Tracking Achilles Tendon Compression to Monitor Insertional Achilles Tendonopathy

跟踪跟腱压缩情况以监测插入性跟腱病

基本信息

  • 批准号:
    8927531
  • 负责人:
  • 金额:
    $ 7.68万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-09-15 至 2017-08-31
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): Insertional Achilles tendinopathy (IAT) is a painful and common disorder that is difficult to treat. Standard physical therapy interventions that work well for other forms of Achilles tendinopathy are only ~50% effective for IAT, and patients who fail physical therapy require surgeries that are expensive, entail long recovery times and often lead to complications. Thus, there is a need to develop novel and effective treatments to improve clinical outcomes for IAT patients. A critical step in this process is to establish a tool or accurately monitoring the efficacy of conservative and non-conservative care. IAT is thought to be caused by compressive stress due to impingement of the tendon on the heel bone as the ankle rotates, and our preliminary studies support this theory. Thus, we hypothesize that tracking compression of the Achilles tendon against the heel as the ankle rotates is a useful tool for assessing the severity of IAT. In preliminary work, we have shown that we can quantify compression of the Achilles tendon onto the heel by analyzing ultrasound images taken while the ankle rotates. In Aim 1, we propose to apply this technique to test whether the extent of compression in IAT tendons is larger than in healthy tendons. In Aim 2, we will investigate whether the extent of compression in IAT tendons is associated with tissue-scale structural and mechanical alterations. Finally, in Aim 3 we will test whether self-reported function in IAT patients is better correlated with our ultrasound-based measurements of tendon compression than with standard clinical measures of heel geometry and muscle stiffness, two factors that may contribute to impingement of the Achilles tendon on the heel. The findings of this study will define a critical threshold for damaging compression in the Achilles tendon that will guide novel, targeted strategies designed to reverse IAT. Furthermore, the inexpensive and non- invasive tool established in this proposal will enable longitudinal monitoring of treatments for this IAT tht may help improve outcomes for IAT patients. Project Description Page 1
 描述(由申请人提供):插入性跟腱病(IAT)是一种疼痛且常见的疾病,难以治疗。对其他形式的跟腱病有效的标准物理治疗干预对IAT的有效性仅为~50%,物理治疗失败的患者需要进行昂贵的手术,需要较长的恢复时间,并且经常导致并发症。因此,需要开发新的和有效的治疗以改善IAT患者的临床结果。在这个过程中的一个关键步骤是建立一个工具或准确地监测保守和非保守治疗的疗效。IAT被认为是由于踝关节旋转时跟腱撞击跟骨造成的压缩应力引起的,我们的初步研究支持这一理论。因此,我们假设跟踪踝关节旋转时跟腱对足跟的压迫是评估IAT严重程度的有用工具。在初步的工作中,我们已经表明,我们可以量化的压缩跟腱到脚跟通过分析超声图像,而脚踝旋转。在目标1中,我们建议应用这种技术来测试IAT肌腱的压缩程度是否大于健康肌腱。在目标2中,我们将研究IAT肌腱的压缩程度是否与组织尺度的结构和力学变化相关。最后,在目标3中,我们将测试IAT患者自我报告的功能是否与我们基于超声的肌腱压缩测量值比与脚跟几何形状和肌肉僵硬度的标准临床测量值更好地相关,这两个因素可能导致跟腱撞击脚跟。这项研究的结果将定义跟腱损伤性压迫的临界阈值,这将指导旨在逆转IAT的新的、有针对性的策略。此外,该提案中建立的廉价和非侵入性工具将能够纵向监测这种IAT的治疗,这可能有助于改善IAT患者的结局。项目描述第1页

项目成果

期刊论文数量(0)
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Mark Raymond Buckley其他文献

Mark Raymond Buckley的其他文献

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{{ truncateString('Mark Raymond Buckley', 18)}}的其他基金

Modulation of Insertional Achilles Tendinopathy by Multiaxial Mechanical Strains
多轴机械应变调节插入性跟腱病
  • 批准号:
    9380380
  • 财政年份:
    2017
  • 资助金额:
    $ 7.68万
  • 项目类别:
Modulation of Insertional Achilles Tendinopathy by Multiaxial Mechanical Strains
多轴机械应变调节插入性跟腱病
  • 批准号:
    10404418
  • 财政年份:
    2017
  • 资助金额:
    $ 7.68万
  • 项目类别:
Modulation of Insertional Achilles Tendinopathy by Multiaxial Mechanical Strains
多轴机械应变调节插入性跟腱病
  • 批准号:
    10171395
  • 财政年份:
    2017
  • 资助金额:
    $ 7.68万
  • 项目类别:
Tracking Achilles Tendon Compression to Monitor Insertional Achilles Tendonopathy
跟踪跟腱压缩情况以监测插入性跟腱病
  • 批准号:
    8823271
  • 财政年份:
    2014
  • 资助金额:
    $ 7.68万
  • 项目类别:
Tracking Achilles Tendon Compression to Monitor Insertional Achilles Tendonopathy
跟踪跟腱压缩情况以监测插入性跟腱病
  • 批准号:
    9115033
  • 财政年份:
    2014
  • 资助金额:
    $ 7.68万
  • 项目类别:

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