Cognitive decline after hospitalization in older adults: predictors and pathogenesis
老年人住院后认知能力下降:预测因素和发病机制
基本信息
- 批准号:8949934
- 负责人:
- 金额:$ 11.61万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-08-15 至 2020-04-30
- 项目状态:已结题
- 来源:
- 关键词:Academic Medical CentersAccelerationAddressAdvisory CommitteesAge-associated memory impairmentAgingAlzheimer&aposs DiseaseAnesthesia proceduresApplications GrantsAreaAwardBlood VesselsCaringCerebrovascular DisordersCharacteristicsClinicClinicalClinical assessmentsCognitionCognitiveCognitive agingCommunitiesCompetenceCritical CareDataData SetDeliriumDementiaDevelopmentDiseaseElderlyElectronicsEpidemiologic MethodsEpidemiologic StudiesEpidemiologistEvaluationFoundationsFrequenciesFundingGoalsGrowthGuidelinesHeadHealthHealth PolicyHippocampus (Brain)HospitalizationHospitalsIllinoisImpaired cognitionInstitutesKnowledgeLewy BodiesLinkMagnetic Resonance ImagingMedicalMedicareMedicare claimMemoryMentored Research Scientist Development AwardMentorsMentorshipMorbidity - disease rateNeurobiologyNeurologistNeuropathogenesisOlder PopulationOperative Surgical ProceduresParticipantPathogenesisPathologicPathologyPersonsPhysician ExecutivesPreventionPreventive InterventionProceduresProspective StudiesQuality of lifeRecordsReportingResearchResearch DesignResearch EthicsResearch InfrastructureResearch PersonnelResearch Project GrantsResearch ProposalsResearch TrainingRiskRisk FactorsSclerosisSepsisServicesSeverity of illnessSocietiesStructureTechnologyTestingTrainingUnited States National Institutes of HealthUniversitiesVascular DiseasesWhite Matter Hyperintensitybasecareercerebral atrophycognitive abilitycognitive changecognitive functioncohortdisabilityexperiencefollow-uphigh riskhippocampal atrophyin vivoinnovationneuroimagingneuropathologyolder patientprofessorprotein TDP-43public health relevancewhite matter
项目摘要
DESCRIPTION (provided by applicant): This is an application for a K01 award by Dr. Bryan D. James, an assistant professor and epidemiologist at the Rush Alzheimer's Disease Center (RADC). The overall goal of this K01 is to build a foundation of knowledge that will enable Dr. James to achieve his long-term goal of establishing himself as an independent investigator in the causes and prevention of cognitive decline in aging. The immediate goal, and the objective of the research application, is to understand how and why hospitalization leads to cognitive decline in some older persons. The award will supplement a strong background in epidemiologic methods and research ethics by providing Dr. James with the training necessary to fill gaps in his knowledge in three critical areas: 1) understanding clinical dementia and assessment of cognitive impairment in older adults, 2) expertise in using medical claims records for research, 3) comprehending the neurobiology and neuropathology of dementia. To achieve competence in these three areas, Dr. James has assembled a mentoring team of experts in complementary fields corresponding to these substantive areas. The primary mentor is Dr. Julie Schneider, the senior neuropathologist of the RADC, who has many years of mentorship experience and has served on and headed the NIA-N K committee. The other three mentors are Dr. David A. Bennett, a neurologist and the Director of the RADC; Dr. Robert S. Wilson, the RADC senior neuropsychologist and respected expert in the study of cognitive aging; and Dr. Raj C. Shah, a geriatrician and the medical director of the Rush Memory Clinic. In addition, Dr. James has assembled an Advisory Committee of experts in: critical care and cognitive impairment (Dr. E. Wesley Ely, Vanderbilt University), neurocritical care (Dr. Thomas Bleck, Rush University Medical Center), use of Medicare records for research (Dr. Jonathan Skinner, Dartmouth University), and neuroimaging (Dr. Konstantinos Arfanakis, RADC and Illinois Institute of Technology). The proposed research project will investigate cognitive decline after hospitalization in older adults; in particular, the prehospital risk factors (Aim 1), responsible hospital characteristics (Aim 2), and pathogenesis (Aim 3) of this phenomenon. The innovative study design will integrate longitudinal cognitive, clinical, neuropathologic, and neuroimaging data from a clinical-pathologic cohort of aging, the Rush Memory and Aging Project, with Medicare claims records providing detailed hospitalization information over more than a decade. Dr. James will leverage the existing data and infrastructure of the Memory and Aging Project and the existing 11 years of Medicare records previously obtained for this project. In addition, Dr. James proposes to obtain 6 more years of Medicare data from the Center for Medicare and Medicare Services (CMS). In Aim 1, Dr. James will examine the prehospital risk factors of accelerated cognitive decline after incident hospitalization and develop a risk profile for such decline. In Aim 2, he will examine the relationship of specific hospital characteristics with accelerated cognitive decline, including ICU stays, surgery, anesthesia, sepsis, and delirium. In Aim 3, he will investigate whether common neuropathologies of dementia, such as Alzheimer's disease and cerebrovascular disease, contribute to cognitive decline after hospitalization. The findings from this research will form the basis of an R01 grant application to the NIH before the end of the funding period.
描述(由申请人提供):这是一个K 01奖的申请博士布赖恩D。他是拉什阿尔茨海默病中心(RADC)的助理教授和流行病学家。该K 01的总体目标是建立知识基础,使James博士能够实现他的长期目标,即成为衰老中认知能力下降的原因和预防的独立研究者。近期目标和研究应用的目的是了解住院治疗如何以及为什么会导致一些老年人的认知能力下降。该奖项将补充流行病学方法和研究伦理的强大背景,为詹姆斯博士提供必要的培训,以填补他在三个关键领域的知识空白:1)了解临床痴呆症和老年人认知障碍的评估,2)使用医疗索赔记录进行研究的专业知识,3)理解痴呆症的神经生物学和神经病理学。为了达到这三个领域的能力,詹姆斯博士组建了一个指导小组,由与这些实质性领域相对应的互补领域的专家组成。主要导师是RADC的高级神经病理学家Julie Schneider博士,他有多年的指导经验,并曾担任NIA-N K委员会主席。其他三位导师是大卫博士。班尼特,神经学家和RADC主任;威尔逊博士是RADC的高级神经心理学家,也是认知老化研究方面受人尊敬的专家。沙阿是老年病学家,也是拉什记忆诊所的医疗主任。此外,詹姆斯博士还组建了一个专家咨询委员会:重症监护和认知障碍(E。韦斯利伊利,范德比尔特大学),神经重症监护(托马斯布莱克博士,拉什大学医学中心),使用医疗保险记录进行研究(乔纳森斯金纳博士,达特茅斯大学),和神经成像(康斯坦丁诺斯Arfanakis博士,RADC和伊利诺伊理工学院)。 拟议的研究项目将调查老年人住院后的认知能力下降;特别是,院前风险因素(目标1),负责任的医院特征(目标2)和发病机制(目标3)。创新的研究设计将整合来自老龄化临床病理队列的纵向认知,临床,神经病理学和神经影像学数据,Rush Memory and Aging Project,以及提供十多年详细住院信息的Medicare索赔记录。詹姆斯博士将利用记忆和衰老项目的现有数据和基础设施,以及先前为该项目获得的现有11年的医疗保险记录。此外,詹姆斯博士建议从医疗保险和医疗保险服务中心(CMS)获得6年以上的医疗保险数据。在目标1中,James博士将检查事件住院后加速认知能力下降的院前风险因素,并制定此类下降的风险特征。在目标2中,他将研究特定医院特征与加速认知功能下降的关系,包括ICU住院、手术、麻醉、败血症和谵妄。在目标3中,他将研究痴呆症的常见神经病理学,如阿尔茨海默病和脑血管疾病,是否会导致住院后的认知能力下降。这项研究的结果将构成在资助期结束前向NIH申请R 01资助的基础。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Bryan David James其他文献
Bryan David James的其他文献
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{{ truncateString('Bryan David James', 18)}}的其他基金
Predictors and consequences of the timing and accuracy of clinical dementia diagnosis
临床痴呆诊断时间和准确性的预测因素和后果
- 批准号:
10559710 - 财政年份:2022
- 资助金额:
$ 11.61万 - 项目类别:
Predictors and consequences of the timing and accuracy of clinical dementia diagnosis
临床痴呆诊断时间和准确性的预测因素和后果
- 批准号:
10370784 - 财政年份:2022
- 资助金额:
$ 11.61万 - 项目类别:
Cognitive decline after hospitalization in older adults: predictors and pathogenesis
老年人住院后认知能力下降:预测因素和发病机制
- 批准号:
9267090 - 财政年份:2015
- 资助金额:
$ 11.61万 - 项目类别:
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