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The Female Urinary Microbiome: Adjacent Microbiomes and Clinical Associations

女性尿液微生物组：邻近微生物组和临床关联

基本信息

批准号：
9039781
负责人：
ALAN J WOLFE
金额：
$ 29.42万
依托单位：
LOYOLA UNIVERSITY CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-15 至 2017-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9039781
关键词：
Adult Affect Anogenital region Area Bacteria Basic Science Benign Bioinformatics Biological Assay Bladder Caring Catheters Characteristics Clinical Clinical Research Clinical Treatment Collaborations Communities Complement Coupled Culture Techniques DNA Sequence Data Detection Development Diagnosis Disease Education Etiology Female Funding Genetic Genomics Goals Health Immunology Institution Interdisciplinary Study Investigation Knowledge Lead Life Medical Students Microbiology Molecular Molecular and Cellular Biology National Institute of Diabetes and Digestive and Kidney Diseases Occupations Operative Surgical Procedures Organism Outcome Pain Disorder Pelvic floor structure Pelvis Physiology Positioning Attribute Prevention Process Proteomics Reporting Request for Applications Research Research Personnel Research Project Grants Research Training Resources Role Sampling Science Scientist Seminal Solid Specimen Stress Urinary Incontinence Swab Symptoms Testing Time Training Translational Research Urinary Incontinence Urinary tract Urinary tract infection Urine Urologic Diseases Urology Urothelium Vagina Woman Work base career development clinical Diagnosis clinical practice clinically relevant common treatment database design disorder prevention experience graduate student improved innovation insight interest member microbial microbiome novel patient oriented pelvic organ prolapse programs public health relevance repository treatment response urinary urologic

项目摘要

DESCRIPTION (provided by applicant): The Loyola Urinary Education and REsearch Collaborative (LEUREC) is an established multidisciplinary research team consisting of clinicians, molecular biologists, and computational scientists that work closely in the area of urinary health, with special expertise in the female urinary microbiome (FUM) and its interactions with female urothelial function. The major scientific focus of this P20 application is the relationship of the FUM to the adjacent vaginal and perineal microbiomes, associations of these pelvic floor microbiomes with urinary symptoms and clinical outcomes, and initiation of a urologic microbiome database designed to benefit the entire urologic research community. The educational focus is to cross-train undergraduates, medical and graduate students, clinicians, basic scientists, bioinformaticians and biostatisticians in the emerging field of urinary microbiomics. By beginning exploration into the origins of the FUM, and by identifying associations between the different pelvic floor microbiomes and urinary symptoms and clinical outcomes, we expect the proposed study will impact broad areas of urinary research, especially urinary incontinence, but also urinary tract infection and urinary pain disorders. The intent is to advance prevention, clinical diagnosis and treatment.

描述（由申请人提供）：洛约拉泌尿教育和研究协作（LEUREC）是一个由临床医生，分子生物学家和计算科学家组成的多学科研究团队，他们在泌尿健康领域密切合作，在女性泌尿微生物组（FUM）及其与女性尿路上皮功能的相互作用方面具有特殊的专业知识。该P20应用程序的主要科学重点是 FUM与邻近阴道和会阴微生物组的关系，这些盆底微生物组与泌尿系统症状和临床结果的相关性，以及旨在使整个泌尿系统研究社区受益的泌尿系统微生物组数据库的启动。教育重点是交叉培训本科生，医学和研究生，临床医生，基础科学家，生物信息学家和生物统计学家在新兴的泌尿微生物领域。通过开始探索FUM的起源，并通过确定不同盆底微生物组与泌尿系统症状和临床结果之间的关联，我们预计拟议的研究将影响泌尿系统研究的广泛领域，特别是尿失禁，以及尿路感染和尿路疼痛疾病。目的是先进的预防、临床诊断和治疗。