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Functions of G-proteins in Endothelial Cells

Functions of G-proteins in Endothelial Cells
内皮细胞中 G 蛋白的功能
批准号：
9176372
负责人：
Xin-Yun Huang
金额：
$42.38万
依托单位：
WEILL MEDICAL COLL OF CORNELL UNIV
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
项目状态：
已结题
起止时间：
2016-06-01 至 2020-04-30
来源：
https://reporter.nih.gov/project-details/9176372
关键词：
ActinsAdultBindingBiochemicalBiological AssayBiological ProcessBlood VesselsC-terminalCapillary Endothelial CellCardiovascular DiseasesCause of DeathCell ProliferationCell membraneCell physiologyCellsCessation of lifeCrystallographyCytoskeletal ModelingDH DomainDefectDevelopmentEmbryoEndothelial CellsFibroblastsG-Protein-Coupled ReceptorsGTP-Binding ProteinsGenetic studyGrowthGuanine Nucleotide Exchange FactorsGuanine NucleotidesHealthHumanIn VitroKnockout MiceLipidsMalignant NeoplasmsMembraneMethodsModificationMolecularMusNucleotidesOvarianPhosphotransferasesPhysiologic NeovascularizationPhysiologicalPlayProteinsRecruitment ActivityRegulationResearchRetinalRoentgen RaysRoleSignal PathwaySignal TransductionSonStem cellsStudy SectionTestingTubeTumor AngiogenesisVascularizationYolk Sacangiogenesisbaseblood vessel developmentcell typecombatgenetic regulatory proteinhuman diseasemigrationnovelorgan regenerationpostnatalpublic health relevance

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Project Description The main focus of this application is on the functions of G-proteins in endothelial cells. G-protein Gα13 is critical for blood vessel formation. This proposal builds on our discovery of a novel mechanism by which Gα13 functions through SOS, a direct regulator of Ras and the new observation that endothelial cell-specific deletion of Gα13 impairs organ regeneration. The first aim is to dissect the biochemical mechanism by which Gα13 regulates SOS in vitro. The second aim is to determine how Gα13 and G-protein- coupled receptors regulate SOS in cells. The third aim is to investigate the impact of endothelial cell-specific deletion of SOS1 on organ regeneration.
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