Clinical Sites for the IDeA States Pediatric Clinical Trials Network

IDeA 州儿科临床试验网络的临床站点

• 批准号: 9461960
• 负责人: Rosalyn Singleton
• 金额: $ 129.87万
• 依托单位: ALASKA NATIVE TRIBAL HEALTH CONSORTIUM
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-23 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9461960
• 关键词: Clinical; Sites; IDeA; States; Pediatric

Program Director/Principal Investigator (Last, First, Middle): Singleton, Rosalyn Abstract Alaska Native children experience the some of the highest reported U.S. rates for invasive bacterial disease, pneumonia/bronchiolitis, chronic suppurative lung disease including bronchiectasis, vitamin D deficiency and rickets, and early childhood caries, and high prevalence of obesity and neurodevelopmental disorders. Many of these conditions are associated with environmental influences, including household crowding, lack of piped water, transitioning diet, decreased physical activity, and tobacco exposure. The Alaska Native Tribal Health Consortium (ANTHC), a not-for-profit health organization providing statewide services for Alaska Native people and owned and operated by the Alaska Native people, is collaborating on multiple projects focused on these child health issues. However, development of NIH supported pediatric clinical trials has been challenged by a relatively small population, of which approximately half is widely dispersed in remote areas throughout the state and limited pediatric research infrastructure. ANTHC proposes to become a pediatric clinical trials center within the IDeA States Pediatric Clinical Trials Network to develop the capacity and capability to conduct pediatric clinical trials, particularly in rural and underserved areas of Alaska. ANTHC and its local regional Tribal partner, Southcentral Foundation (SCF), will implement and initiate clinical trials that address Alaska Native child health inequities with priorities on environmental influences on upper/lower airway disease; obesity; pre-, peri-, and postnatal outcomes; and neurodevelopment. ANTHC and SCF clinical and research staff will receive mentoring and professional development through activities within the IDeA program to develop and maintain research capacity thereby improving the ability for these organizations to successfully compete for NIH research funding in the future. ANTHC and SCF researchers will collaborate with other funded investigators to provide greater diversity in pediatric clinical study participation, accelerate study completion, and allow partnering with experienced investigators. ANTHC's participation in this network addresses critical barriers to progress in competing for research funding to address Alaska Native child health inequities through clinical trials. The IDeA pediatric clinical trials network provides an opportunity for ANTHC to participate in evaluations of key interventions with a larger group in a shorter time period and build research capacity to be able to initiate clinical trials. OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) Page Continuation Format Page

项目总监/首席研究员（最后、第一、中间）：Singleton、Rosalyn 抽象的 阿拉斯加原住民儿童的侵袭性细菌性疾病发病率是美国最高的， 肺炎/细支气管炎、慢性化脓性肺病（包括支气管扩张）、维生素 D 缺乏症和 佝偻病和儿童早期龋齿，以及肥胖和神经发育障碍的高患病率。许多 这些情况与环境影响有关，包括家庭拥挤、缺乏管道 水、改变饮食、减少体力活动和接触烟草。阿拉斯加原住民部落健康 Consortium (ANTHC)，一个为阿拉斯加原住民提供全州服务的非营利性健康组织 人，由阿拉斯加原住民拥有和经营，正在合作开展多个项目，重点关注 这些儿童健康问题。然而，NIH 支持的儿科临床试验的发展受到了挑战 人口相对较少，其中大约一半广泛分散在全国偏远地区 国家和有限的儿科研究基础设施。 ANTHC提议成为儿科临床试验 IDeA 国家儿科临床试验网络中心，旨在发展以下方面的能力： 进行儿科临床试验，特别是在阿拉斯加的农村和服务不足的地区。 ANTHC 及其当地 区域部落合作伙伴 Southcentral 基金会 (SCF) 将实施并启动临床试验，以解决 阿拉斯加原住民儿童健康不平等，优先考虑环境对上/下呼吸道的影响 疾病;肥胖;产前、围产期和产后结果；和神经发育。 ANTHC 和 SCF 临床和 研究人员将通过 IDeA 计划内的活动获得指导和专业发展 发展和维持研究能力，从而提高这些组织成功地开展研究的能力 未来争夺NIH研究经费。 ANTHC 和 SCF 研究人员将与其他研究人员合作 资助研究人员提供儿科临床研究参与的更大多样性，加速研究 完成，并允许与经验丰富的调查人员合作。 ANTHC 参与该网络 解决在争夺研究经费以解决阿拉斯加原住民儿童健康问题方面取得进展的关键障碍 通过临床试验消除不平等。 IDeA 儿科临床试验网络为 ANTHC 将在更短的时间内与更多的群体一起参与关键干预措施的评估，并建立 研究能力能够启动临床试验。 OMB 编号 0925-0001/0002（修订版 08/12 已批准至 8/31/2015） 页面延续格式页面