COBRE for Perinatal Biology

 描述(申请人提供)：我们Cobre的科学目标是增加我们对生殖生物学和心肺发育的了解，加强我们对围产期疾病(如先兆子痫和早产)的了解，并为新的治疗策略开发新的机会。我们在第一阶段和第二阶段的研究重点是认识到调节胚胎发育、癌症和衰老的基本机制是重叠的。我们项目的成功得到了增强，因为人们普遍认为，透过这个“发展的棱镜”，可以为日后如何治理监管路径提供独特的实验杠杆和可测试的假说。科布雷的计划目标一直是创建一个围产期生物学中心，在一个促进创造力和跨学科合作的环境中为初级教师提供科学和职业指导。在Cobre围产期生物学第三阶段，我们的目标将是：1)继续支持与Cobre相关的活动；2)将该中心过渡到可持续性；以及3)加强妇女和婴儿医院的围产期和发育研究。研究核心计划的资源将用于升级现有仪器，以增强我们的研究复杂性。与第三阶段Cobre相关的试点赠款计划将用于刺激合作研究努力，这将有助于研究人员之间的联合申请和持续资源 对于核心设施。我们已经确定的实现这些目标的具体目标是：具体目标1：提供全面领导，支持行政核心管理操作的能力，并将围产期生物学科布雷转变为可持续发展的围产期生物学中心，实现长期可持续发展。具体目标2：开发一个可持续的、最先进的研究核心，最大限度地利用和影响围产期研究的当代方法、设备和技术。具体目标3：利用试点助学金计划资源催化多学科研究，从而在围产期研究中获得额外的校外奖项。

 DESCRIPTION (provided by applicant): The scientific aims of our COBRE have been to increase our understanding of reproductive biology and cardiopulmonary development, to enhance our understanding of perinatal diseases, like preeclampsia and preterm birth, and to develop new opportunities for novel therapeutic strategies. Our research focus during Phase I and Phase II has been driven by recognition that the fundamental mechanisms that regulate embryonic development, cancer, and aging are overlapping. The success of our projects has been enhanced by the common view that looking through this "prism of development" provides unique experimental leverage and testable hypotheses for how regulatory pathways are governed later in life. The programmatic aims of the COBRE have been to create a Center for Perinatal Biology providing scientific and career mentoring to junior faculty within an environment fostering creativity and transdisciplinary collaboration. During Phase III of the COBRE for Perinatal Biology, our objectives will be: 1) continued support of COBRE-related activities; 2) transition the Center to sustainability; and 3) enhance perinatal and developmental research at Women & Infants Hospital. Resources for the Research Core programs will be used to upgrade existing instrumentation to enhance our research sophistication. The Pilot Grants Program associated with the Phase-III COBRE will be used to stimulate collaborative research efforts that will contribute to joint applications among the investigators and sustaining resources for the Core Facilities. The Specific Aims we have identified to accomplish these goals are: Specific Aim 1: Provide Overall Leadership supporting the Administrative Core's ability to manage the operations and to transition the COBRE for Perinatal Biology into a sustainable Center for Perinatal Biology toward long-term sustainability. Specific Aim 2: Develop a sustainable, state-of-the-art Research Core that maximizes the use and impact of contemporary approaches, equipment, and technology for Perinatal Research. Specific Aim 3: Utilize Pilot Grants Program resources to catalyze multi-disciplinary research leading to additional extramural awards in Perinatal Research.