Omics of Inflammatory Airway Diseases

描述（由申请人提供）：肺部疾病组学职业发展计划（K12）的目标是开发和评估一个跨学科的项目，该项目将教育年轻的肺部研究者使用综合“组学”技术的方法，包括基因组学、蛋白质组学、代谢组学、生物信息学、计算建模和系统生物学。学者（2人/年，第2年至第5年）将是临床或研究（博士后）导师或最近任命的助理教授，他们在5年内完成住院医师或获得博士学位。学者有望成为独立的研究者，并在使用组学技术阐明肺部疾病方面发挥领导作用。该项目的中心组学重点是利用华盛顿大学教师的坚定承诺，应用多种基于组学的方法来研究炎症性气道疾病的生物学基础。为了确保在临床研究方法方面的专业知识，负责任的研究行为以及提交K奖申请的科学先决条件，学者们将在华盛顿大学临床与转化科学研究所（CTSA: UL1 TR000448-06）赞助的成熟的临床研究培训中心（CRTC）（TL1 TR000449-06和KL2 TR000450-06）学习课程。此外，在第一年，为了获得组学研究经验，学者们将与已建立的组学或肺科研究团队一起参加为期3个月的教育浸入式轮岗，并参加相关的、正在进行的会议、期刊俱乐部和讲座。每位学者的指导研究经历将在第一年的1月开始，届时将选出一个导师团队和奖学金监督委员会，该委员会将在第二年的2月之前为她/他提交K奖申请做准备。该职业发展计划的具体目标包括：具体目标(1)：我们将提供临床研究、组学策略和系统生物学方面的基础培训，重点是转化研究。具体目标(2)：我们将为学者提供广泛的职业发展指导，并制定以肺部疾病为重点的独立研究计划。具体目标(3)：我们将帮助学者准备独立的职业发展研究基金，如K08、K23和R01奖，并充分利用参与导师的非凡资源和机构环境。具体目标(4)：我们将制定并实施计划，在项目完成后的10年内，对每位学者的有效性和成功进行评估和跟踪。

DESCRIPTION (provided by applicant): The objectives of the Career Development Program in Omics of Lung Diseases (K12) entitled "Omics of Inflammatory Airway Diseases" are to develop and evaluate an interdisciplinary program that will educate young pulmonary investigators in methods of integrative "omics" technologies including genomics, proteomics, metabolomics, bioinformatics, computational modeling, and systems biology. Scholars (2/year for years 2 through 5 of this Award) will be clinical or research (postdoctoral) instructors or recently appointed Assistant Professors who are within 5 years of completion of residency or receipt of Ph.D. Scholars are expected to become independent investigators and assume leadership roles in using omics technologies to elucidate pulmonary diseases. The central omics focus of the program exploits the strong commitment of the faculty at Washington University to apply multiple omics-based methods to investigation of the biological basis of inflammatory airway diseases. To insure expertise in clinical research methods, responsible conduct of research, and the scientific prerequisites for submission of a K Award application, the scholars will take courses in the well-established Clinical Research Training Center (CRTC)(TL1 TR000449-06 and KL2 TR000450-06) sponsored by Washington University's Institute of Clinical and Translational Sciences (CTSA: UL1 TR000448-06). Also during the first year, to provide hands on omics research experience, scholars will participate in 3 month, educational immersion rotations with established omics- or pulmonary-based teams of investigators, and attend relevant, ongoing conferences, journal clubs, and lectures. Each scholar's mentored research experience will begin in January of the first year with the selection of a mentor team and scholarship oversight committee that will prepare her/him for submission of a K Award application by February of the second year. The Specific Aims for this career development program will include: Specific Aim (1): We will provide fundamental training in clinical research, omics strategies, and systems biology with emphasis on translational research. Specific Aim (2): We will provide extensive mentoring to the scholars for career development and for developing independent research plans that focus on lung diseases. Specific Aim (3): We will support scholars by helping them prepare independent career development research grants such as K08, K23, and R01 Awards and by taking full advantage of the extraordinary resources of the participating mentors and institutional environment. Specific Aim (4): We will develop and implement plans for evaluating and tracking the effectiveness and success of these efforts for each scholar up to 10 years after completion of the program.