Diverse Drug Lead Compounds from Bacterial Symbionts in Philippine Mollusks

菲律宾软体动物细菌共生体中的多种药物先导化合物

• 批准号: 9127839
• 负责人: Margo Genevieve Haygood
• 金额: $ 98.06万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9127839
• 关键词: Academy; Animals; Bacteria; Bacterial Infections; Biodiversity; Chemicals; Communicable Diseases; Cryptosporidium; Distel; Education; Foundations; Future; Gap Junctions; Government; Health; Health Sciences; Human; Human Resources; Lead; Malignant Neoplasms; Marines; Medical center; Natural Products; Natural Resources; Natural Sciences; Neurologic; Oregon; Pain; Parasites; Parasitic infection; Pharmaceutical Preparations; Philippines; Population; Research; Technology; Therapeutic; Training and Infrastructure; United States; Universities; Utah; marine natural product; microbial; nervous system disorder; novel; novel therapeutics; parasitism; pathogen; tool

DESCRIPTION (provided by applicant): Group Plan Summary: The Philippine Mollusk Symbiont ICBG (PMS-ICBG) harnesses the vast biodiversity of the Philippines to discover new drugs to treat bacterial infections, parasitic infections, pain and other neurological conditions and cancer, all of which are serious health problems in both the Philippines and the United States. The Republic of the Philippines represents a unique nexus of exceptional biodiversity, dense human population with pressing societal needs, consequent urgent need for conservation, and government commitment to education and technology to harness national human and natural resources for a sustainable future. Our focus is mollusks and their microbial symbionts; mollusks are one of the most diverse groups of marine animals, and their associated bacteria represent an unexplored trove of chemical diversity. The PMS- ICBG will use our increasing understanding of the interactions between mollusk symbionts and their hosts to discover the most novel and useful molecules. The project will document and describe Philippine mollusk biodiversity and support training and infrastructure that provide the foundation for conservation of Philippine biodiversity. The project is led by Margo Haygood, marine microbiologist, Oregon Health & Science University in association with Gisela Concepcion, marine natural products chemist, University of the Philippines, Diliman; Baldomero Olivera, biochemist and Eric Schmidt, natural products chemist and biochemist, both of University of Utah, Gary Rosenberg, malacologist, of the Academy of Natural Sciences, Drexel University, Daniel Distel, marine microbiologist, Northeastern University, and Roberta O'Connor, parasitologist, Tufts Medical Center.

菲律宾软体动物共生体ICBG（PMS-ICBG）利用菲律宾广阔的生物多样性来发现治疗细菌感染，寄生虫感染，疼痛和其他神经系统疾病和癌症的新药，所有这些都是菲律宾和美国的严重健康问题。菲律宾共和国是一个独特的联系，其独特的生物多样性、人口稠密、社会需求迫切、因此迫切需要保护，以及政府致力于教育和技术，以利用国家人力和自然资源实现可持续的未来。我们的重点是软体动物和它们的微生物共生体;软体动物是海洋动物中最多样化的群体之一，它们的相关细菌代表了化学多样性的未开发宝藏。PMS-ICBG将利用我们对软体动物共生体及其宿主之间相互作用的日益了解来发现最新颖和有用的分子。该项目将记录和描述菲律宾软体动物的生物多样性，并支持为保护菲律宾生物多样性奠定基础的培训和基础设施。该项目由俄勒冈州健康与科学大学海洋微生物学家Margo Haygood与菲律宾大学Diliman海洋天然产品化学家Gisela孔塞普西翁共同领导; Baldomero Olivera，生物化学家和Eric施密特，天然产物化学家和生物化学家，都来自犹他州大学，加里罗森伯格，自然科学院，德雷克塞尔大学，丹尼尔Distel，海洋微生物学家，东北大学和罗伯塔奥康纳，寄生虫学家，塔夫茨医疗中心。