Comprehensive Training Program in Musculoskeletal Research

 描述(由申请者提供)：项目摘要这项建议的目的是在印第安纳大学医学院重建肌肉骨骼生物学的T32培训计划。该培训计划的目标是利用IU bone Group的科学深度、指导技能和经验，为博士生和博士后研究员提供丰富、多样化、多学科的骨骼生物学培训环境。该计划将为他们提供必要的工具和培训，使他们能够进入成功的医生、科学家和工程师的职业生涯，他们将找到新的治疗方法，开发新的治疗方法，并产生新的设备来减少和/或消除肌肉骨骼疾病。我们招募了23名参与该项目的英语系培训教师作为导师。我们的培训人员集体跨越了 骨骼科学的焦点领域包括骨癌和转移、性激素信号转导、磷酸盐代谢、生物力学、骨细胞的分子和细胞生物学、骨折愈合、药物作用机制、促钙激素、机械转导、骨骼遗传学、人类骨骼疾病、基质特性、软骨生物学、肌肉生物学和发育生物学等。这群教师有着良好的培训记录，今年从联邦机构(如NIH、国防部、弗吉尼亚州)获得了超过1000万美元的外部资金作为绩效指标。对于该计划拟议的5年期，需要为3名博士后和3名博士后实习生提供支持。我们为博士后学生和博士后研究员精心设计了个人培训计划，旨在让受训人员接触跨学科的骨骼研究方法，同时允许他们专注于一组特定的研究问题。作为学位要求的一部分，博士生将学习我们内部的基础骨生物学课程和负责任的研究行为课程；参加每周一次的骨杂志俱乐部和每月一次的骨与矿物俱乐部系列讲座；在副导师的实验室进行部分博士研究；每年参加一次专业会议；以及参加至少一次在校园内每年举行的拨款撰写研讨会。博士后研究员将参与类似的项目，但许多(但不是所有)列出的活动将被推荐，而不是必需的，因为博士后研究员没有学位要求。该培训计划对多样性问题非常敏感，并将尽一切努力招募代表性不足的少数族裔加入该计划。通过在为肌肉骨骼研究提供强有力的多学科支持的环境和文化中进行培训，受训者很有可能保持对骨骼生物学的浓厚兴趣，即使他们的特定研究兴趣在他们的职业生涯中不断发展。

 DESCRIPTION (provided by applicant): Project Summary The purpose of this proposal is to re-establish a T32 training program in musculoskeletal biology at Indiana University School of Medicine. The objective of the training program is to capitalize on the IU Bone Group's scientific depth, mentoring skills, and experience to provide PhD students and postdoctoral fellows with a rich, diverse, multidisciplinary training environment in skeletal biology. The program will equip them with tools and training needed to move into successful careers as physicians, scientists, and engineers who will find new cures, develop new therapeutic treatments, and generate new devices to reduce and/or eliminate musculoskeletal disease. We have enlisted 23 participating IU training faculty to serve as mentors in this program. Our training faculty collectively span the spectrum of focus areas in skeletal science, including bone cancer and metastasis, sex hormone signaling, phosphate metabolism, biomechanics, molecular and cellular biology of bone cells, fracture healing, mechanisms of drug action, calcitropic hormones, mechanotransduction, skeletal genetics, human skeletal disease, matrix properties, cartilage biology, muscle biology, and developmental biology, among others. This group of faculty has a strong training record and has over $10M of external funding this year from the federal agencies (e.g. NIH, DOD, VA) as PIs. For the proposed 5-year duration of this program, support for 3 pre- and 3 post-doctoral trainees is requested. We have carefully crafted individual training programs for predoctoral students and postdoctoral fellows that are designed to expose trainees to a cross-disciplinary approach to skeletal research, while allowing them to focus on a particular set of research questions. Pre-doctoral students will take our in-house Basic Bone Biology course and the Responsible Conduct of Research course as part of the degree requirements; attend weekly Bone Journal Club and the monthly Bone and Mineral Club lecture series, conduct a portion of their doctoral research in an associate mentor's laboratory; attend one professional meeting per year; and attend at least one grant writing workshop that is held annually on campus. Postdoctoral fellows will engage in a similar program, but many (but not all) of the listed activities will be recommended rather than required, since postdoctoral fellows lack degree requirements. The training program is sensitive to the issue of diversity and will make every effort to recruit underrepresented minorities into the program. By training in an environment and culture that gives strong multi-disciplinary support for musculoskeletal research, there is a significant probability that the trainees will sustain a keen interest in skeltal biology, even as their specific research interests evolve over their careers.