Aging in 1000 healthy young adults: the Dunedin Study

1000 名健康年轻人的衰老：达尼丁研究

• 批准号: 9134648
• 负责人: AVSHALOM CASPI
• 金额: $ 52.94万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9134648
• 关键词: Age; Aging; Archives; Asthma; Basic Science; Behavioral; Biological; Biological Aging; Biological Markers; Birth; Blood; Cardiovascular Diseases; Caring; Cause of Death; Childhood; Cities; Clinical; Cognitive; DNA; Data; Data Collection; Data Set; Dementia; Deterioration; Development; Diagnosis; Disease; Drug Insurance; Economics; Education; Elderly; Epigenetic Process; Face; Fertility Rates; Future; Genetic; Genomics; Goals; Government; Half-Life; Health; Heritability; Human; Individual; Infant; International; Intervention; Knowledge; Leukocytes; Life; Life Cycle Stages; Life Expectancy; Link; Longevity; Longitudinal Studies; Maintenance; Measures; Medical; Methods; Methylation; Modeling; Molecular; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Onset of illness; Paper; Pathogenesis; Personal Attribute; Personality; Persons; Physiological; Plant Roots; Policy Maker; Population; Prevalence; Primary Health Care; Process; Protocols documentation; Psychopathology; Public Health; Readiness; Records; Research; Risk; Risk Factors; Scoring Method; Smoking; Social Welfare; Social Work; Specific qualifier value; Staging; Surveys; System; Testing; Tissues; Translations; Update; Variant; Work; adverse outcome; age related; aging population; base; biobank; body system; clinical practice; cohort; cost; disability; early onset; economic cost; endophenotype; experience; follow-up; genetic profiling; genome wide association study; genomic signature; health care service; health record; improved; member; middle age; multidisciplinary; neglect; peer; prevent; research and development; simulation; social; telomere; theories; tool; young adult

 DESCRIPTION (provided by applicant): Declining fertility rates, aging of the baby-boomers, and increasing life expectancy are leading to population aging. As the population ages, this increases the public-health burden of age-related conditions, such as cardiovascular disease, type 2 diabetes, and dementia. Treating un-prevented diseases in late life has proven costly and ineffective. It is now known that potentially preventable risk exposures and physiological causes of age-related disease emerge in childhood. This recognition lends new scientific significance to studies that have followed cohorts from childhood. It is also now known that the pathogenesis of age-related diseases involves gradually accumulating decline in organ systems, beginning in the first half of the life course. Consequently, new interventions aiming to prevent age-related diseases will have to be applied to individuals while they are yet young, before they reach midlife. Translation of basic-science geronotology discoveries into interventions for young humans is lacking because virtually nothing is known about the process of biological aging during the first half of the life course. This prompts our proposal to study the pace of biological aging from the twenties forward. We will use the Dunedin Multidisciplinary Health & Development Study, a longitudinal study of a birth cohort now entering its fifth decade. This study combines methods of demographic/economic surveys, clinical- quality health assessments, biobanking, and linkage to nationwide administrative records (health, welfare, finances). We propose to administer a full-day data-collection protocol to the 1004 living members of the birth cohort. To assess each cohort member's pace of biological aging we will: (a) measure biomarkers across multiple organ systems, and (b) statistically model correlated change in these biomarkers assessed at ages 26, 32, 38, and 45 years. We will describe individual variation in the pace of aging, plus its developmental origins, genomic signatures, functional consequences, and economic costs. We will identify attributes that set apart individuals whose bodies are months or years younger than their chronological age. The proposed work will improve knowledge by generating findings to support future interventions to slow aging, prevent age-related disease, and improve the quality of longer lives.

 描述（由申请人提供）：生育率下降、婴儿潮一代的老龄化以及预期寿命的延长正在导致人口老龄化。随着人口老龄化，心血管疾病、2 型糖尿病和痴呆等与年龄相关的疾病的公共卫生负担增加。事实证明，治疗晚年未预防的疾病成本高昂且无效。现在已知，潜在的可预防风险暴露和与年龄相关的疾病的生理原因出现在儿童时期。这一认识为从儿童时期开始跟踪研究的研究赋予了新的科学意义。现在还知道，与年龄相关的疾病的发病机制涉及从生命历程的前半段开始逐渐累积的器官系统衰退。因此，旨在预防与年龄相关的疾病的新干预措施必须在个体年轻、中年之前应用。由于对生命历程前半段的生物衰老过程几乎一无所知，因此缺乏将基础科学老年学发现转化为对年轻人的干预措施。这促使我们建议研究生物的步伐 从二十几岁开始衰老。我们将使用达尼丁多学科健康与发展研究，这是一项针对现已进入第五个十年的出生队列的纵向研究。这项研究结合了人口/经济调查、临床质量健康评估、生物样本库以及与全国行政记录（健康、福利、财务）的联系的方法。我们建议对出生队列中 1004 名在世成员实施全天数据收集方案。为了评估每个队列成员的生物衰老速度，我们将：(a) 测量多个器官系统的生物标志物，以及 (b) 在 26、32、38 和 45 岁时评估的这些生物标志物的统计模型相关变化。我们将描述衰老速度的个体差异，以及其发育起源、基因组特征、功能后果和经济成本。我们将找出那些身体比实际年龄年轻几个月或几年的个体的特征。拟议的工作将通过产生支持未来减缓衰老、预防与年龄相关的疾病和提高长寿质量的干预措施的研究结果来增进知识。