Gene Wiki: expanding the ecosystem of community-intelligence resources

Gene Wiki：扩大社区情报资源的生态系统

• 批准号: 8891444
• 负责人: ANDREW I SU
• 金额: $ 48.53万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8891444
• 关键词: Address; Biological; Biomedical Research; Collection; Communities; Crowding; Data; Data Display; Databases; Development; Disease; Ecosystem; Educational Curriculum; Ensure; Environment; Faculty; Feedback; Foundations; Funding; Genes; Genome; Genomics; Goals; Growth; Harvest; Health; Housing; Human; Incentives; Individual; Information Resources Management; Intelligence; Internet; Journals; Knowledge; Learning; Life; Link; Literature; Maintenance; Methods; Microbiology; Mining; Modeling; Patients; Peer Review; Pharmaceutical Preparations; Population; Progress Reports; Property; Publications; Rare Diseases; Reader; Research; Research Infrastructure; Resources; Solid; Source; Students; System; Text; Time; Trees; Update; Wit; Work; Writing; base; database structure; design; file format; gene function; genetic resource; genome annotation; genome sequencing; improved; instructor; interest; member; microbial; model organisms databases; novel; outreach; text searching; tool; web interface; wiki

DESCRIPTION (provided by applicant): This proposal describes the continued maintenance and development of the Gene Wiki, the goal of which is to create a continuously-updated, community-reviewed, and collaboratively-written review article for every human gene. The Gene Wiki was created directly within Wikipedia as an informal collection of 10,646 gene-specific articles. In the first funding period, the infrastructure to keep Gene Wiki "infoboxes" in sync wit the source databases in the genomics community was developed. Next, methods to assess and quantify the trustworthiness of each word of a Gene Wiki article were developed and implemented in a system called WikiTrust. And finally, simple text-mining applied to Gene Wiki was able to identify thousands of novel gene annotations. During the next project period, the Gene Wiki is poised to make further strides. First, the scope of the Gene Wiki will be expanded to also include review articles on diseases and drugs. Thousands of articles will either be created or maintained through this initiative with a particular emphasis on rare diseases. Second, a dedicated outreach component will ensure that the community of editors is poised to grow. This outreach effort will engage both faculty members who are experts on specific genes of interest, as well as classroom instructors at all levels who want to design curriculum based on the Gene Wiki for a class project. Third, a "Centralized Model Organism Database" will be constructed in the Wikidata environment, which will serve as a clearing house of microbial gene and genome annotation data. And fourth an entirely new crowdsourcing application will be created that taps into crowds of patient-aligned individuals and their desire to advance research. These individuals will be a novel crowd that will be applied to the challenge of systematically annotating the biomedical literature. In summary, the Gene Wiki is a useful tool for biomedical research. Successful completion of this proposal will result in more efficient knowledge management and dissemination through crowdsourcing.

描述（由申请人提供）：本提案描述了基因维基的持续维护和开发，其目标是为每个人类基因创建持续更新，社区评审和协作撰写的评论文章。基因维基是直接在维基百科中创建的，作为10，646篇基因特定文章的非正式集合。在第一个资助期内，开发了使基因维基“信息框”与基因组学社区的源数据库保持同步的基础设施。接下来，评估和量化基因维基文章中每个单词的可信度的方法被开发并在一个名为WikiTrust的系统中实现。最后，应用于Gene Wiki的简单文本挖掘能够识别数千个新的基因注释。在下一个项目期间，基因维基准备取得进一步的进展。首先，基因维基的范围将扩大到也包括关于疾病和药物的评论文章。通过这一举措，将创建或维护数千篇文章，特别强调罕见疾病。第二，一个专门的外联部门将确保编辑群体随时准备壮大。这项推广工作将涉及教师谁是感兴趣的特定基因的专家，以及课堂教师在各级谁想要设计课程的基础上基因维基类项目。第三，将在维基数据环境中建立一个“集中模式生物数据库”，作为微生物基因和基因组注释数据的交换所。第四，将创建一个全新的众包应用程序，利用与患者相关的人群及其对推进研究的愿望。这些人将是一个新的人群，将适用于系统地注释生物医学文献的挑战。总之，基因维基是生物医学研究的有用工具。成功完成该提案将通过众包实现更有效的知识管理和传播。