Modeling Auditory Responses and Behavioral Outcomes in Preterm Infants

早产儿的听觉反应和行为结果建模

基本信息

  • 批准号:
    9249151
  • 负责人:
  • 金额:
    $ 22.07万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-08-01 至 2019-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Understanding the causes of variability in auditory neural responses is critical for effective diagnosis of hearing problems and evaluation of neural integrity early in life. Since the Children's Health Act of 2000 (Public Law 106-310) was adopted, most newborns in the US are screened for hearing loss, resulting in more than 65,000 infants being referred every year for further diagnostic auditory testing. Interpretation of these diagnostic tests in infants relies on a thorough understanding of measures from the peripheral and central auditory system. Current norms are based on cross-sectional studies collected from select groups of infants almost 3 decades ago. Because of dramatic changes in health care standards, increased survival rates of infants born prematurely, and new physiological tests that allow evaluation of different anatomical levels of the auditory system, more accurate descriptions of auditory neural responses and relevant normative data are necessary. The proposed research has three specific aims. In the first aim, we will construct models of auditory brainstem responses over time in a diverse and representative infant sample based on objective, physiological measurements reflecting peripheral and central processing. Relevant variables such as high risk factors, prematurity of birth, hearing screening outcome, neurodevelopmental delay and language skills will be used to explain variability in the physiological measures. Infants will be followed on an individual level, with responses recorded longitudinally on experimental measures. The statistical method of hierarchical linear modeling will be used to describe the physiological test data. The second aim is to recast the results in a way that predicts the likelihood of neurodevelopmental and language delay based on auditory and medical variables. In the third aim, we will model language growth and describe its trajectory in relationship to auditory factors. An expected outcome of this study is that modern, sensitive measures will be different for infants with normal hearing and development, infants with different categories of hearing loss, infants with delayed auditory development and infants with more global, neurodevelopmental delays. The results from this study will improve our scientific and clinical knowledge of various auditory measures and couple the auditory measures to language and developmental outcomes, influencing the fields of audiology, neonatology, pediatrics, speech-language pathology and early intervention. The proposed research will improve the public health by accelerating the identification of behavioral delays early in life as well as supplying parents and providers with improved information earlier so that they can make more efficient and timely rehabilitation decisions.
描述(由申请人提供):了解听觉神经反应变异的原因对于有效诊断听力问题和评估生命早期的神经完整性至关重要。自 2000 年《儿童健康法案》(公法 106-310)通过以来,美国大多数新生儿都接受了听力损失筛查,导致每年有超过 65,000 名婴儿被转诊进行进一步的诊断性听力测试。对婴儿这些诊断测试的解释依赖于对周围和中枢听觉系统测量的透彻理解。目前的标准是基于近三十年前从特定婴儿群体中收集的横断面研究。由于医疗保健标准的巨大变化、早产婴儿存活率的提高以及允许评估听觉系统不同解剖水平的新生理测试,因此需要对听觉神经反应和相关规范数据进行更准确的描述。拟议的研究有三个具体目标。第一个目标是,我们将基于反映外周和中枢处理的客观生理测量,在多样化且具有代表性的婴儿样本中构建听觉脑干随时间变化的模型。高风险因素、早产、听力筛查结果、神经发育迟缓和语言技能等相关变量将用于解释生理测量的变异性。将在个体层面上对婴儿进行跟踪,并根据实验测量纵向记录反应。将采用分层线性建模的统计方法来描述生理测试数据。第二个目标是根据听觉和医学变量来预测神经发育和语言延迟的可能性,从而重新调整结果。在第三个目标中,我们将对语言生长进行建模并描述其与听觉因素关系的轨迹。这项研究的预期结果是,对于听力和发育正常的婴儿、不同类别听力损失的婴儿、听觉发育迟缓的婴儿以及整体神经发育迟缓的婴儿,现代、敏感的测量方法将有所不同。这项研究的结果将提高我们对各种听觉测量的科学和临床知识,并将听觉测量与语言和发育结果结合起来,影响听力学、新生儿学、儿科、言语病理学和早期干预领域。拟议的研究将通过加速识别生命早期的行为延迟以及尽早向父母和提供者提供改进的信息来改善公众健康,以便他们能够做出更有效和及时的康复决策。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

LINDA J. HOOD其他文献

LINDA J. HOOD的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('LINDA J. HOOD', 18)}}的其他基金

Annual Meeting of the Population Hearing Health Care (PopHHC) Network
人口听力保健 (PopHHC) 网络年会
  • 批准号:
    10520060
  • 财政年份:
    2021
  • 资助金额:
    $ 22.07万
  • 项目类别:
Annual Meeting of the Population Hearing Health Care (PopHHC) Network
人口听力保健 (PopHHC) 网络年会
  • 批准号:
    10391831
  • 财政年份:
    2021
  • 资助金额:
    $ 22.07万
  • 项目类别:
Middle-ear reflex testing using wideband acoustic immittance
使用宽带声导抗进行中耳反射测试
  • 批准号:
    10260596
  • 财政年份:
    2018
  • 资助金额:
    $ 22.07万
  • 项目类别:
Modeling Auditory Responses and Behavioral Outcomes in Preterm Infants
早产儿的听觉反应和行为结果建模
  • 批准号:
    8758060
  • 财政年份:
    2014
  • 资助金额:
    $ 22.07万
  • 项目类别:
Modeling Auditory Responses and Behavioral Outcomes in Preterm Infants
早产儿的听觉反应和行为结果建模
  • 批准号:
    9318492
  • 财政年份:
    2014
  • 资助金额:
    $ 22.07万
  • 项目类别:
Modeling Auditory Responses and Behavioral Outcomes in Preterm Infants
早产儿的听觉反应和行为结果建模
  • 批准号:
    9524980
  • 财政年份:
    2014
  • 资助金额:
    $ 22.07万
  • 项目类别:
Developing Research Careers in the Hearing Sciences
发展听力科学研究事业
  • 批准号:
    8433305
  • 财政年份:
    2007
  • 资助金额:
    $ 22.07万
  • 项目类别:
Developing Research Careers in the Hearing Sciences
发展听力科学研究事业
  • 批准号:
    7233450
  • 财政年份:
    2007
  • 资助金额:
    $ 22.07万
  • 项目类别:
Developing Research Careers in the Hearing Sciences
发展听力科学研究事业
  • 批准号:
    9894779
  • 财政年份:
    2007
  • 资助金额:
    $ 22.07万
  • 项目类别:
Developing Research Careers in the Hearing Sciences
发展听力科学研究事业
  • 批准号:
    8266589
  • 财政年份:
    2007
  • 资助金额:
    $ 22.07万
  • 项目类别:

相似海外基金

Auditory Neuroscience - The architecture and principles governing neural responses to natural sounds
听觉神经科学 - 控制神经对自然声音反应的架构和原理
  • 批准号:
    2748747
  • 财政年份:
    2022
  • 资助金额:
    $ 22.07万
  • 项目类别:
    Studentship
Responses to F1 altered auditory feedback in typically developing children
正常发育儿童对 F1 的反应改变了听觉反馈
  • 批准号:
    576031-2022
  • 财政年份:
    2022
  • 资助金额:
    $ 22.07万
  • 项目类别:
    Alexander Graham Bell Canada Graduate Scholarships - Master's
Responses of the rat's midbrain auditory neutrons to a pair of leading-trailing sounds
大鼠中脑听觉中子对一对前导声音的反应
  • 批准号:
    539610-2019
  • 财政年份:
    2019
  • 资助金额:
    $ 22.07万
  • 项目类别:
    University Undergraduate Student Research Awards
Contextual modulation of neural responses in the bat auditory cortex
蝙蝠听觉皮层神经反应的情境调节
  • 批准号:
    428645493
  • 财政年份:
    2019
  • 资助金额:
    $ 22.07万
  • 项目类别:
    Research Grants
Measurement and Applications of Speech-evoked Auditory Brainstem Responses (sABRs)
言语诱发听觉脑干反应(sABR)的测量和应用
  • 批准号:
    RGPIN-2014-05118
  • 财政年份:
    2018
  • 资助金额:
    $ 22.07万
  • 项目类别:
    Discovery Grants Program - Individual
A comparison of bottom-up and top-down training approaches: Brain responses as objective outcome measures of auditory training for improving speech perception in noise.
自下而上和自上而下训练方法的比较:大脑反应作为听觉训练的客观结果测量,以改善噪声中的言语感知。
  • 批准号:
    397807552
  • 财政年份:
    2017
  • 资助金额:
    $ 22.07万
  • 项目类别:
    Research Fellowships
Measurement and Applications of Speech-evoked Auditory Brainstem Responses (sABRs)
言语诱发听觉脑干反应(sABR)的测量和应用
  • 批准号:
    RGPIN-2014-05118
  • 财政年份:
    2017
  • 资助金额:
    $ 22.07万
  • 项目类别:
    Discovery Grants Program - Individual
Influence of short-term vocal training on auditory brainstem responses
短期发声训练对听觉脑干反应的影响
  • 批准号:
    511700-2017
  • 财政年份:
    2017
  • 资助金额:
    $ 22.07万
  • 项目类别:
    University Undergraduate Student Research Awards
Maturational changes in auditory cortical responses in 4-6 year olds
4-6岁儿童听觉皮层反应的成熟变化
  • 批准号:
    498067-2016
  • 财政年份:
    2016
  • 资助金额:
    $ 22.07万
  • 项目类别:
    University Undergraduate Student Research Awards
Chirp-evoked auditory steady-state responses: Optimal parameters for rapid and objective tests of hearing
鸣叫诱发的听觉稳态响应:快速客观听力测试的最佳参数
  • 批准号:
    326379052
  • 财政年份:
    2016
  • 资助金额:
    $ 22.07万
  • 项目类别:
    Research Grants
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了