Diverse Drug Lead Compounds from Bacterial Symbionts in Philippine Mollusks

菲律宾软体动物细菌共生体中的多种药物先导化合物

• 批准号: 9127839
• 负责人: Margo Genevieve Haygood
• 金额: $ 98.06万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9127839
• 关键词: Academy; Animals; Bacteria; Bacterial Infections; Biodiversity; Chemicals; Communicable Diseases; Cryptosporidium; Distel; Education; Foundations; Future; Gap Junctions; Government; Health; Health Sciences; Human; Human Resources; Lead; Malignant Neoplasms; Marines; Medical center; Natural Products; Natural Resources; Natural Sciences; Neurologic; Oregon; Pain; Parasites; Parasitic infection; Pharmaceutical Preparations; Philippines; Population; Research; Technology; Therapeutic; Training and Infrastructure; United States; Universities; Utah; marine natural product; microbial; nervous system disorder; novel; novel therapeutics; parasitism; pathogen; tool

DESCRIPTION (provided by applicant): Group Plan Summary: The Philippine Mollusk Symbiont ICBG (PMS-ICBG) harnesses the vast biodiversity of the Philippines to discover new drugs to treat bacterial infections, parasitic infections, pain and other neurological conditions and cancer, all of which are serious health problems in both the Philippines and the United States. The Republic of the Philippines represents a unique nexus of exceptional biodiversity, dense human population with pressing societal needs, consequent urgent need for conservation, and government commitment to education and technology to harness national human and natural resources for a sustainable future. Our focus is mollusks and their microbial symbionts; mollusks are one of the most diverse groups of marine animals, and their associated bacteria represent an unexplored trove of chemical diversity. The PMS- ICBG will use our increasing understanding of the interactions between mollusk symbionts and their hosts to discover the most novel and useful molecules. The project will document and describe Philippine mollusk biodiversity and support training and infrastructure that provide the foundation for conservation of Philippine biodiversity. The project is led by Margo Haygood, marine microbiologist, Oregon Health & Science University in association with Gisela Concepcion, marine natural products chemist, University of the Philippines, Diliman; Baldomero Olivera, biochemist and Eric Schmidt, natural products chemist and biochemist, both of University of Utah, Gary Rosenberg, malacologist, of the Academy of Natural Sciences, Drexel University, Daniel Distel, marine microbiologist, Northeastern University, and Roberta O'Connor, parasitologist, Tufts Medical Center.

描述（由申请人提供）：小组计划摘要：菲律宾Mollusk Symbiont ICBG（PMS-ICBG）都在菲律宾的巨大生物多样性中发现新药，以治疗细菌感染，寄生虫感染，疼痛和其他神经系统状况和其他癌症，所有这些都在菲律宾和菲律宾国家都严重健康问题。菲律宾共和国代表了特殊的生物多样性，人口密集的人口的独特联系，紧迫的社会需求，因此迫切需要保护以及政府对教育和技术的承诺，以利用民族人力和自然资源来实现可持续的未来。我们的重点是软体动物及其微生物共生体。软体动物是最多样化的海洋动物群体之一，它们的相关细菌代表了尚未探索的化学多样性。 PMS-ICBG将利用我们对软体动物共生体及其宿主之间相互作用的不断理解，以发现最新颖和最有用的分子。该项目将记录并描述菲律宾软体动物的生物多样性和支持培训和基础设施，为菲律宾生物多样性提供基础。该项目由俄勒冈州健康与科学大学海洋微生物学家Margo Haygood与Gisela Concepcion，Marine Natural Products化学家，菲律宾大学，迪利曼大学的海洋天然产品化学家联合领导；犹他大学的天然产品化学家和生物化学家埃里克·施密特（Eric Sc​​hmidt），鲍尔多梅罗·奥利弗拉（Baldomero Olivera），犹他大学，加里·罗森伯格（Gary Rosenberg），自然科学院，丹尼尔·斯特雷尔（Drexel University），丹尼尔·德赛尔（Drexel），海洋微生物学家，北部北欧大学海洋微生物学家，北欧大学和罗伯塔·奥康纳尔（Roberta O'Connor，Parasitosic），Tufts Medical Center。