of psychiatric and neurodevelopmental disorders is unclear. Maternal characteristics influence risks of pregnancy, delivery, and neonatal complications which may in turn affect neurodevelopmental processes. Nevertheless, a mechanistic sequence connecting these events has not been described. Using linkage of nation-wide registries, we propose to conduct a population-based cohort study of 3.4 million singleton children born 1983-2016 in Sweden, to examine the associations of maternal factors as well as pregnancy, delivery, and neonatal complications with the risks of psychiatric and neurodevelopmental disorders (depressive disorder, bipolar disorder, suicide, schizophrenia, anorexia nervosa, autism, intellectual disability, epilepsy, and cerebral palsy). We will pursue complementary analytic approaches to strengthen causal inference including studies of exposure change between pregnancies, matched sibling case-control studies, full mother-sibling pairs case-control studies, and mediation analyses. The Swedish nation-wide registries constitute the largest and most complete data source worldwide to address these questions.