Social Support as a Facilitator of Adherence to HIV Pre-Exposure Prophylaxis Among Young MSM of Color

社会支持促进年轻有色人种男男性行为者遵守艾滋病毒暴露前预防

• 批准号: 9270216
• 负责人: Sarah Marian Wood
• 金额: $ 7.09万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-02 至 2019-03-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9270216
• 关键词: AIDS prevention; AIDS/HIV problem; Address; Adherence; Adolescence; Adolescent; Adult; African American; Anti-Retroviral Agents; Biological Assay; Biometry; Caring; Cohort Studies; Color; Cross-Sectional Studies; Data; Data Analyses; Decision Making; Development; Epidemic; Epidemiology; Evidence based intervention; Exercise; Face; Fellowship; Foundations; Funding Applicant; Future; HIV; HIV Infections; HIV Seropositivity; Health Policy; Hispanics; Incidence; Individual; Infection; Intervention; Interview; K-Series Research Career Programs; Life; Link; Master of Science; Measures; Mentored Patient-Oriented Research Career Development Award; Mentorship; Methods; Modeling; Motivation; National Research Service Awards; Network-based; Participant; Patients; Persons; Pharmaceutical Preparations; Pharmacy facility; Policy Research; Population; Prophylactic treatment; Publications; Qualifying; Qualitative Methods; Qualitative Research; Records; Research; Research Design; Research Methodology; Research Support; Risk; Role; Serum; Social support; Staging; Structure; Supervision; Surveys; Tenofovir; Testing; United States; United States National Institutes of Health; Urine; Wood material; Youth; antiretroviral therapy; base; career development; cohort; design; early adolescence; emtricitabine; experience; high risk; improved; innovation; insight; lifetime risk; medication compliance; men who have sex with men; multidisciplinary; novel; patient oriented; pill; prevent; prophylactic; prospective; response; skills; social networking website; stem; success; therapy development; tool; transgender women; trend; uptake; young men who have sex with men

Project Summary      Over the past decade, HIV infections have increased by 87% among young men who have sex with men  (YMSM) of color. Reversing this trend will require the use of HIV pre-­exposure prophylaxis (PrEP). However,  increasing PrEP access alone will not change the face of the epidemic. As PrEP efficacy is highly correlated  with levels of adherence, and no evidence based interventions yet exist to support PrEP adherence, it will be  crucial to identify factors associated with improved adherence to PrEP in YMSM. Social support has been  described as a facilitator of adherence in qualitative data from PrEP trials. Understanding how social support  operates in the PrEP-­adherence relationship is essential prior to developing potential social support-­based  interventions to optimize PrEP adherence.  However, no studies have yet formally analyzed the potential  association between social support and PrEP adherence among YMSM.     In response to the critical need for research delineating the role of social support in PrEP adherence for  YMSM, we propose the following specific aims:1) to discover themes related to identification and utilization of  HIV pre-­exposure prophylaxis (PrEP)-­related support and social support network structure within social support  networks of YMSM of color receiving PrEP;; and 2) to determine the association between social support and  current and sustained adherence to PrEP among a cohort of YMSM of color. To achieve aim 1, we will conduct  a mixed methods qualitative and network analytic study using in-­depth interviews and sociograms to explore  themes of how participants identify PrEP-­related support figures, how social support is structured, and the  ways in which support figures may facilitate PrEP adherence. For aim 2, we will use a cross-­sectional study  design to test for an association between social support, as measured with a well-­validated multi-­dimensional  survey instrument, and current PrEP adherence using a novel urine assay to detect tenofovir;; and a  longitudinal cohort design to test for an association between social support as measured above and sustained  PrEP adherence using pharmacy refill data. The proposed research is both innovative and relevant to the NIH  HIV/AIDS priority of supporting research to develop methods of PrEP delivery that mitigate adherence issues.     The proposed research will require skills in epidemiology, biostatistics, qualitative research methods, and  network analytics. The Kirschstein-­NRSA Individual Postdoctoral Fellowship will thus be essential to the  success of this research by providing funding for the applicant to complete qualitative methods and  introductory network analytics courses through the Masters of Science in Health Policy Research and provide  a second year of courses in advanced topics in epidemiology and networks under the supervision of a highly  qualified, multidisciplinary mentorship team who will guide the candidate in her career development. The  longer-­term objectives of the applicant are to complete data analysis, disseminate results through  presentations and publication, and use the results as a foundation for a future K award application.

项目总结