L-amino acid sensing by the extracellular calcium-sensing receptor: molecular, cellular and in vivo studies

细胞外钙感应受体对 L-氨基酸的感应：分子、细胞和体内研究

• 批准号: nhmrc : 153966
• 负责人: Prof Arthur Conigrave
• 金额: $ 24.17万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/l-amino-acid-vivo-studies/100509
• 关键词: amino; acid; sensing; extracellular; calcium

Recent work by Dr Conigrave and colleagues demonstrates for the first time that protein and calcium metabolism are linked at the molecular level by the widely distributed calcium-sensing receptor. The project will aim to demonstrate the physiological significance of this finding by testing whether L-amino acids, the building blocks of body protein, exert receptor-dependent control over the secretion and blood levels of hormones that regulate body calcium levels. It will further test the hypothesis by determining whether amino acids exert receptor-dependent control over the proliferation of bone forming cells and urinary excretion of calcium.

coniggrave博士和他的同事们最近的工作首次证明了蛋白质和钙的代谢是通过广泛分布的钙感应受体在分子水平上联系在一起的。该项目旨在通过测试人体蛋白质的组成部分l -氨基酸是否对调节体内钙水平的激素的分泌和血液水平施加受体依赖的控制，来证明这一发现的生理学意义。它将通过确定氨基酸是否对骨形成细胞的增殖和尿液中钙的排泄施加受体依赖的控制来进一步验证这一假设。