Web Application and Services for Methodologically Rigorous Animal Study Design

 产品说明：我们在这个项目中的目标是开发一个网络应用程序，以指导研究人员在动物研究的高效和有效的设计，平衡最大限度地减少动物使用和提供严格的，可重复的结果的竞争需求。三个基本思想，直接转化为我们的三个具体目标，构成了我们提出的工具的基础。首先，将科学置于统计学之前：为试点、探索性或假设驱动的研究制定科学计划，明确动物选择、圈养和治疗计划的利益和结构的影响。其次是通过功效计算对样本量和效应量进行前瞻性检查。第三是随时可以获得设计和统计专业人员的专家支持。 拟议的研究是在实验设计和分析的网络应用程序的开发的第一阶段。我们的第一阶段工作将展示一个原型的动态网络应用程序，提供定性和定量的决策支持，以及人对人的在线聊天能力，快速技术援助与研究设计的概念。与我们在加州大学圣地亚哥分校和加州大学戴维斯分校的队友合作，我们将从他们丰富的动物研究经验中开发一系列案例研究，包括研究目标和问题复杂性。从这些例子中，我们将开发用例来设计用户-系统交互，这将构成软件开发的基础。

 DESCRIPTION: Our goal in this project is to develop a web-application to guide researchers in the efficient and effective design of animal studies that balance the competing needs of minimizing animal use and providing rigorous, repeatable results. Three basic ideas, which translate directly into our three specific aims, form the foundation of our proposed tool. First an foremost is to place science before statistics: develop the science plan for a pilot, exploratory o hypothesis-driven study with a clear idea of the effects of interest and structure of the animal selection, housing, and treatment plan. Second is a prospective examination of sample size and effect size through power computations. Third is ready access to expert support with design and statistics professionals. The proposed study is the first phase in the development of a web-application for experimental design and analysis. Our Phase I effort will demonstrate the concept with a prototype dynamic web application that provides qualitative and quantitative decision support together with person-to-person on-line chat capability for rapid technical assistance with study design. In collaboration with our teammates at UC San Diego and UC Davis, we will develop a set of example case studies from their extensive animal research experience, ranging both in study goals and problem complexity. From these examples, we will develop use cases to design the user-system interactions that will form the software development foundation.