Regulation of Gammaherpesviral Late Gene Expression
γ疱疹病毒晚期基因表达的调控
基本信息
- 批准号:9049040
- 负责人:
- 金额:$ 37.23万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-11-13 至 2020-10-31
- 项目状态:已结题
- 来源:
- 关键词:Acquired Immunodeficiency SyndromeAffinityAntiviral AgentsArchitectureBindingBiologyCancer EtiologyCellsCodeComplexCongenital DisordersCryoelectron MicroscopyDNADNA VirusesDNA biosynthesisDataDiseaseDouble Stranded DNA VirusElectron MicroscopyEukaryotaEukaryotic CellGene ExpressionGenesGenetic TranscriptionGrantHerpesviridaeHerpesviridae InfectionsHomologous GeneHumanHuman Herpesvirus 8HybridsImageryImmunocompromised HostIndividualInfectionLate Gene TranscriptionsLate PromotersLifeLife Cycle StagesLightLinkMalignant NeoplasmsModelingMolecular MimicryNegative StainingPatientsPolymerasePopulationProcessProteinsRNA Polymerase IIRecruitment ActivityRegulationReportingRoleTATA-Box Binding ProteinTimeTranscription CoactivatorTranscriptional RegulationViralViral GenesViral GenomeViral ProteinsVirionVirusVirus AssemblyVisualbasedefined contributiongammaherpesvirushigh throughput screeningmammalian genomemembermimicrymutantnovelnovel virusparticlepathogenpromoterprotein protein interactionpublic health relevanceresearch studytranscription factor
项目摘要
DESCRIPTION (provided by applicant): Herpesviruses are endemic within the human population, and cause a wide range of life-threatening diseases. Members of the beta-herpesvirus (β-HV) and gamma-herpesvirus (γ-HV) subfamilies are extremely problematic in immunocompromised individuals, leading to severe congenital disorders and a variety of cancers. During the herpesviral replication cycle, viral genes are expressed temporally in an ordered cascade, with timing linked to appropriate life cycle stage needs. Following viral genome replication, a group of viral genes termed late genes (L) are robustly activated and produce proteins necessary for progeny virion assembly and egress. Mechanisms governing L gene expression in the β-HV and the γ-HV largely remain a mystery. However, shedding light on this aspect of herpesviral biology has become a high priority, in part due to recent discoveries demonstrating that mutants impaired in this final viral transcription cascade cannot produce progeny virions. An understanding of the regulatory features critical for L gene transcription may therefore reveal robust new targets for antiviral strategies. Our data demonstrate that late gene transcriptional regulation is unique, as it incorporates both molecular mimicry and selective recruitment of key host transcriptional machinery in a manner not previously observed in viral or host gene expression. Thus, the focus of this grant is to define the composition and regulation of this novel gene expression complex, as well as reveal how it may globally impact gene expression in infected cells.
描述(由申请方提供):疱疹病毒在人群中流行,并引起广泛的危及生命的疾病。β-疱疹病毒(β-HV)和γ-疱疹病毒(γ-HV)亚家族的成员在免疫功能低下的个体中是非常有问题的,导致严重的先天性疾病和各种癌症。在疱疹病毒复制周期中,病毒基因以有序级联的方式在时间上表达,时间与适当的生命周期阶段需求相关。病毒基因组复制后,一组称为晚期基因(L)的病毒基因被强烈激活,并产生子代病毒体组装和外出所必需的蛋白质。β-HV和γ-HV中L基因表达的控制机制在很大程度上仍然是个谜。然而,揭示疱疹病毒生物学的这一方面已经成为一个高度优先事项,部分原因是最近的发现表明,在这个最终的病毒转录级联受损的突变体不能产生后代病毒粒子。因此,了解L基因转录的关键调控特征可能会揭示抗病毒策略的新靶点。我们的数据表明,晚期基因转录调控是独特的,因为它结合了分子模拟和选择性招募的关键宿主转录机制的方式没有以前观察到的病毒或宿主基因表达。因此,这项资助的重点是定义这种新型基因表达复合物的组成和调控,以及揭示它如何在感染细胞中全面影响基因表达。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Britt A Glaunsinger其他文献
Britt A Glaunsinger的其他文献
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{{ truncateString('Britt A Glaunsinger', 18)}}的其他基金
2023 Viruses and Cells Gordon Research Conference and Gordon Research Seminar
2023病毒与细胞戈登研究大会暨戈登研究研讨会
- 批准号:
10609208 - 财政年份:2023
- 资助金额:
$ 37.23万 - 项目类别:
Functional Characterization of Herpesvirus-Activated Noncoding Retrotransposon RNAs
疱疹病毒激活的非编码反转录转座子 RNA 的功能表征
- 批准号:
9975697 - 财政年份:2019
- 资助金额:
$ 37.23万 - 项目类别:
Regulation of Gammaherpesviral Late Gene Expression
γ疱疹病毒晚期基因表达的调控
- 批准号:
10368981 - 财政年份:2015
- 资助金额:
$ 37.23万 - 项目类别:
Regulation of Gammaherpesviral Late Gene Expression
γ疱疹病毒晚期基因表达的调控
- 批准号:
9178643 - 财政年份:2015
- 资助金额:
$ 37.23万 - 项目类别:
Regulation of Gammaherpesviral Late Gene Expression
γ疱疹病毒晚期基因表达的调控
- 批准号:
10223851 - 财政年份:2015
- 资助金额:
$ 37.23万 - 项目类别:
Disruption of Cellular RNA Processing by Kaposi's Sarcoma-Associated Herpesvirus
卡波西肉瘤相关疱疹病毒对细胞 RNA 加工的破坏
- 批准号:
9317435 - 财政年份:2015
- 资助金额:
$ 37.23万 - 项目类别:
Regulation of Gammaherpesviral Late Gene Expression
γ疱疹病毒晚期基因表达的调控
- 批准号:
10576837 - 财政年份:2015
- 资助金额:
$ 37.23万 - 项目类别:
Escape from gammaherpesvirus-induced mRNA destruction
逃避伽马疱疹病毒诱导的 mRNA 破坏
- 批准号:
8148069 - 财政年份:2011
- 资助金额:
$ 37.23万 - 项目类别:
Escape from gammaherpesvirus-induced mRNA destruction
逃避伽马疱疹病毒诱导的 mRNA 破坏
- 批准号:
8309954 - 财政年份:2011
- 资助金额:
$ 37.23万 - 项目类别:
Escape from gammaherpesvirus-induced mRNA destruction
逃避伽马疱疹病毒诱导的 mRNA 破坏
- 批准号:
8459030 - 财政年份:2011
- 资助金额:
$ 37.23万 - 项目类别:
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