Diverse Drug Lead Compounds from Bacterial Symbionts in Philippine Mollusks

菲律宾软体动物细菌共生体中的多种药物先导化合物

• 批准号: 9132381
• 负责人: Margo Genevieve Haygood
• 金额: $ 6.89万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9132381
• 关键词: Academy; Animals; Bacteria; Bacterial Infections; Biodiversity; Bioinformatics; Biological Assay; Biological Factors; Chemicals; Chemistry; Communicable Diseases; Communication; Cryptosporidium; Distel; Documentation; Economic Development; Education; Fostering; Foundations; Future; Gap Junctions; Genomics; Government; Health; Health Sciences; Human; Human Resources; Industry; Lead; Malignant Neoplasms; Marines; Medical center; Microbiology; Natural Resources; Natural Sciences; Nature; Neurologic; Oregon; Pain; Parasites; Parasitic infection; Pharmaceutical Preparations; Philippines; Population; Research; Science; Scientist; Technology; Therapeutic; Toxoplasma; Training; Training and Infrastructure; United States; Universities; Utah; base; benefit sharing; drug discovery; marine natural product; microbial; nervous system disorder; novel; parasitism; pathogen; tool

DESCRIPTION (provided by applicant): Group Plan Summary: The Philippine Mollusk Symbiont ICBG (PMS-ICBG) harnesses the vast biodiversity of the Philippines to discover new drugs to treat bacterial infections, parasitic infections, pain and other neurological conditions and cancer, all of which are serious health problems in both the Philippines and the United States. The Republic of the Philippines represents a unique nexus of exceptional biodiversity, dense human population with pressing societal needs, consequent urgent need for conservation, and government commitment to education and technology to harness national human and natural resources for a sustainable future. Our focus is mollusks and their microbial symbionts; mollusks are one of the most diverse groups of marine animals, and their associated bacteria represent an unexplored trove of chemical diversity. The PMS- ICBG will use our increasing understanding of the interactions between mollusk symbionts and their hosts to discover the most novel and useful molecules. The project will document and describe Philippine mollusk biodiversity and support training and infrastructure that provide the foundation for conservation of Philippine biodiversity. The project is led by Margo Haygood, marine microbiologist, Oregon Health & Science University in association with Gisela Concepcion, marine natural products chemist, University of the Philippines, Diliman; Baldomero Olivera, biochemist and Eric Schmidt, natural products chemist and biochemist, both of University of Utah, Gary Rosenberg, malacologist, of the Academy of Natural Sciences, Drexel University, Daniel Distel, marine microbiologist, Northeastern University, and Roberta O'Connor, parasitologist, Tufts Medical Center.

描述（由申请人提供）： 团体计划摘要：菲律宾软体动物共生体 ICBG (PMS-ICBG) 利用菲律宾丰富的生物多样性来发现治疗细菌感染、寄生虫感染、疼痛和其他神经系统疾病和癌症的新药，所有这些都是菲律宾和美国严重的健康问题。菲律宾共和国代表了独特的联系：卓越的生物多样性、人口稠密、社会需求迫切、因此迫切需要保护，以及政府致力于教育和技术以利用国家人力和自然资源实现可持续的未来。我们的重点是软体动物及其微生物共生体；软体动物是海洋动物中最多样化的群体之一，它们的相关细菌代表着未经开发的化学多样性宝库。 PMS-ICBG 将利用我们对软体动物共生体与其宿主之间相互作用的日益了解来发现最新颖、最有用的分子。该项目将记录和描述菲律宾软体动物生物多样性，并支持为保护菲律宾生物多样性奠定基础的培训和基础设施。该项目由俄勒冈健康与科学大学海洋微生物学家 Margo Haygood 与菲律宾迪利曼大学海洋天然产物化学家 Gisela Concepcion 联合领导；犹他大学的生物化学家 Baldomero Olivera 和天然产物化学家和生物化学家 Eric Sc​​hmidt、德雷塞尔大学自然科学院的软体学家 Gary Rosenberg、东北大学的海洋微生物学家 Daniel Distel 和塔夫茨医学中心的寄生虫学家 Roberta O'Connor。