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Functions of G-proteins in Endothelial Cells

Functions of G-proteins in Endothelial Cells
内皮细胞中 G 蛋白的功能
批准号：
9282797
负责人：
Xin-Yun Huang
金额：
$42.38万
依托单位：
WEILL MEDICAL COLL OF CORNELL UNIV
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
项目状态：
已结题
起止时间：
2016-06-01 至 2020-04-30
来源：
https://reporter.nih.gov/project-details/9282797
关键词：
ActinsAdultBindingBiochemicalBiological AssayBiological ProcessBiophysicsBlood VesselsC-terminalCapillary Endothelial CellCardiovascular DiseasesCause of DeathCell ProliferationCell membraneCell physiologyCellsCessation of lifeCrystallographyCytoskeletal ModelingDH DomainDefectDevelopmentEmbryoEndothelial CellsFibroblastsG-Protein-Coupled ReceptorsG-substrateGTP-Binding ProteinsGenetic studyGrowth FactorGuanine NucleotidesHealthHumanImpairmentIn VitroKnockout MiceLipidsMalignant NeoplasmsMembraneMethodsModificationMolecularMusNucleotidesOvarianPathologicPhosphotransferasesPhysiologicalPlayProteinsRecruitment ActivityRegulationResearchRetinalRoentgen RaysRoleSignal PathwaySignal TransductionSonSon of Sevenless ProteinsStem cellsStudy SectionTestingTubeTumor AngiogenesisVascularizationYolk Sacangiogenesisbaseblood vessel developmentcell typecombatgenetic regulatory proteinhuman diseasemigrationnovelorgan regenerationpostnatalpublic health relevanceras Guanine Nucleotide Exchange Factors

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中文摘要
翻译
项目描述 本申请的主要焦点是G蛋白在内皮细胞中的功能。 G蛋白Gα13对血管形成至关重要。该提案建立在我们的 发现Gα13通过SOS（一种直接调节剂）发挥作用的新机制 和新的观察，即内皮细胞特异性Gα13缺失损害 器官再生第一个目的是剖析生物化学机制， Gα13在体外调节SOS。第二个目的是确定Gα13和G蛋白- 偶联受体调节细胞中的SOS。第三个目标是调查 内皮细胞特异性缺失SOS 1对器官再生的影响。
英文摘要
Project Description The main focus of this application is on the functions of G-proteins in endothelial cells. G-protein Gα13 is critical for blood vessel formation. This proposal builds on our discovery of a novel mechanism by which Gα13 functions through SOS, a direct regulator of Ras and the new observation that endothelial cell-specific deletion of Gα13 impairs organ regeneration. The first aim is to dissect the biochemical mechanism by which Gα13 regulates SOS in vitro. The second aim is to determine how Gα13 and G-protein- coupled receptors regulate SOS in cells. The third aim is to investigate the impact of endothelial cell-specific deletion of SOS1 on organ regeneration.
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