Biomedical Informatics Core

生物医学信息学核心

• 批准号: 8948615
• 负责人: INDRA N SARKAR
• 金额: $ 51.89万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8948615
• 关键词: Address; Adherence; Adopted; Adoption; Agreement; Basic Science; Big Data; Bioinformatics; Clinical; Clinical Informatics; Clinical Research; Clinical Sciences; Collaborations; Communication; Communication Tools; Computerized Medical Record; Data; Data Security; Data Set; Databases; Development; Discipline; Educational workshop; Effectiveness; Electronics; Elements; Ensure; Environment; Epidemiologic Studies; Epidemiology; Evaluation; Fertilization; Fostering; Goals; Health; High Performance Computing; Hospitals; Informatics; Information Dissemination; Institution; Institutional Policy; Instruction; Leadership; Learning; Mining; Monitor; Online Systems; Output; Participant; Patients; Population; Positioning Attribute; Privacy; Procedures; Regulation; Research; Research Infrastructure; Research Personnel; Research Support; Resource Sharing; Resources; Retrieval; Rhode Island; Secure; Surveys; Training; Translational Research; Vision; abstracting; analytical tool; base; biomedical informatics; cohort; computerized; computerized tools; cyber infrastructure; data sharing; design; health disparity; health record; indexing; inter-institutional; multidisciplinary; operation; population based; programs; support network; tool

ABSTRACT – BIOMEDICAL INFORMATICS AND CYBERINFRASTRUCTURE ENHANCEMENT The key elements of a successful program in clinical and translational research include web-based communication and coordination, research data accumulation and management, secure and privacy-sensitive storage with indexed retrieval, robust computational and analytical tools, expert bioinformatics and computational consultants and collaborators, access to statewide electronic medical and health records, along with rapid and effective dissemination of information. These form the basis of our vision for a proposed Center for Biomedical Informatics that would be critical for the effective operation of the proposed Rhode Island Center for Clinical and Translational Sciences (RI-CCTS). The proposed Center for Biomedical Informatics will provide leadership, organization and integration of biomedical informatics expertise within the participating institutions and create critically important structural and functional biomedical informatic linkages between clinical and basic science investigators. The Center will provide instruction on the implementation and application of new contemporary resources and tools for carrying out population based epidemiological studies, generating clinical surveys and mining new patient databases. It will support research strategies that require the use of “big data” approaches to integrate output from new “omics” platforms with the distinctive patient cohorts in our affiliated hospital network. Our goal is to enable the broad application of high performance computing and cyberinfrastructure in the most effective utilization of our unique population based resources with the aim of benefitting our local population and addressing issues of health disparity in Rhode Island and other IDeA jurisdictions. This multi-institutional Center will create and support professional development opportunities for investigators from wide-ranging disciplines to learn about biomedical informatics. It will facilitate investigators learning about and establishing collaborations with colleagues at their own or different institutions, allowing them to explore new and more powerful computational approaches to clinical and translational research. The Center for Biomedical Informatics will also enable broad access to the large clinical and translational research networks supported through the IDeA-CTR consortium. Lastly, the Center will harness contemporary, computerized resources to track and evaluate the use of limited valuable resources across the RI-CCTS network. To achieve these goals, the Specific Aims are: 1) Create a sustainable, team-based, multidisciplinary Center for Biomedical Informatics to provide the cyberinfrastructure needed to enable effective collaborative clinical and translational research while leveraging all available existing electronic resources. 2) Promote and advance professional development in biomedical informatics through workshops and other activities that will also serve to enhance collaborative interactions within Rhode Island and across the IDeA network. 3) Use contemporary, web-based tools to track and evaluate the use of resources across the RI-CCTS network.

摘要--生物医学信息学与网络基础设施建设 临床和转化性研究项目成功的关键要素包括基于网络的 沟通和协调、研究数据积累和管理、安全和隐私敏感 使用索引检索、强大的计算和分析工具、专家生物信息学和 计算顾问和合作者，访问全州范围的电子医疗和健康记录，以及 迅速有效地传播信息。这些构成了我们对拟建中心的愿景的基础 对于生物医学信息学，这将是拟议的罗德岛中心有效运作的关键 临床与翻译科学(RI-CCTS)。拟建的生物医学信息学中心将提供 在参与机构内领导、组织和整合生物医学信息学专业知识 并在临床和生物医学之间建立极其重要的结构和功能生物医学信息联系 基础科学研究人员。该中心将提供关于执行和应用新的 开展以人口为基础的流行病学研究的当代资源和工具 临床调查和挖掘新的患者数据库。它将支持需要使用 “大数据”方法将来自新的“组学”平台的成果与我们的 附属医院网络。我们的目标是使高性能计算和 最有效地利用我们独特的基于人口的资源的网络基础设施，目的是 造福我们的当地人口和解决罗德岛的健康差距问题等想法 司法管辖区。这个多机构中心将为以下人员创造和支持专业发展机会 来自多个学科的研究人员了解生物医学信息学。这将为调查人员提供便利 了解自己或不同机构的同事并与其建立合作关系，从而 为临床和转化性研究探索新的、更强大的计算方法。这个 生物医学信息学中心还将使人们能够广泛访问大型临床和转化性研究 通过IDEA-CTR联盟支持的网络。最后，该中心将利用当代， 计算机化的资源，以跟踪和评估国际扶轮--共同国家协调制度中有限的宝贵资源的使用情况 网络。为了实现这些目标，具体目标是：1)创建一个可持续的、以团队为基础的、多学科的 生物医学信息学中心提供实现有效协作所需的网络基础设施 临床和转化性研究，同时利用所有现有的电子资源。2)推广和 通过研讨会和其他活动促进生物医学信息学的专业发展 还有助于加强罗德岛内部和整个IDEA网络的协作互动。3)使用 当代的、基于网络的工具，用于跟踪和评估国际扶轮-CCTS网络中的资源使用情况。