Self-Motile Electrodes for Three Dimensional, Non-perturbative Recording and Stimulation

用于三维、非微扰记录和刺激的自动电极

• 批准号: 9055566
• 负责人: NICHOLAS A MELOSH
• 金额: $ 23.7万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2017-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9055566
• 关键词: Back; Behavior; Brain; Brain region; Cells; Characteristics; Charge; Complement; Complex; Coupled; Development; Device Designs; Devices; Diagnosis; Dimensions; Disease; Electrodes; Elements; Human; Hydrogels; Immune response; Individual; Liquid substance; Location; Measurement; Measures; Mechanics; Metals; Methods; Microfluidics; Motion; Neurons; Neurosciences; Optics; Performance; Process; Property; Pump; Sampling; Side; Signal Transduction; Site; Slice; Speed; Surface; System; Techniques; Testing; Theoretical model; Thick; Tissues; Transistors; base; brain machine interface; clinical application; data management; density; design; flexibility; in vivo; method development; neurophysiology; parylene; phantom model; public health relevance; relating to nervous system; tool

 DESCRIPTION (provided by applicant): Transitioning from small numbers of neural depth recording electrodes to many thousands requires consideration not only of data management, but also how to non-destructively deliver these electrodes into the desired brain regions. Simply developing larger planar probes with more electrodes packed onto the surface invites increased immune response, likelihood of neuronal perturbation due to the presence of the large foreign substrate, and limited spatial sampling distributions. Here we propose to break the paradigm of mechanically stiff shuttles to insert electrodes, but instead will develop arrays of ultra-small 'slf-motile' electrodes that are each able to move to a target region under their own power, and with minimal perturbation of surrounding cells. This process is based upon electro-osmotic drives developed for microfluidics, which propel fluid along the electrode surface. We will investigate the device design and electrical optimization for guiding micron scale, flexible electrodes to specific locations. This will be complemented by organic electrochemical transistors as the recording elements, which are less sensitive to small sizes than metal electrode pads. The combination of minimal cell perturbation, ultra-small dimensions, and arbitrary three dimensional distributions will create a highly functional network of electrodes to record and modulate complex neural behavior throughout the brain. This non-perturbative, high-density sampling platform could have revolutionary impact both for fundamental neuroscience as well as clinical applications, such as brain-machine interfaces.