Impact of Prenatal Vitamin D Supplementation on Prenatal Vitamin D Concentrations and Early Childhood Caries
产前补充维生素 D 对产前维生素 D 浓度和儿童早期龋齿的影响
基本信息
- 批准号:10226059
- 负责人:
- 金额:$ 13.94万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-09-06 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:25-hydroxyvitamin DAge-MonthsAlaskaAlaska NativeAmerican College of Obstetricians and GynecologistsBlood specimenCalciumChildCohort StudiesDataDecayed, Missing, and Filled TeethDecision MakingDentalDental CareDental Enamel HypoplasiaDental RecordsDental cariesDevelopmentDietEffectivenessElectronic Health RecordEnsureFluoride VarnishesGeneral AnesthesiaGestational AgeGuidelinesHospitalsInfantLeadMaternal AgeMeasuresMonitorMothersMouth RehabilitationNative American Research Center for HealthOral healthOutcomePharmacy facilityPoliciesPopulationPregnancyPregnant WomenPrenatal carePublishingReportingRicketsRunningSamplingSmokingSupplementationTestingThird Pregnancy TrimesterTimeUmbilical Cord BloodVisitVitamin DVitamin D DeficiencyVitamin D supplementationVitaminsWaterWater fluoridationWomanYukon-Kuskokwim Deltaantenatal carebasecohortdisabilityearly childhoodeffectiveness evaluationevidence baseexperiencefallshigh risk populationimprovedmaternal cigarette smokingparitypregnantprenatalprescription documentpreventrandomized trialrestoration
项目摘要
The Impact of Prenatal Vitamin D Supplementation on Prenatal Vitamin D concentrations and
Early Childhood Caries.
Abstract
Alaska Native (AN) children experience high rates of early rickets and vitamin D deficiency compared with
other US populations. Pregnant AN women from Alaska`s Yukon Kuskokwim (YK) Delta have increased
rates of vitamin D deficiency associated with transition from a traditional marine diet. Alaska Native
children from the YK Delta experience one of the highest reported rates of early childhood caries (ECC). A
Canadian study showed an association between low 25-hydroxyvitamin D (25(OH)D) levels in prenatal
women and ECC in their infants. We evaluated the association between YK Delta prenatal 25(OH)D
levels and ECC in their children using data from the "Maternal Organics Monitoring (MOM) Study”, and
children's electronic dental records to assess ECC by decayed missing and filled teeth (dmft) scores. In
the analysis, children 24-35 months of age with cord blood 25(OH)D <12 ng/ml had a mean dmft score 2.4
times higher than non-deficient” children (p=0.003). There is limited information on the impact of prenatal
supplementation improving vitamin D concentrations in pregnant women and no information on the impact
on ECC. With available evidence, it is unclear whether vitamin D supplementation should be prescribed as
part of routine antenatal care. Therefore, the current American College of Obstetricians and Gynecologists
recommends only the 400 IU of vitamin D in prenatal vitamins. Data in YK Delta women from the MOM
study (2000-2010) showed 91% of 25(OH)D cord blood levels were <20ng/ml (insufficient), and 53% were
<12ng/ml (deficient). In Fall 2015, YK Delta Regional Hospital (YKDRH) evaluated 25(OH)D in prenatal
women – 60% were insufficient (<20ng/ml). In Fall 2016 YKDRH implemented guidelines to add 1000 IU
of daily vitamin D to routinely recommended prenatal vitamins (400 IU) and calcium (200 IU). The recent
Vitamin D supplementation guidelines in YK Delta offers an opportunity to evaluate the impact of prenatal
supplementation on 25(OH)D concentrations and ECC. We propose a cohort study using the electronic
health records and dental records to evaluate: 1) the effectiveness of prenatal vitamin D supplementation
in increasing 25(OH)D concentrations to sufficient levels, 2) the association between deficient prenatal
(25(OH)D concentrations and ECC, and 3) the impact of prenatal vitamin D supplementation on ECC. We
will test the difference in 25(OH)D levels at first prenatal visit and third trimester in women before and after
enhanced vitamin D supplementation, and measure factors associated with compliance. We will evaluate
mean dmft scores between non-deficient and deficient Vitamin D groups, and before and after
supplementation. and explore the relationship of covariates. This Information will help clinicians make
decisions about prenatal vitamin D supplementation in YK Delta and other high risk populations.
产前补充维生素D对产前维生素D浓度的影响
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Rosalyn Singleton其他文献
Rosalyn Singleton的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Rosalyn Singleton', 18)}}的其他基金
Clinical Sites for the IDeA States Pediatric Clinical Trials Network
IDeA 州儿科临床试验网络的临床站点
- 批准号:
9262514 - 财政年份:2016
- 资助金额:
$ 13.94万 - 项目类别:
Clinical Sites for the IDeA States Pediatric Clinical Trials Network
IDeA 州儿科临床试验网络的临床站点
- 批准号:
9461960 - 财政年份:2016
- 资助金额:
$ 13.94万 - 项目类别: