Clinical Sites for the IDeA States Pediatric Clinical Trials Network
IDeA 州儿科临床试验网络的临床站点
基本信息
- 批准号:9262514
- 负责人:
- 金额:$ 1.91万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-21 至 2016-09-22
- 项目状态:已结题
- 来源:
- 关键词:AddressAdherenceAirAlaskaAlaska NativeAreaBacterial InfectionsBronchiectasisBronchiolitisChildChild health careChildhoodChronicChronic lung diseaseClinical ResearchClinical TrialsClinical Trials NetworkCollaborationsCommunitiesCrowdingDataDentalDental cariesDevelopmentDietDiseaseEducationEvaluationFetal Alcohol SyndromeFoodFoundationsFundingFutureHealthHealth PrioritiesHealth StatusHealth systemHepatitisHepatitis AHepatitis B VaccinesHigh PrevalenceHome environmentHospitalizationHouseholdImmunityIncidenceIndigenousInfectionInstructionInterventionIntervention StudiesLifeLower Respiratory Tract InfectionLungLung diseasesMentorsNative-BornNeurodevelopmental DisorderObesityOutcomePediatric ResearchPerinatalPersonsPhysical activityPneumococcal InfectionsPneumoniaPopulationPrevalencePrincipal InvestigatorProviderReportingResearchResearch InfrastructureResearch PersonnelResearch SupportRespiratory syncytial virusRicketsRuralRural CommunityScientistServicesTimeTobacco useTranslational ResearchUnited States National Institutes of HealthVitamin D DeficiencyWaterabstractingbaseclinical research siteearly childhoodexperiencefetal tobacco exposurehealth care service organizationhealth disparityhealth organizationhookahimprovedmemberneurodevelopmentperinatal outcomespostnatalprogramsprospectivequality assurancestudy populationsystems researchtertiary caretobacco exposuretribal healthunderserved rural area
项目摘要
Program Director/Principal Investigator (Last, First, Middle): Singleton, Rosalyn
Abstract
Alaska Native children experience the some of the highest reported U.S. rates for invasive bacterial disease,
pneumonia/bronchiolitis, chronic suppurative lung disease including bronchiectasis, vitamin D deficiency and
rickets, and early childhood caries, and high prevalence of obesity and neurodevelopmental disorders. Many of
these conditions are associated with environmental influences, including household crowding, lack of piped
water, transitioning diet, decreased physical activity, and tobacco exposure. The Alaska Native Tribal Health
Consortium (ANTHC), a not-for-profit health organization providing statewide services for Alaska Native
people and owned and operated by the Alaska Native people, is collaborating on multiple projects focused on
these child health issues. However, development of NIH supported pediatric clinical trials has been challenged
by a relatively small population, of which approximately half is widely dispersed in remote areas throughout
the state and limited pediatric research infrastructure. ANTHC proposes to become a pediatric clinical trials
center within the IDeA States Pediatric Clinical Trials Network to develop the capacity and capability to
conduct pediatric clinical trials, particularly in rural and underserved areas of Alaska. ANTHC and its local
regional Tribal partner, Southcentral Foundation (SCF), will implement and initiate clinical trials that address
Alaska Native child health inequities with priorities on environmental influences on upper/lower airway
disease; obesity; pre-, peri-, and postnatal outcomes; and neurodevelopment. ANTHC and SCF clinical and
research staff will receive mentoring and professional development through activities within the IDeA program
to develop and maintain research capacity thereby improving the ability for these organizations to successfully
compete for NIH research funding in the future. ANTHC and SCF researchers will collaborate with other
funded investigators to provide greater diversity in pediatric clinical study participation, accelerate study
completion, and allow partnering with experienced investigators. ANTHC's participation in this network
addresses critical barriers to progress in competing for research funding to address Alaska Native child health
inequities through clinical trials. The IDeA pediatric clinical trials network provides an opportunity for
ANTHC to participate in evaluations of key interventions with a larger group in a shorter time period and build
research capacity to be able to initiate clinical trials.
OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) Page Continuation Format Page
项目主任/首席调查员(最后、第一、中间):Rosalyn的Singleton
摘要
阿拉斯加土生土长的儿童患侵袭性细菌疾病的比率在美国是最高的,
肺炎/毛细支气管炎,慢性化脓性肺部疾病,包括支气管扩张,维生素D缺乏和
软骨病、儿童早期龋齿以及肥胖症和神经发育障碍的高患病率。许多.
这些情况与环境影响有关,包括家庭拥挤、缺乏管道
水、过渡饮食、减少体力活动和烟草暴露。阿拉斯加原住民部落健康
联盟(ANTHC),一个为阿拉斯加原住民提供全州服务的非营利性健康组织
由阿拉斯加土著人民拥有和运营的人,正在合作多个项目,重点是
这些儿童健康问题。然而,NIH支持的儿科临床试验的发展受到了挑战
人口相对较少,其中约一半广泛分布在各地的偏远地区
国家和有限的儿科研究基础设施。ANTHC建议成为儿科临床试验
IDEA国家儿科临床试验网络中心发展能力和能力
进行儿科临床试验,特别是在阿拉斯加的农村和服务不足的地区。ANTHC及其地方
区域部落合作伙伴,南方基金会(SCF)将实施和启动临床试验,以解决
阿拉斯加原住民儿童健康不平等及其对上/下呼吸道环境影响的优先事项
疾病;肥胖;产前、围产期和产后结局;以及神经发育。ANTHC和SCF的临床和
研究人员将通过IDEA计划内的活动获得指导和专业发展
发展和保持研究能力,从而提高这些组织成功的能力
在未来竞争NIH的研究资金。ANTHC和SCF的研究人员将与其他
资助研究人员在儿科临床研究参与方面提供更大的多样性,加快研究
完成,并允许与经验丰富的调查人员合作。ANTHC参与这一网络
解决在竞争研究资金以解决阿拉斯加土著儿童健康问题方面取得进展的关键障碍
通过临床试验的不平等。IDEA儿科临床试验网络为
ANTHC在更短的时间内与更大的群体一起参与关键干预措施的评估,并建立
具备启动临床试验的研究能力。
OMB编号0925-0001/0002(08/12版批准至2015年8月31日)页面续格式页面
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Rosalyn Singleton其他文献
Rosalyn Singleton的其他文献
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{{ truncateString('Rosalyn Singleton', 18)}}的其他基金
Impact of Prenatal Vitamin D Supplementation on Prenatal Vitamin D Concentrations and Early Childhood Caries
产前补充维生素 D 对产前维生素 D 浓度和儿童早期龋齿的影响
- 批准号:
10226059 - 财政年份:2018
- 资助金额:
$ 1.91万 - 项目类别:
Clinical Sites for the IDeA States Pediatric Clinical Trials Network
IDeA 州儿科临床试验网络的临床站点
- 批准号:
9461960 - 财政年份:2016
- 资助金额:
$ 1.91万 - 项目类别:
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