Comprehensive Training Program in Musculoskeletal Research

 描述（由申请人提供）：项目摘要本提案的目的是在印第安纳州大学医学院重新建立T32肌肉骨骼生物学培训计划。培训计划的目标是利用IU Bone Group的科学深度，指导技能和经验，为博士生和博士后研究员提供骨骼生物学方面丰富，多样化，多学科的培训环境。该计划将为他们提供所需的工具和培训，以便他们成为成功的医生，科学家和工程师，他们将找到新的治疗方法，开发新的治疗方法，并产生新的设备来减少和/或消除肌肉骨骼疾病。我们已经招募了23名参与IU培训的教师担任该计划的导师。我们的培训教师集体跨越 在骨骼科学的一系列重点领域，包括骨癌和转移、性激素信号、磷酸盐代谢、生物力学、骨细胞的分子和细胞生物学、骨折愈合、药物作用机制、促钙激素、机械转导、骨骼遗传学、人类骨骼疾病、基质特性、软骨生物学、肌肉生物学和发育生物学等。这组教员有着良好的培训记录，今年从联邦机构（如NIH、DOD、VA）获得了超过1000万美元的外部资金作为PI。对于该计划的拟议5年期，要求支持3名博士前和3名博士后学员。我们为博士前学生和博士后研究员精心设计了个人培训计划，旨在让学员接触骨骼研究的跨学科方法，同时让他们专注于一组特定的研究问题。博士预科学生将参加我们的内部基本骨生物学课程和研究课程的负责任行为作为学位要求的一部分;参加每周骨杂志俱乐部和每月骨和矿物质俱乐部系列讲座，在副导师的实验室进行博士研究的一部分;每年参加一次专业会议;并参加每年在校园举行的至少一次资助写作研讨会。博士后研究员将从事类似的项目，但许多（但不是全部）列出的活动将被推荐而不是要求，因为博士后研究员没有学位要求。培训方案对多样性问题很敏感，并将尽一切努力招募代表性不足的少数民族参加该方案。通过在为肌肉骨骼研究提供强有力的多学科支持的环境和文化中进行培训，学员很可能会对骨骼生物学保持浓厚的兴趣，即使他们的具体研究兴趣在他们的职业生涯中不断发展。

 DESCRIPTION (provided by applicant): Project Summary The purpose of this proposal is to re-establish a T32 training program in musculoskeletal biology at Indiana University School of Medicine. The objective of the training program is to capitalize on the IU Bone Group's scientific depth, mentoring skills, and experience to provide PhD students and postdoctoral fellows with a rich, diverse, multidisciplinary training environment in skeletal biology. The program will equip them with tools and training needed to move into successful careers as physicians, scientists, and engineers who will find new cures, develop new therapeutic treatments, and generate new devices to reduce and/or eliminate musculoskeletal disease. We have enlisted 23 participating IU training faculty to serve as mentors in this program. Our training faculty collectively span the spectrum of focus areas in skeletal science, including bone cancer and metastasis, sex hormone signaling, phosphate metabolism, biomechanics, molecular and cellular biology of bone cells, fracture healing, mechanisms of drug action, calcitropic hormones, mechanotransduction, skeletal genetics, human skeletal disease, matrix properties, cartilage biology, muscle biology, and developmental biology, among others. This group of faculty has a strong training record and has over $10M of external funding this year from the federal agencies (e.g. NIH, DOD, VA) as PIs. For the proposed 5-year duration of this program, support for 3 pre- and 3 post-doctoral trainees is requested. We have carefully crafted individual training programs for predoctoral students and postdoctoral fellows that are designed to expose trainees to a cross-disciplinary approach to skeletal research, while allowing them to focus on a particular set of research questions. Pre-doctoral students will take our in-house Basic Bone Biology course and the Responsible Conduct of Research course as part of the degree requirements; attend weekly Bone Journal Club and the monthly Bone and Mineral Club lecture series, conduct a portion of their doctoral research in an associate mentor's laboratory; attend one professional meeting per year; and attend at least one grant writing workshop that is held annually on campus. Postdoctoral fellows will engage in a similar program, but many (but not all) of the listed activities will be recommended rather than required, since postdoctoral fellows lack degree requirements. The training program is sensitive to the issue of diversity and will make every effort to recruit underrepresented minorities into the program. By training in an environment and culture that gives strong multi-disciplinary support for musculoskeletal research, there is a significant probability that the trainees will sustain a keen interest in skeltal biology, even as their specific research interests evolve over their careers.