Purchase of Laminar Flow Workstations and Biosafety Cabinets to Protect Personnel and Animals

购买层流工作站和生物安全柜以保护人员和动物

• 批准号: 9119453
• 负责人: Debra L Hickman
• 金额: $ 32.51万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-15 至 2017-03-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9119453
• 关键词: Allergens; Animal Housing; Animal Model; Animals; Applications Grants; Biological; Biomedical Research; Diabetes Mellitus; Ensure; Evaluation; Exposure to; Funding; Health; Housing; Human Resources; Indiana; Institution; Laboratory Animals; Malignant Neoplasms; Population; Rattus; Research; Resources; Rodent; Safety; Schools; Scientist; Universities; animal facility; animal resource; base; improved; medical schools; prevent

 DESCRIPTION (provided by applicant): As is consistent with the majority of institutions performing biomedical research, rodents are the most commonly used species of animal housed at the Indiana University School of Medicine (IUSM) Laboratory Animal Resource Center (LARC). These animals are critical for the School's major research focuses, including studies of cancer, diabetes, and other health problems of importance in the USA. To ensure adequate bioprotection and prevent personnel exposure to allergens, these rodents are generally housed in individually ventilated caging and handled in laminar flow animal transfer stations. Recent internal and external evaluations have determined that we need to upgrade and expand the number of laminar flow animal transfer stations and biological safety cabinets in use in the animal facilities to improve protection of personnel and animals. Specifically, we (1) identified a subset of existing laminar flow animal transfer stations that are not providing appropriate personnel protection; (2) identified an increase in the demand for housing rodents in ABSL2 housing; and (3) determined that we should transition our the majority of our rat colonies from conventional housing to individually ventilated caging. Additionally, we have identified animal rooms where the provision of multiple laminar flow animal transfer stations will enhance compliance with the use of proper protection of animals and personnel. Based on the findings from this evaluation of our resources, funds from this grant proposal will be used to purchase 29 animal transfer change stations and 8 biological safety cabinets. This purchase will allow us to replace the 26 inappropriate hoods, add capacity for the support of BSL2 level animal models, improve the bioprotection for our rat colonies, and allow the placement of multiple animal change stations rooms with large populations of animals and scientists to ensure proper protection of the rodents and personnel.