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Prenatal and Neonatal Risk Factors for Adverse Neurodevelopmental Outcomes in Childhood and Early Adulthood

Prenatal and Neonatal Risk Factors for Adverse Neurodevelopmental Outcomes in Childhood and Early Adulthood
儿童期和成年早期不良神经发育结果的产前和新生儿危险因素
批准号:
9886282
负责人:
EDUARDO VILLAMOR
金额:
$17.44万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-03-05 至 2022-01-31

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项目成果

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中文摘要
翻译
宫内生活和婴儿期是大脑发育的关键敏感时期。可预防的作用
英文摘要
Intrauterine life and infancy are critically sensitive periods in brain development. The role of preventable prenatal and neonatal factors on the risk of psychiatric and neurodevelopmental disorders is unclear. Maternal characteristics influence risks of pregnancy, delivery, and neonatal complications which may in turn affect neurodevelopmental processes. Nevertheless, a mechanistic sequence connecting these events has not been described. Using linkage of nation-wide registries, we propose to conduct a population-based cohort study of 3.4 million singleton children born 1983-2016 in Sweden, to examine the associations of maternal factors as well as pregnancy, delivery, and neonatal complications with the risks of psychiatric and neurodevelopmental disorders (depressive disorder, bipolar disorder, suicide, schizophrenia, anorexia nervosa, autism, intellectual disability, epilepsy, and cerebral palsy). We will pursue complementary analytic approaches to strengthen causal inference including studies of exposure change between pregnancies, matched sibling case-control studies, full mother-sibling pairs case-control studies, and mediation analyses. The Swedish nation-wide registries constitute the largest and most complete data source worldwide to address these questions.
期刊论文(9)
专著(0)
科研奖励(0)
会议论文
DOI: 10.1111/dmcn.15223
发表时间: 2022-09
期刊: DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
影响因子: 3.8
作者: [Villamor, Eduardo]
通讯作者: Villamor, Eduardo
Defective Placentation Syndromes and Intellectual Disability in the Offspring: Nationwide Cohort and Sibling-Controlled Studies.
后代胎盘缺陷综合征和智力障碍:全国队列和兄弟姐妹对照研究。
DOI: 10.1093/aje/kwac068
发表时间: 2022
期刊: American journal of epidemiology
影响因子: 5
作者: [Villamor,Eduardo, Susser,EzraS, Cnattingius,Sven]
通讯作者: Cnattingius,Sven
DOI: 10.1007/s10654-022-00884-3
发表时间: 2022-08
期刊: EUROPEAN JOURNAL OF EPIDEMIOLOGY
影响因子: 13.6
作者: [Villamor, Eduardo, Susser, Ezra S., Cnattingius, Sven]
通讯作者: Cnattingius, Sven
DOI: 10.1093/ije/dyab131
发表时间: 2022-01-06
期刊: International journal of epidemiology
影响因子: 7.7
作者: [Chen R, Sjölander A, Johansson S, Lu D, Razaz N, Tedroff K, Villamor E, Cnattingius S]
通讯作者: Cnattingius S
共 6 条
    Transgenerational Effects of Maternal Obesity on Pregnancy Outcomes and Infant Health
    Fatty Acids & Risk of Dengue Hemorrhagic Fever
    Fatty Acids & Risk of Dengue Hemorrhagic Fever
    Vitamins, Breast Milk HIV Shedding and Child Health
    • 批准号:
      6949615
    • 项目类别:
    • 资助金额:
      $43.07万
    • 财政年份:
      2004
    • 负责人:
      EDUARDO VILLAMOR
    • 依托单位:
    海外基金