Regulation of Gammaherpesviral Late Gene Expression
γ疱疹病毒晚期基因表达的调控
基本信息
- 批准号:10223851
- 负责人:
- 金额:$ 38.79万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-11-13 至 2026-02-28
- 项目状态:未结题
- 来源:
- 关键词:Acquired Immunodeficiency SyndromeAntiviral AgentsArchitectureAreaBindingBinding ProteinsBiological AssayBiologyC-terminalCancer EtiologyCellsCentral AfricaComplexCongenital DisordersCytomegalovirusDNA BindingDNA Binding DomainDNA Polymerase IIDNA VirusesDNA biosynthesisDNA replication originDNA-Directed RNA PolymeraseDataDiseaseDistalDouble Stranded DNA VirusEnhancersEukaryotaGene ActivationGene ExpressionGenesGenetic TranscriptionGenomeGrantHIVHerpesviridaeHumanHuman Herpesvirus 4Human Herpesvirus 8HybridsImmunocompromised HostIndividualInfectionLate Gene TranscriptionsLate PromotersLifeLinkLyticMalignant NeoplasmsMeasuresModelingMolecular MimicryMutationN-terminalOncogenicPatientsPopulationProcessProductionProteinsRegulationReplication OriginRoleTATA BoxTATA-Box Binding ProteinTestingTranscription CoactivatorTranscription InitiationTranscriptional RegulationViralViral GenomeViral ProteinsVirionVirusVirus AssemblyVirus Replicationcancer diagnosisexperimental studygammaherpesvirusinsightmembermimicrymouse modelmutation screeningnovelpathogenpromoterrecruitstructural biologytranscription factorviral DNA
项目摘要
ABSTRACT
Herpesviruses are endemic within the human population, and cause a wide range of life-threatening diseases.
Members of the betaherpesvirus and gammaherpesvirus subfamilies are extremely problematic in
immunocompromised individuals, leading to severe congenital disorders and a variety of cancers. This
proposal will define how a critical class of herpesviral genes are expressed late in the lifecycle of Kaposi's
sarcoma-associated herpesvirus (KSHV) through a mechanism that involves a novel transcription complex,
which combines both viral mimicry and co-option of select host machinery. The set of viral proteins required for
late gene activation are broadly conserved among the beta- and gammaherpesviruses, indicating that
information gained herein for KSHV will likely be applicable for Epstein-Barr virus and human cytomegalovirus
as well. The focus of this grant is to define the composition and regulation of this novel gene expression
complex, and reveal how its function is linked to viral genome replication. Given that even subtle mutations in
this late gene transcription complex effectively `kill' the virus, an understanding of its composition and
regulation is anticipated to reveal new targets for antiviral strategies.
摘要
疱疹病毒在人群中是地方性的,并且引起广泛的威胁生命的疾病。
β疱疹病毒和γ疱疹病毒亚家族的成员在感染中存在极大的问题。
免疫功能低下的个体,导致严重的先天性疾病和各种癌症。这
一项提案将定义一类关键的疱疹病毒基因是如何在卡波济氏病的生命周期后期表达的。
肉瘤相关疱疹病毒(KSHV)通过一种涉及新的转录复合物的机制,
其结合了病毒模拟和选择宿主机制的共选择。一组病毒蛋白需要
晚期基因激活在β和γ疱疹病毒中广泛保守,表明
本文获得的KSHV信息可能适用于EB病毒和人巨细胞病毒
也这项资助的重点是确定这种新基因表达的组成和调控
复杂,并揭示其功能如何与病毒基因组复制相关联。即使是微小的突变,
这种晚期基因转录复合物有效地“杀死"病毒,了解其组成,
预期调控将揭示抗病毒策略的新靶点。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Britt A Glaunsinger其他文献
Britt A Glaunsinger的其他文献
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{{ truncateString('Britt A Glaunsinger', 18)}}的其他基金
2023 Viruses and Cells Gordon Research Conference and Gordon Research Seminar
2023病毒与细胞戈登研究大会暨戈登研究研讨会
- 批准号:
10609208 - 财政年份:2023
- 资助金额:
$ 38.79万 - 项目类别:
Functional Characterization of Herpesvirus-Activated Noncoding Retrotransposon RNAs
疱疹病毒激活的非编码反转录转座子 RNA 的功能表征
- 批准号:
9975697 - 财政年份:2019
- 资助金额:
$ 38.79万 - 项目类别:
Regulation of Gammaherpesviral Late Gene Expression
γ疱疹病毒晚期基因表达的调控
- 批准号:
9178643 - 财政年份:2015
- 资助金额:
$ 38.79万 - 项目类别:
Regulation of Gammaherpesviral Late Gene Expression
γ疱疹病毒晚期基因表达的调控
- 批准号:
10368981 - 财政年份:2015
- 资助金额:
$ 38.79万 - 项目类别:
Regulation of Gammaherpesviral Late Gene Expression
γ疱疹病毒晚期基因表达的调控
- 批准号:
9049040 - 财政年份:2015
- 资助金额:
$ 38.79万 - 项目类别:
Disruption of Cellular RNA Processing by Kaposi's Sarcoma-Associated Herpesvirus
卡波西肉瘤相关疱疹病毒对细胞 RNA 加工的破坏
- 批准号:
9317435 - 财政年份:2015
- 资助金额:
$ 38.79万 - 项目类别:
Regulation of Gammaherpesviral Late Gene Expression
γ疱疹病毒晚期基因表达的调控
- 批准号:
10576837 - 财政年份:2015
- 资助金额:
$ 38.79万 - 项目类别:
Escape from gammaherpesvirus-induced mRNA destruction
逃避伽马疱疹病毒诱导的 mRNA 破坏
- 批准号:
8148069 - 财政年份:2011
- 资助金额:
$ 38.79万 - 项目类别:
Escape from gammaherpesvirus-induced mRNA destruction
逃避伽马疱疹病毒诱导的 mRNA 破坏
- 批准号:
8309954 - 财政年份:2011
- 资助金额:
$ 38.79万 - 项目类别:
Escape from gammaherpesvirus-induced mRNA destruction
逃避伽马疱疹病毒诱导的 mRNA 破坏
- 批准号:
8459030 - 财政年份:2011
- 资助金额:
$ 38.79万 - 项目类别:
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