Molecular mechanism and novel activators of amino acid and calcium-sensing class 3 G-protein coupled receptors

氨基酸和钙敏感3类G蛋白偶联受体的分子机制和新型激活剂

• 批准号: nhmrc : 512546
• 负责人: Prof Arthur Conigrave
• 金额: $ 34.65万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-mechanism-novel-coupled-receptors/82131
• 关键词: Molecular; mechanism; novel; activators; amino

When we eat protein-containing foods, our bodies extract twenty different amino acids for growth and tissue regeneration. Broad-spectrum amino acid sensing receptors detect the increases in blood amino acid levels and respond by triggering the release of biochemical signals. This project will establish the molecular rules by which these receptors work and identify novel activators with potential therapeutic application for the control of growth, tissue regeneration and calcium metabolism.

当我们吃含蛋白质的食物时，我们的身体会提取20种不同的氨基酸用于生长和组织再生。广谱氨基酸传感受体检测血液氨基酸水平的增加，并通过触发生化信号的释放作出反应。该项目将建立这些受体工作的分子规则，并确定具有控制生长，组织再生和钙代谢的潜在治疗应用的新型激活剂。