CMPB Central Pathology Support

CMPB 中央病理学支持

• 批准号: 9143533
• 负责人: Robert Sills
• 金额: $ 1297.31万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9143533
• 关键词: Anatomy; Atherosclerosis; Autopsy; Biological Assay; Blood; Body Fluids; Cardiovascular Diseases; Cells; Chronic; Clinical; Clinical Pathology; Collaborations; Communities; Consultations; Development; Disease; Electron Microscopy; Gene Expression; Gene Expression Regulation; Goals; Histology; Immune; Immunohistochemistry; Inflammatory; Institutes; Kidney Diseases; Laboratories; Laboratory Animals; Laboratory Research; Lasers; Lesion; Lung diseases; Malignant Neoplasms; Mediating; Medical Research; Methods; Microdissection; Molecular; Mus; National Institute of Environmental Health Sciences; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Pathogenesis; Pathologist; Pathology; Phenotype; Process; Protocols documentation; Research; Research Personnel; Retrospective Studies; Services; Skeletal Development; Technical Expertise; Techniques; Testing; Work; animal tissue; base; dietary restriction; digital imaging; neoplastic; new technology; programs; sample collection

The CMPB Pathology Core Laboratories have continued to provide critical pathology support services, collaboration and consultation for over 60 research laboratories across the Institute. Over the past year, collaborative and support oriented work has had a significant impact on a spectrum of research programs involved in the study and understanding of a variety of diseases and disease processes such as cardiovascular disease (atherosclerosis), inflammatory respiratory disease, obesity and type II diabetes, inflammatory and immune-mediated renal disease, gene expression and gene regulation, axial skeletal development, cancer and transgenerational effects of diet restriction. The volume and scope of work has increased significantly across all of the Core Laboratories, as have collaborations and consultations with scientific staff whether on a technical level regarding the methods required, or on a scientific level, requiring consultation with a staff pathologist. Core staff have worked with investigators to develop and establish specialized techniques and protocols for a variety of applications. Additionally, using materials from the DNTP subchronic (90-day) and chronic (2-year) bioassays, the Cores have been involved in retrospective studies aimed at elucidating the pathogenesis and molecular mechanisms involved in the development of variety of proliferative non-neoplastic neoplastic lesions.

CMPB病理学核心实验室继续为研究所内的60多个研究实验室提供关键病理支持服务、协作和咨询。在过去的一年里，以协作和支持为导向的工作对一系列研究项目产生了重大影响，这些项目涉及研究和了解各种疾病和疾病过程，如心血管疾病(动脉粥样硬化)、炎症性呼吸系统疾病、肥胖症和II型糖尿病、炎症和免疫介导的肾脏疾病、基因表达和基因调控、中轴骨骼发育、癌症和饮食限制的跨代影响。所有核心实验室的工作量和工作范围都大大增加，与科学工作人员的合作和磋商也大大增加，无论是在所需方法的技术层面上，还是在科学层面上，需要与工作人员病理学家进行磋商。核心工作人员与调查人员合作，为各种应用开发和建立专门的技术和协议。此外，使用dNTP亚慢性(90天)和慢性(2年)生物测定的材料，这些核心已经参与了旨在阐明各种增殖性非肿瘤性肿瘤病变的发病机制和分子机制的回顾性研究。